Bat Lyssaviruses, Northern Vietnam

Nguyen, Anh Thi Kieu; Nguyen, Thu Tuyet; Noguchi, Akira; Nguyen, Dong Vinh; Ngo, Giang Chau; Thong, Vu Dinh; Olowokure, Babatunde; Inoue, Satoshi

doi:10.3201/eid2001.130813

Cited by 9 publications

(9 citation statements)

References 6 publications

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“…None of the 164 bat brain samples tested in this study was positive for rabies antigen or viral RNA suggesting the absence of an active rabies infection, comparable to other studies in Asia [19][20][21][22]. Active bat surveillance for RABV and/or other lyssaviruses in several other countries in Europe or Latin America have also reported a very low prevalence of viral antigen or nucleic acid in healthy bat populations [23][24][25][26].…”

Section: Discussionsupporting

confidence: 83%

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Serological Evidence ofLyssavirusInfection among Bats in Nagaland, a North-Eastern State in India

et al. 2017

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Bats are known to be reservoirs of several medically important viruses including lyssaviruses. However, no systematic surveillance for bat rabies has been carried out in India, a canine rabies endemic country with a high burden of human rabies. Surveillance for rabies virus (RABV) infection in bats was therefore carried out in Nagaland, a north-eastern state in India at sites with intense human-bat interfaces during traditional bat harvests. Brain tissues and sera from bats were tested for evidence of infection due to RABV. Brain tissues were subjected to the fluorescent antibody test for detection of viral antigen and real-time reverse transcriptase PCR for presence of viral RNA. Bat sera were tested for the presence of rabies neutralizing antibodies by the rapid fluorescent focus inhibition test. None of the bat brains tested (n = 164) were positive for viral antigen or viral RNA. However, rabies neutralizing antibodies were detected in 4/78 (5·1%) bat sera tested, suggesting prior exposure to RABV or related lyssaviruses. The serological evidence of lyssaviral infection in Indian bats may have important implications in disease transmission and rabies control measures, and warrant extensive bat surveillance to better define the prevalence of lyssaviral infection in bats.

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Section: Discussionsupporting

confidence: 83%

“…In southern China, 15 (2·2%) of 685 bat sera from three bat species were positive for RABV antibodies, predominantly in frugivorous species R. leschenaultii [29]. Ninety (11·4%) of 789 bat sera tested in northern Vietnam in a recent study had neutralizing antibodies against RABV, mainly from insectivorous bats [21].…”

Section: Discussionmentioning

confidence: 99%

Serological Evidence ofLyssavirusInfection among Bats in Nagaland, a North-Eastern State in India

et al. 2017

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“…Our data reveal that on SWIO islands, antibodies to lyssaviruses are present at high rates, both in frugivorous and insectivorous bats as already reported from Asia [ 37 , 38 ]. The rates of seropositivity reported in our study varied from 10.0% to 44.4% in bat species for which the sampling was sufficient (n > 20 individuals).…”

Section: Discussionsupporting

confidence: 71%

“…The high positive rates reported herein have also been found in other studies outside the region of insectivorous bat species, such as 60.8% (n = 45/74) for Taphozous sp. and 50.0% (n = 63/126) for Hipposideros larvatus in northern Vietnam [ 37 ], 59.0% (n = 62/105) for Scotophilus kuhlii and 54.1% for Philetor brachypterus in the Philippines [ 39 ]. Similarly, high rates have been reported in frugivorous bat species, such as 51.9% (n = 14/27) for Pteropus hypomelanus in the Philippines [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Serological Evidence of Lyssaviruses among Bats on Southwestern Indian Ocean Islands

et al. 2016

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We provide serological evidence of lyssavirus circulation among bats on southwestern Indian Ocean (SWIO) islands. A total of 572 bats belonging to 22 species were collected on Anjouan, Mayotte, La Réunion, Mauritius, Mahé and Madagascar and screened by the Rapid Fluorescent Focus Inhibition Test for the presence of neutralising antibodies against the two main rabies related lyssaviruses circulating on the African continent: Duvenhage lyssavirus (DUVV) and Lagos bat lyssavirus (LBV), representing phylogroups I and II, respectively. A total of 97 and 42 sera were able to neutralise DUVV and LBV, respectively. No serum neutralised both DUVV and LBV but most DUVV-seropositive bats (n = 32/220) also neutralised European bat lyssavirus 1 (EBLV-1) but not Rabies lyssavirus (RABV), the prototypic lyssavirus of phylogroup I. These results highlight that lyssaviruses belonging to phylogroups I and II circulate in regional bat populations and that the putative phylogroup I lyssavirus is antigenically closer to DUVV and EBLV-1 than to RABV. Variation between bat species, roost sites and bioclimatic regions were observed. All brain samples tested by RT-PCR specific for lyssavirus RNA were negative.

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“…In this study, CoV genomes containing regions resembling those of members of the genus Betacoronavirus were detected in Dobsonia moluccensis, known as Moluccan naked-backed fruit bat, in Indonesia. Dobsonia moluccensis belongs to family Pteropodidae, which is known to harbor a number of viruses, including CoVs [25,29], paramyxoviruses [18,30] and rhabdoviruses [29,31]. Nipah and Hendra viruses have also been detected in Dobsonia moluccensis [32,33].…”

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confidence: 99%

Detection of coronavirus genomes in Moluccan naked-backed fruit bats in Indonesia

et al. 2015

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1Bats have been shown to serve as natural reservoirs for numerous emerging viruses including the severe acute 2 respiratory syndrome coronavirus (SARS-CoV). In the present study, we report the discovery of bat CoV genes 3 in Indonesian Moluccan naked-back fruit bats (Dobsonia moluccensis). The partial RNA-dependent RNA 4 polymerase gene was detected in feces and tissues samples of the fruit bats and the helicase and a region 5 between the partial RdRp and partial helicase genes could also be amplified from fecal samples. Phylogenetic 6 analysis suggested the existence of these bat CoVs is related to the genus Betacoronavirus. 7 8

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Bat Lyssaviruses, Northern Vietnam

Cited by 9 publications

References 6 publications

Serological Evidence ofLyssavirusInfection among Bats in Nagaland, a North-Eastern State in India

Serological Evidence ofLyssavirusInfection among Bats in Nagaland, a North-Eastern State in India

Serological Evidence of Lyssaviruses among Bats on Southwestern Indian Ocean Islands

Detection of coronavirus genomes in Moluccan naked-backed fruit bats in Indonesia

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