Treatment of the Midwestern Endemic Mycoses, Blastomycosis and Histoplasmosis

Kauffman, Carol A.

doi:10.1007/s12281-017-0281-x

Cited by 11 publications

(7 citation statements)

References 58 publications

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“…In mild to moderate disease, itraconazole is the first line therapy [ 14 , 15 ]. The use of newer azole agents like posaconazole is less well studied, although in some case reports it appears to be an effective alternative to itraconazole [ 16 ]. In conclusion, this case highlights the challenging aspect of diagnosing histoplasmosis after solid organ transplantation in non-endemic areas where this disease is rarely taken into consideration.…”

Section: Discussionmentioning

confidence: 99%

Disseminated histoplasmosis in a kidney liver transplant patient from a non-endemic area: A diagnostic challenge

Carmans¹,

Craenenbroeck

Lagrou

et al. 2020

IDCases

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Disseminated histoplasmosis is a rare opportunistic infection in non-endemic areas, where the disease is often diagnosed late. The spectrum of clinical manifestations is broad and life-threatening complications occur. We present a detailed case of a kidney liver transplant patient with disseminated histoplasmosis in a non-endemic area. Our case highlights the wide range of pathogens to consider in the immunocompromised patient, the delayed diagnosis of Histoplasmosis Capsulatum in non-endemic areas and the possibility of severe gastrointestinal disease. We also briefly review diagnostic tests and treatment options.

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Section: Discussionmentioning

confidence: 99%

Disseminated histoplasmosis in a kidney liver transplant patient from a non-endemic area: A diagnostic challenge

Carmans¹,

Craenenbroeck

Lagrou

et al. 2020

IDCases

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“…Las manifestaciones dermatológicas de la histoplasmosis diseminada representan 17% de los casos, casi siempre asociadas con algún grado de inmunodeficiencia en el hospedero 7 . Estas dermatosis se clasifican en dos grupos, independiente de si los pacientes tienen o no infección por VIH.…”

Section: Discussionunclassified

Lesiones cutáneas como manifestación de una histoplasmosis diseminada en un hospital del Perú

Cubas¹,

Jiménez²,

Vega³

2017

Rev. chil. infectol.

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Comunicación BreveLesiones cutáneas como manifestación de una histoplasmosis diseminada en un hospital del Perú W. Samir Cubas, Gerardo Jiménez y Juan Vega Skin lesions of a disseminated histoplasmosis in PeruThe dermatological manifestations of disseminated histoplasmosis present in about 17% of the cases, is a challenge for its diagnosis. We report the case of a patient from the northern coast of Peru, who presented diffuse dermal lesions, erythema-violaceous nodules, and ulcers histopathologically compatible with the infection of the genus Histoplasma var. capsulatum

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“…100 Reported experience with posaconazole is limited, but this agent has been used successfully as second line therapy for patients with blastomycosis. [101][102][103] The dose is 300 mg twice daily for the first day and then 300 mg daily after that. Absorption is excellent with the extended-release tablet formulation, but it is wise to obtain therapeutic drug monitoring to ensure satisfactory serum concentrations greater than 1 μg/mL.…”

Section: Mild To Moderate Pulmonary or Disseminated Blastomycosismentioning

confidence: 99%

Blastomycosis

Schwartz

Kauffman

2020

Semin Respir Crit Care Med

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Blastomycosis is a serious fungal disease of humans and other mammals caused by environmentally acquired infection with geographically restricted, thermally dimorphic fungi belonging to the genus Blastomyces. The genetic and geographic diversity of these pathogens is greater than previously appreciated. In addition to Blastomyces dermatitidis and the cryptic species Blastomyces gilchristii, which cause blastomycosis in mid-western and various eastern areas of North America, atypical blastomycosis is occasionally caused by Blastomyces helicus in western parts of North America and Blastomyces percursus in Africa. Blastomycosis is acquired by inhalation of the conidia that are produced in the mold phase; in the lungs, temperature-dependent transformation occurs to the yeast phase. In this form, the organism is phagocytized by macrophages and can spread hematogenously to various organs causing disseminated infection. Pulmonary disease is most common and varies from mild, self-limited infection to severe, potentially fatal adult respiratory distress syndrome. Disseminated infection is manifested primarily by skin lesions, but many other organs can be involved. Diagnosis is established by growth of the organism in culture; however, a tentative diagnosis can be made quickly by histopathological identification of the classic yeast form in tissues or by finding Blastomyces antigen in urine or serum. Blastomycosis is treated initially with amphotericin B when the disease is severe, involves the central nervous system, or the host is immunosuppressed. Itraconazole is recommended for primary therapy in mild-to-moderate infection and for step-down therapy after initial amphotericin B treatment. Voriconazole and posaconazole can be used for patients in whom itraconazole is not tolerated.

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Treatment of the Midwestern Endemic Mycoses, Blastomycosis and Histoplasmosis

Cited by 11 publications

References 58 publications

Disseminated histoplasmosis in a kidney liver transplant patient from a non-endemic area: A diagnostic challenge

Disseminated histoplasmosis in a kidney liver transplant patient from a non-endemic area: A diagnostic challenge

Lesiones cutáneas como manifestación de una histoplasmosis diseminada en un hospital del Perú

Blastomycosis

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