The interface between computer science and statistics has developed considerably in recent years, with exponential progress in the fields of data analysis, stochastic modeling, machine learning, econometrics, simulation, algorithms, classification, and networks. Innovative discoveries in this field appear every day, opening new scientific horizons for the modern world. This is especially true in the post-2020 period, with the treatment of large volumes of data that feed the daily operations of large corporations, as well as the development of artificial intelligence, including advanced machine learning techniques, particularly "deep learning".The aim of the special issue titled "New Trends in Statistical Computing and Data Science" was to publish the most significant articles in these directions, that is, the current progress of statistical computing and data science. Novelty, high quality, and importance are the triptych of the special issue.