Basic skin care in atopic dermatitis – new and established treatment options

Chylla, Ricarda; Schnopp, Christina; Volz, Thomas

doi:10.1111/ddg.13594

Cited by 5 publications

(6 citation statements)

References 34 publications

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“…Considering that barrier dysfunction with epidermal water loss has an important relationship with AD, topical treatment using emollient is usually encouraged as a basic therapy [3,31,32]. Glatz et al in 2018 conducted an experiment in 6-month-old infants with family history of AD [33].…”

Section: Emollient Usementioning

confidence: 99%

A Calm, Dispassionate Look at Skin Microbiota in Atopic Dermatitis: An Integrative Literature Review

Wan

Chen

2020

Dermatol Ther (Heidelb)

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Atopic dermatitis (AD) is a chronic common inflammatory skin disorder with clinical characteristics of pruritic, dry, and recurrent flares that involve the whole body. Recent studies have demonstrated that the skin microbiota, characterized by an overgrowth of Staphylococcus aureus (S. aureus), plays a critical role in the manifestation of AD. There is striking evidence that skin microbiota can modulate the development and progression of AD. Therefore, more and more therapeutic approaches are adopted for modifying skin microbiota. Here we discuss the role of skin microbiota in the etiology and maintenance of AD; furthermore, we summarize the effects of therapeutic treatments on skin microbiota in AD based on published literature. With the help of the theoretical guidance suggested by microbial metagenome analysis, the reconstitution of microbiota should be a promising way to harness the pathogens of AD and could be used as a brandnew therapeutic strategy in clinical trials. We believe that the targeted therapy of dysbiosis in AD may possibly become a unique approach to an integrated treatment program in the near future.

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Section: Emollient Usementioning

confidence: 99%

A Calm, Dispassionate Look at Skin Microbiota in Atopic Dermatitis: An Integrative Literature Review

Wan

Chen

2020

Dermatol Ther (Heidelb)

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“…Several studies investigated the presence of ACD in patients with AD, with controversial results [10,12,13]. Given that recent studies have shown an immunological and barrier-compromising pre-activation of cells and cytokines even in unaffected skin of patients with atopic dermatitis [14,15], we chose a different, more refined approach: Atopic skin diathesis can be thoroughly assessed by the Erlangen Atopy Score (EAS) which was established and validated in the 1990s by Thomas Diepgen and colleagues [16,17]. This at least in Germany well-established and widely used score integrates 24 items to measure and calculate the probability of atopic skin diathesis (Table S1, online Supporting Information).…”

Section: Introductionmentioning

confidence: 99%

Atopic skin diathesis rather than atopic dermatitis is associated with specific contact allergies

Forkel

Cevik

Schill

et al. 2021

J Deutsche Derma Gesell

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Summary Background The association of atopic dermatitis (AD) and allergic contact dermatitis has been a matter of considerable uncertainty. Study results range from lack of any association to increased sensitization for multiple allergens, but fail to identify consistent allergen associations. Objective We studied a large patch test cohort of patients stratified by their atopic skin diathesis using the Erlangen Atopy Score (EAS), independent of active skin disease. Methods Retrospective multi‐center data analysis from five departments of dermatology in Germany with 4,509 patients. Patients were grouped as “no atopic skin diathesis” (n = 2,165) and “atopic skin diathesis” (n = 1,743), according to EAS. Results Significantly more individuals with atopic skin diathesis showed at least one positive patch test reaction to the baseline series compared to individuals without atopic skin diathesis (49.1 % vs. 38.3 %). In logistic regression analyses, atopic skin diathesis was associated with a significantly higher risk of sensitization to methylchloroisothiazolinone/methylisothiazolinone (OR 2.383) and methylisothiazolinone (OR 1.891), thiuram mix (OR 1.614), as well as nickel (OR 1.530), cobalt (OR 1.683), and chromium (OR 2.089). Conclusions Atopic skin diathesis proved to be the most important intrinsic risk factor for contact sensitization to few, specific allergens. Past or present AD was a less relevant variable.

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“…The treatment of AD follows a stepwise approach that is tailored according to disease severity and extension [85,97]. Patient's education and basic skin care must be carried out in all patients, including those without active skin lesions.…”

Section: Atopic Dermatitismentioning

confidence: 99%

Quality of Life in Patients with Skin Disease and Their Cohabitants

Montero‐Vílchez¹,

Sánchez‐Díaz²,

Martínez-López³

et al. 2022

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Health evaluation implies assess multidimensional aspects of a person’s development, such as physical, social, psychological, and emotional features. It is important to consider all these factors to apply a needs-oriented each patient approach. Chronic skin diseases have a great impact on quality of life, even more than other chronic conditions. For example, hidradenitis suppurativa is estimated to impair quality of life more than cardiovascular disease, lung disease or endocrine diseases. Multiple tools have been developed to measure health-related quality of life in patient, being the Dermatology Life Quality Index (DLQI) the most used. Psoriasis, hidradenitis suppurativa, acne, atopic dermatitis and hair disorders are those with the greatest impact on patients’ quality of life. Moreover, chronic skin conditions impair not only patients’ quality of life, but also cohabitants. Nevertheless, there is scarce information regarding the impact on their cohabitants. So, the objective of this chapter is to review the literature to assess the psychological and social effects of dermatological conditions both on patients and cohabitants.

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Basic skin care in atopic dermatitis – new and established treatment options

Cited by 5 publications

References 34 publications

A Calm, Dispassionate Look at Skin Microbiota in Atopic Dermatitis: An Integrative Literature Review

A Calm, Dispassionate Look at Skin Microbiota in Atopic Dermatitis: An Integrative Literature Review

Atopic skin diathesis rather than atopic dermatitis is associated with specific contact allergies

Quality of Life in Patients with Skin Disease and Their Cohabitants

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