Basophil Production

Denburg, Judah A.; Davison, Maureen; Bienenstock, John

doi:10.1172/jci109682

Cited by 28 publications

(3 citation statements)

References 25 publications

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“…[1][2][3][4][5] In common with all other granulomonocytic cells, basophils are replenished constantly throughout life from a pool of multilineage and committed bone marrow (BM) progenitor cells. [5][6][7][8][9] Thus, basophil differentiation and maturation take place in BM cavities. After maturation, basophils typically are circulating cells that have the capacity to transmigrate into tissues and to contribute to inflammatory reactions.…”

Section: In Myeloproliferative Disorders (Mpds) Basophils Typically mentioning

confidence: 99%

Identification of Basogranulin (BB1) as a Novel Immunohistochemical Marker of Basophils in Normal Bone Marrow and Patients With Myeloproliferative Disorders

et al. 2006

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In myeloproliferative disorders (MPDs), basophils typically increase in number in the bone marrow (BM) and blood. In chronic myeloid leukemia (CML), basophilia is a diagnostic and prognostic variable. However, no reliable approach for routine detection and enumeration of basophils in BM sections is available. We applied the antibasogranulin antibody BB1 on paraffin-embedded BM sections in 21 control samples (normal BM), 45 patients with CML, 9 with chronic idiopathic myelofibrosis, 11 with polycythemia vera, 19 with essential thrombocythemia, and 7 with indolent systemic mastocytosis. As assessed by immunostaining of serial BM sections, BB1+ cells coexpressed myeloperoxidase, histidine decarboxylase, and leukosialin but did not express B- or T-cell-restricted antigens. BB1+ BM cells were found to be highly elevated in patients with CML compared with normal BM or other MPDs, with maximum counts found in accelerated phase CML (median, 160 cells/mm(2)). In summary, BB1 (basogranulin) is a new immunohistochemical basophil marker that should allow quantification of basophils in CML at diagnosis and during therapy.

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Section: In Myeloproliferative Disorders (Mpds) Basophils Typically mentioning

confidence: 99%

Identification of Basogranulin (BB1) as a Novel Immunohistochemical Marker of Basophils in Normal Bone Marrow and Patients With Myeloproliferative Disorders

et al. 2006

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“…[1][2][3][4][5] Under physiological conditions, basophils are primarily produced in the bone marrow. [6][7][8][9] After maturation, they typically reside in the circulation until recruited into tissue sites of inflammation. Basophils express a unique composition of cytoplasmic mediators and cell surface membrane antigens.…”

mentioning

confidence: 99%

Enumeration and immunohistochemical characterisation of bone marrow basophils in myeloproliferative disorders using the basophil specific monoclonal antibody 2D7

Agis

Krauth²,

Mosberger³

et al. 2006

J Clin Pathol

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“…In 1980, Denburg et al [20] succeeded in obtaining guinea pig basophils (basophils are a dominant cell type compared to mast cells in guinea pig) in vitro by culturing bone marrow cells in the presence of supernatant derived from antigen-activated lymphocytes. Then, culture of mouse mast cells was reported by several groups almost simultaneously using a similar system: culture of bone marrow or spleen hematopoietic cells in the presence of supernatants derived from antigen-activated lymphocytes [21] .…”

Section: Discovery Of Mast Cell Origin and The Culture Methodsmentioning

confidence: 99%

Mast Cell Research

Saito

2014

History of Allergy

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The role of mast cells in allergy remained unrevealed until the observation that they contained histamine in 1953, and then the discovery of immunoglobulin E (IgE) in 1966, nearly a century after Ehrlich's first publication. After the discovery of IgE, myeloma-derived IgE from Peter Shackford, who made a great contribution to mankind by providing 40 liters of plasma in the year prior to his death, was distributed to many researchers. This accelerated the exploration of the mechanisms involved in allergic reactions, especially regarding the role of mast cells in IgE-mediated reactions. The identification of mast cells as a progeny of a bone marrow hematopoietic stem cell in 1977 led us to the successful in vitro culture of mast cells. Along with the development of molecular biological techniques, the structure of the high-affinity IgE receptor (FcεRI) was determined in 1989. Thus, we now understand the whole molecules the expression of which is changed when mast cells are activated via FcεRI cross-linking. However, the physiological and pathological roles of mast cells, especially where IgE is not involved, are not yet fully understood. It will be necessary to determine the mechanisms involved in the 'non-IgE-mediated' steps of mast cell activation in allergic or other diseases.

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Basophil Production

Cited by 28 publications

References 25 publications

Identification of Basogranulin (BB1) as a Novel Immunohistochemical Marker of Basophils in Normal Bone Marrow and Patients With Myeloproliferative Disorders

Identification of Basogranulin (BB1) as a Novel Immunohistochemical Marker of Basophils in Normal Bone Marrow and Patients With Myeloproliferative Disorders

Enumeration and immunohistochemical characterisation of bone marrow basophils in myeloproliferative disorders using the basophil specific monoclonal antibody 2D7

Mast Cell Research

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