Batch and microfluidic reactors in the synthesis of enteric drug carriers

Arruebo, Manuel; Sebastián, Víctor

doi:10.1016/b978-0-12-818038-9.00008-9

Cited by 6 publications

(4 citation statements)

References 130 publications

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“…Three Eudragit polymers were selected to enable targeted release in different locations of the GI tract. L-55 dissolution occurs above pH 5.5 thereby allowing duodenum targeting of the drug substance, L100 microcapsules should release cargo in the jejunum and S100 in the ileum and colon [ 24 ]. The pH responsive characteristics of Eudragit polymers depend upon the pKa of the carboxyl group, enabling dissolution at different pH values.…”

Section: Discussionmentioning

confidence: 99%

Microencapsulation of Bacteriophages Using Membrane Emulsification in Different pH-Triggered Controlled Release Formulations for Oral Administration

Richards¹,

Malik²

2021

Pharmaceuticals

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An E.coli-specific phage was encapsulated in three different pH responsive polymer formulations using the process of membrane emulsification. Small 100 µm capsules were fabricated and shown to afford phages suitable acid protection upon exposure to pH 1.5. Selection of polymer formulations allowed controlled release of phages at pH 5.5, pH 6 and pH 7. Other aspects of phage encapsulation including factors affecting encapsulation yield, release kinetics, acid and storage stability were evaluated. The work presented here would be useful for future evaluation of new therapeutic strategies including microbiome editing approaches allowing pH-triggered release of phages and delivery of encapsulated cargo to different intestinal compartments. The size of the capsules were selected to permit ease of delivery using small bore oral gavage tubes typically used in pre-clinical studies for evaluation of drug substances using small animal vertebrate models such as in mice and rats.

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Section: Discussionmentioning

confidence: 99%

Microencapsulation of Bacteriophages Using Membrane Emulsification in Different pH-Triggered Controlled Release Formulations for Oral Administration

Richards¹,

Malik²

2021

Pharmaceuticals

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“…Although SA is not classified as a classical nutrient, it has been suggested as a potential substrate for glucose in people with Type II diabetes and severe illness. This suggestion is made because the body may require large amounts of energy under stressful conditions when glucose utilization is significantly impaired due to decreased aerobic glycolysis and insulin resistance (Arruebo & Sebastian, 2020). In myoblasts (L6), SA dramatically stimulates glucose transporter4 expression and insulin‐mediated glucose uptake, and its oxidation increases the concentration of medium‐chain dicarboxylic acids (MCDAs), which can provide rapidly available energy (Iaconelli et al., 2010).…”

Section: Sa 10‐h2da and 10‐hdaamentioning

confidence: 99%

10‐hydroxy decanoic acid, trans‐10‐hydroxy‐2‐decanoic acid, and sebacic acid: Source, metabolism, and potential health functionalities and nutraceutical applications

Liao,

Alrosan,

Alu'datt

et al. 2024

Journal of Food Science

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The popularity of royal jelly (RJ) as a functional food has attracted attention from various industries, especially nutraceuticals, due to the increasing demand from health enthusiasts. Sebacic acid, 10‐hydroxy decanoic acid, and trans‐10‐hydroxy‐2‐decanoic acid are the primary medium‐chain fatty acids (MCFAs) within RJ responsible for their health benefits. This review aims to consolidate information on these MCFAs’ metabolic relationship and health functionalities in nutraceutical applications. We also investigated the natural characteristics mediated by these MCFAs and their metabolism in organisms. Finally, the production of these MCFAs using conventional (from castor oil) and alternative (from RJ) pathways was also discussed. This review can be a reference for using them as functional ingredients in nutraceutical industries.

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“…[33] Overall, NPs developed by MF systems are beneficial by providing new pathways to confront the challenges associated with conventional drug delivery methods. [67] The following sub-sections present and discuss the benefits of MFs-based NPs synthesis in various drug delivery methods.…”

Section: Advantages Of Microfluidic-based Nps In Drug Deliverymentioning

confidence: 99%

A Comprehensive Review of One Decade of Microfluidic Platforms Applications in Synthesis of Enhanced Carriers Utilized in Controlled Drug Delivery

Siavashy,

Soltani,

Ahmadi

et al. 2022

Adv Materials Technologies

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Physical and chemical characteristics of NPs highly depend on their shapes, sizes, structures, morphologies, surface properties, and chemical compositions, [8,9] which are modifiable. In addition, NPs can carry small molecules, imaging agents, deoxyribonucleic acid (DNA), antibodies, peptides, proteins, or other substances to specific parts of the body. [10,11] On the other hand, investigations on different diseases have confirmed the need for a paradigm shift in the development of drugs and delivery systems. Hence, developing novel therapeutics and delivery approaches to treat diseases is a significant problem. [12] Therefore, many novel strategies based on innovative solutions have been developed. [13][14][15] Among these strategies, the synthesis of nanocarriers using microfluidic (MF) technology has become popular in recent years. This multidisciplinary technology is a unique platform for chemistry, medicine, pharmacy, physics, biology, materials science, fluid mechanics, and engineering. [16,17] Specifically, it has played a pivotal role in developing drug delivery systems. [18][19][20] Therefore, it is crucial to study MF experiments' practical potential and advantages over conventional methods. Furthermore, considering a high surface-to-volume ratio in MFs, they require fewer chemical reagents and generate less waste, making them suitable for Novel nanocarriers such as multifunctional nanoparticles (NPs) have recently attracted attention due to their various applications, specifically in medicine and treatment. However, it is vital that these particles be synthesized with meticulous control of different structural, chemical, and physical properties. In response to this demand, microfluidic (MF) technology as a reliable procedure can provide promising results in the development of desired NPs and efficient drug delivery systems. By controlling the flow rates of multiphase fluids and conditions of chemical reactions, MF technology enables the fabrication of uniform and highly stable particles with enhanced surfaces, higher encapsulation efficiency, and controlled release of therapeutic agents compared with conventional bulk methods. This review article investigates the MF-based methods utilized in the synthesis of NPs and their advantages in developing novel drug delivery systems. It also provides a comprehensive comparison with conventional methods from a different point of view, emphasizing a novel category of nanocarriers' critical characteristics. In addition, a summary of the most recent representative works on NPs fabrication by MF procedures is presented, and their potential and applications in drug delivery are discussed.The ORCID identification number(s) for the author(s) of this article can be found under

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Batch and microfluidic reactors in the synthesis of enteric drug carriers

Cited by 6 publications

References 130 publications

Microencapsulation of Bacteriophages Using Membrane Emulsification in Different pH-Triggered Controlled Release Formulations for Oral Administration

Microencapsulation of Bacteriophages Using Membrane Emulsification in Different pH-Triggered Controlled Release Formulations for Oral Administration

10‐hydroxy decanoic acid, trans‐10‐hydroxy‐2‐decanoic acid, and sebacic acid: Source, metabolism, and potential health functionalities and nutraceutical applications

A Comprehensive Review of One Decade of Microfluidic Platforms Applications in Synthesis of Enhanced Carriers Utilized in Controlled Drug Delivery

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