Bayesian population pharmacokinetic modeling of florfenicol in pigs after intravenous and intramuscular administration

Liu, Zhichang; Rong, Ting; Zeng, Dongping; Shen, Xiu; Ma, Xianyong; Zeng, Zhenling

doi:10.1111/jvp.12677

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…The pharmacokinetics of florfenicol in pigs have already been investigated in plasma and the lung. The pharmacokinetic properties of florfenicol vary widely between individual pigs [ 28 ]. Overall, it has excellent absorption and distribution in the pig body system, with a very low binding to plasma protein [ 24 , 28 , 29 , 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

“…The pharmacokinetic properties of florfenicol vary widely between individual pigs [ 28 ]. Overall, it has excellent absorption and distribution in the pig body system, with a very low binding to plasma protein [ 24 , 28 , 29 , 30 , 31 , 32 ]. In a previous study, we investigated the pharmacokinetics of florfenicol in pig synovial fluid at a dose of 15 mg/kg bw following a single intramuscular administration.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics and Pharmacodynamics of Florfenicol in Plasma and Synovial Fluid of Pigs at a Dose of 30 mg/kgbw Following Intramuscular Administration

et al. 2023

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A major problem of our time is the ever-increasing resistance to antimicrobial agents in bacterial populations. One of the most effective ways to prevent these problems is to target antibacterial therapies for specific diseases. In this study, we investigated the in vitro effectiveness of florfenicol against S. suis, which can cause severe arthritis and septicemia in swine herds. The pharmacokinetic and pharmacodynamic properties of florfenicol in porcine plasma and synovial fluid were determined. After a single intramuscular administration of florfenicol at 30 mg/kgbw, the AUC0–∞ was 164.45 ± 34.18 µg/mL × h and the maximum plasma concentration was 8.15 ± 3.11 µg/mL, which was reached in 1.40 ± 0.66 h, whereas, in the synovial fluid, these values were 64.57 ± 30.37 µg/mL × h, 4.51 ± 1.16 µg/mL and 1.75 ± 1.16 h, respectively. Based on the MIC values of the 73 S. suis isolates tested, the MIC50 and MIC90 values were 2 µg/mL and 8 µg/mL, respectively. We successfully implemented a killing–time curve in pig synovial fluid as a matrix. Based on our findings, the PK/PD breakpoints of the bacteriostatic (E = 0), bactericidal (E = −3) and eradication (E = −4) effects of florfenicol were determined and MIC thresholds were calculated, which are the guiding indicators for the treatment of these diseases. The AUC24h/MIC values for bacteriostatic, bactericidal and eradication effects were 22.22 h, 76.88 h and 141.74 h, respectively, in synovial fluid, and 22.42 h, 86.49 h and 161.76 h, respectively, in plasma. The critical MIC values of florfenicol against S. suis regarding bacteriostatic, bactericidal and eradication effects in pig synovial fluid were 2.91 ± 1.37 µg/mL, 0.84 ± 0.39 µg/mL and 0.46 ± 0.21 µg/mL, respectively. These values provide a basis for further studies on the use of florfenicol. Furthermore, our research highlights the importance of investigating the pharmacokinetic properties of antibacterial agents at the site of infection and the pharmacodynamic properties of these agents against different bacteria in different media.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics and Pharmacodynamics of Florfenicol in Plasma and Synovial Fluid of Pigs at a Dose of 30 mg/kgbw Following Intramuscular Administration

et al. 2023

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In vivo pharmacokinetic and pharmacodynamic study and cutoff of florfenicol against Riemerella anatipestifer in ducks

Zhang,

Li,

Chen

et al. 2025

Poultry Science

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Florfenicol 40% efficacy in piglets with respiratory pathologies

Engashev

Savinkov²,

Sadov³

et al. 2022

BIO Web Conf.

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Piglets with large-scale respiratory pathologies caused by a bacterial flora susceptible to phenicol antibacterial drugs received two doses of Florfenicol 40%. On day 4 after administration, this resulted in the complete reversal of clinical pattern, in the recovery of morphofunctional blood parameters, and in the reduction in prevalence of Klebsiella pneumoniae by 25%, Streptococcus suis by 50%, and Staphylococcus haemolyticus by 41.7%. The drug is tolerated with no adverse events. The results of this study allow recommending Florfenicol 40% as an antibacterial therapy in the acute infectious inflammatory respiratory pathologies in the store pigs.

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Bayesian population pharmacokinetic modeling of florfenicol in pigs after intravenous and intramuscular administration

Cited by 3 publications

References 21 publications

Pharmacokinetics and Pharmacodynamics of Florfenicol in Plasma and Synovial Fluid of Pigs at a Dose of 30 mg/kgbw Following Intramuscular Administration

Pharmacokinetics and Pharmacodynamics of Florfenicol in Plasma and Synovial Fluid of Pigs at a Dose of 30 mg/kgbw Following Intramuscular Administration

In vivo pharmacokinetic and pharmacodynamic study and cutoff of florfenicol against Riemerella anatipestifer in ducks

Florfenicol 40% efficacy in piglets with respiratory pathologies

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