Bats, Fever and Adenopathy – What Is the Link?

Manolakos, Joshua J.; Cooray, Mohan; Patel, Ameen; Haider, Shariq

doi:10.1155/2013/401565

Cited by 3 publications

(1 citation statement)

References 16 publications

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“…1,6,7 Since the first isolation by Emmons, [8][9][10] numerous studies have confirmed the presence of H. capsulatum in soils rich in nitrogen and phosphorus, such as soils containing bird and bat excrement. [10][11][12][13][14] In 1968, Lockwood and Garrison 15 demonstrated the ability of H. capsulatum to grow with different concentrations of nitrogen (N), which was shown to promote fungal growth. The same year, Brandsberg 16 described fungi isolated together from soils harboring H. capsulatum, but the author noted that a more complete physicochemical and microbiological characterization of the soils where H. capsulatum was isolated was needed to identify areas with a greater risk of infection.…”

Section: Introductionmentioning

confidence: 99%

Detection of Histoplasma capsulatum in Organic Fertilizers by Hc100 Nested Polymerase Chain Reaction and Its Correlation with the Physicochemical and Microbiological Characteristics of the Samples

Gómez

Torres

Jiménez-A

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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is the causative agent of histoplasmosis and this fungus inhabits soils rich in phosphorus and nitrogen that are enriched with bird and bat manure. The replacement of organic matter in agroecosystems is necessary in the tropics, and the use of organic fertilizers has increased. Cases and outbreaks due to the presence of the fungus in these components have been reported. The Instituto Colombiano Agropecuario resolution 150 of 2003 contains the parameters set by the Colombian Technical Standard (NTC 5167) on the physicochemical and microbiological features of fertilizers, but it does not regulate the search for . The aim of this study was to demonstrate presence in organic fertilizers by nested polymerase chain reaction (PCR). A total of 239 samples were collected: 201 (84.1%) corresponded to organic fertilizers, 30 (12.5%) to bird excrement, and 8 (3.4%) to cave soils. The Hc100 nested PCR had a detection limit of 0.1 pg/µL and a specificity of 100%. A total of 25 (10.5%) samples were positive and validated by sequencing. Seven of the positive samples represented locations where was previously detected, suggesting the persistence of the fungus. No significant correlations were detected between the physicochemical and microbiological parameters with the presence of by nested PCR, indicating the fungus existence in organic fertilizers that complied with the NTC 5167. The Hc100 nested PCR targeting standardized in this work will improve the evaluation of organic fertilizers and ensure the prevention of outbreaks and cases due to manufacturing, marketing, and use of fertilizers contaminated with.

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Section: Introductionmentioning

confidence: 99%

Detection of Histoplasma capsulatum in Organic Fertilizers by Hc100 Nested Polymerase Chain Reaction and Its Correlation with the Physicochemical and Microbiological Characteristics of the Samples

Gómez

Torres

Jiménez-A

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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Treatment of the Midwestern Endemic Mycoses, Blastomycosis and Histoplasmosis

Kauffman

2017

Curr Fungal Infect Rep

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Acute histoplasmosis in immunocompetent travelers: a systematic review of literature

et al. 2018

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BackgroundHistoplasmosis is a fungal infection highly endemic in the American continent. The disease can be severe in immunocompromised subjects. In immunocompetent subjects the clinical manifestations are variable. Aim of this work was to review the cases of acute histoplasmosis in immunocompetent travelers reported in literature.MethodsA systematic review of literature was conducted. Electronic search was performed in Pubmed and LILACS. Two reviewers independently extracted data on demographic, clinical and radiological features, and treatment. Cases were classified according to Wheat’s definitions.ResultsSeventy-one studies were included in the analysis, comprising a total of 814 patients. Twenty-one patients diagnosed at the Centre of Tropical Diseases, Negrar (VR), Italy were also included. The most common travel destination was Central America (168 people, 29.8%); the most common way of exposure to histoplasma was the exploration of caves and/or contact with bat guano (349 people, 60.9%). The multivariate logistic regression model showed association between the development of disseminated histoplasmosis (DH) and activities that involved the exploration of caves and/or the contact with bats’ guano (adjusted OR: 34.20 95% CI: 5.29 to 220.93) or other outdoor activities (adjusted OR: 4.61 95% CI: 1.09 to 19.56). No significant difference in the attack rate between countries of destination was observed (p-value: 0.8906, Kruskal-Wallis test).ConclusionsHistoplasmosis often causes no or mild symptoms in immunocompetent individuals, although a severe syndrome may occur. The infection can mimic other diseases, and the epidemiological risk of exposure is an important clue to raise the index of suspicion.Electronic supplementary materialThe online version of this article (10.1186/s12879-018-3476-z) contains supplementary material, which is available to authorized users.

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Bats, Fever and Adenopathy – What Is the Link?

Cited by 3 publications

References 16 publications

Detection of Histoplasma capsulatum in Organic Fertilizers by Hc100 Nested Polymerase Chain Reaction and Its Correlation with the Physicochemical and Microbiological Characteristics of the Samples

Detection of Histoplasma capsulatum in Organic Fertilizers by Hc100 Nested Polymerase Chain Reaction and Its Correlation with the Physicochemical and Microbiological Characteristics of the Samples

Treatment of the Midwestern Endemic Mycoses, Blastomycosis and Histoplasmosis

Acute histoplasmosis in immunocompetent travelers: a systematic review of literature

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