Batch process particle separation using surface acoustic waves (SAW): integration of travelling and standing SAW

Devendran, Citsabehsan; Gunasekara, N.; Collins, Dave; Neild, Adrian

doi:10.1039/c5ra26965b

Cited by 63 publications

(50 citation statements)

References 56 publications

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“…The presence of the TBAWs reduces the Q value of the resonance state from previously reported values of 200-500 [41] to approximately 50, a value that, however, is large enough to ensure a well-defined resonance. While combinations of standing and traveling waves have been studied for surface-acoustic-wave systems [52][53][54][55], it is remarkable that they appear here in a study of bulkacoustic-wave (BAW) systems.…”

Section: A Analysis Of Capillary C1mentioning

confidence: 99%

Three-Dimensional Numerical Modeling of Acoustic Trapping in Glass Capillaries

Ley

Bruus

2017

Phys. Rev. Applied

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Acoustic traps are used to capture and handle suspended microparticles and cells in microfluidic applications. A particular simple and much-used acoustic trap consists of a commercially available, millimeter-sized, liquid-filled straight glass capillary actuated by a piezoelectric transducer. Here, we present a three-dimensional numerical model of the acoustic pressure field in the liquid coupled to the displacement field of the glass wall, taking into account mixed standing and traveling waves as well as absorption. The model explains the dynamical mechanism that leads to the formation of localized acoustic resonance modes in such a straight acoustic waveguide without any geometrical cavities in the axial direction of the capillary. The model further predicts that some of these modes are well suited for acoustic trapping, and it provides estimates for their frequencies and quality factors, the magnitude of the acoustic radiation force on a single test particle as a function of position, and the resulting acoustic retention force of the trap. We show that the model predictions are in agreement with published experimental results, and we discuss how improved and more-stable acoustic-trapping modes might be obtained using the model as a design tool.

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Section: A Analysis Of Capillary C1mentioning

confidence: 99%

Three-Dimensional Numerical Modeling of Acoustic Trapping in Glass Capillaries

Ley

Bruus

2017

Phys. Rev. Applied

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“…Although BAW‐based devices generally enable handling larger fluid volumes and throughputs, [ 51–53 ] SAW devices are advantageous for precise micromanipulation since they can achieve higher frequencies, [ 45,54 ] can readily localize the acoustic fields in specific regions, [ 38,55,56 ] and are a well‐established method for the precise spatial control of particles. [ 45 ] Periodic patterns of suspended particles are typically formed using standing surface acoustic waves (SSAWs), [ 57–60 ] though we recently demonstrated particle patterning using traveling SAWs via near‐field interference patterns formed near channel boundaries and in‐channel features. [ 61–63 ] The dissipation of acoustic energy in a liquid leads to acoustic streaming (a time‐averaged motion of the bulk liquid), resulting in a dominance of viscous drag forces over acoustic radiation forces for particles below a critical size, which can prevent acoustic trapping.…”

Section: Introductionmentioning

confidence: 99%

Massively Multiplexed Submicron Particle Patterning in Acoustically Driven Oscillating Nanocavities

Tayebi

O’Rorke

Wong

et al. 2020

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high-throughput particle manipulation for preparation, enrichment, and quality control. For example, the size distribution of synthesized nanoparticle catalysts determines their catalysis efficiency. [7,8] In biomedical applications, exosomes, which are submicron extracellular vesicles [9][10][11] containing DNA, microRNAs, and proteins, are a potential source of diagnostic biomarkers. [12][13][14][15] Suitable nanoparticle manipulation tools would enable sizebased sorting/filtering, or manipulation toward downstream activities such as multiplexed diagnostics, nanoelectronic/ robotic constructions, [16,17] and nanoparticle-based drug delivery systems. [18] Conventional particle separation techniques [19] are based on differential density and size, e.g., ultracentrifugation, [20] ultrafiltration, [21] and size exclusion chromatography. [22] Although impressive progress has been made in the last decade, many nanoparticle manipulation tools suffer from high cost, low throughput, and specimen damage. [23][24][25] Scalable nano-and submicron particle patterning has thus traditionally relied on self-assembly methods [26] or oligomer templating [27] however, these are largely unable to produce deterministic singlenanoparticle positioning, they are irreversible, and they require specific reagents or lengthy processing. [28][29][30] Moreover, drug delivery systems which incorporate efficient nanoparticle concentration are creating new avenues for cancer treatment. [31,32] There is, therefore, a pressing need to develop a fast, precise, and scalable method for nano-and submicron scale manipulation.Microfluidic devices have emerged as a viable platform for particle manipulation using magnetic, [33] optoelectronic, [34] plasmonic, [35] electrokinetic, [36] and hydrodynamic [37] forces. Applying these principles at the nanoscale instead of the microscale, however, can result in far smaller force magnitudes, poor separation efficiency, and channel clogging. [38] Furthermore, most of these manipulation methods are constrained by their dependence on particle polarizability, the need for low conductivity medium (which is often not biocompatible), and heating of the surrounding fluid. Optical tweezers [39,40] provide the highest degree of spatial resolution but they are usually applied in static fluids, owing to the relatively small forces that can be generated, [41] and only small numbers of nanoparticles can be manipulated at any one time (those within the Nanoacoustic fields are a promising method for particle actuation at the nanoscale, though THz frequencies are typically required to create nanoscale wavelengths. In this work, the generation of robust nanoscale force gradients is demonstrated using MHz driving frequencies via acoustic-structure interactions. A structured elastic layer at the interface between a microfluidic channel and a traveling surface acoustic wave (SAW) device results in submicron acoustic traps, each of which can trap individual submicron particles. The acoustically driven deformation of nanocavities gi...

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“…The interaction between SAW and fluid medium can result in acoustic streaming that moves cells along the fluid circulation. [91][92][93][94][95] Although acoustic cell enrichment has successfully separated the cancer cells of cell lines from WBCs, it has not been applied to the separation of rare CTCs from the clinical samples. It is mainly due to insufficient throughput.…”

Section: Acousticsmentioning

confidence: 99%

Microfluidics cell sample preparation for analysis: Advances in efficient cell enrichment and precise single cell capture

et al. 2017

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Single cell analysis has received increasing attention recently in both academia and clinics, and there is an urgent need for effective upstream cell sample preparation. Two extremely challenging tasks in cell sample preparation-highefficiency cell enrichment and precise single cell capture-have now entered into an era full of exciting technological advances, which are mostly enabled by microfluidics. In this review, we summarize the category of technologies that provide new solutions and creative insights into the two tasks of cell manipulation, with a focus on the latest development in the recent five years by highlighting the representative works. By doing so, we aim both to outline the framework and to showcase example applications of each task. In most cases for cell enrichment, we take circulating tumor cells (CTCs) as the target cells because of their research and clinical importance in cancer. For single cell capture, we review related technologies for many kinds of target cells because the technologies are supposed to be more universal to all cells rather than CTCs. Most of the mentioned technologies can be used for both cell enrichment and precise single cell capture. Each technology has its own advantages and specific challenges, which provide opportunities for researchers in their own area. Overall, these technologies have shown great promise and now evolve into real clinical applications. Published by AIP Publishing. [http://dx

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Batch process particle separation using surface acoustic waves (SAW): integration of travelling and standing SAW

Cited by 63 publications

References 56 publications

Three-Dimensional Numerical Modeling of Acoustic Trapping in Glass Capillaries

Three-Dimensional Numerical Modeling of Acoustic Trapping in Glass Capillaries

Massively Multiplexed Submicron Particle Patterning in Acoustically Driven Oscillating Nanocavities

Microfluidics cell sample preparation for analysis: Advances in efficient cell enrichment and precise single cell capture

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