Bazex syndrome (acrokeratosis paraneoplastica)

Sarkar, B.; Knecht, Rainald; Sarkar, Chitra; Weidauer, H.

doi:10.1007/s004050050044

Cited by 34 publications

(29 citation statements)

References 16 publications

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“…The etiology of Bazex syndrome is still unknown, although, several hypotheses have been suggested such as immunologic mechanisms in which antibodies directed against the tumour cross-react with antigens in the epidermis or basement membrane; a possible tumour's capability to secrete growth factors, e.g., TGF-alpha that may affects epidermal growth and epithelial differentiation; and genetic susceptibility due to the occurrence of the same HLA types (A3 and B8) in many cases of the disease [8,[10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Bazex Syndrome (Acrokeratosis Paraneoplastica) Diagnosed in a Patient with Oral Persistent Ulcerations

Santos‐Silva

Corrêa²,

Vargas

et al. 2010

Head and Neck Pathol

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Paraneoplastic syndromes associated with head and neck cancer are rare and have been reported under dermatological, endocrine, hematological, neurological and rheumatological disorders. Bazex syndrome is an intriguing paraneoplasia that can be associated with head and neck squamous cell carcinomas. A range of symmetrical dermatological manifestations, with a clear predilection to extremities, that encompasses erythematous squamous plaques, skin scaling and nail dystrophy can provide a psoriasiform pattern in Bazex syndrome. In addition to these tricky clinical features, the rarity of the disease and the lack of understanding on Bazex syndrome generally make such cases to be mismanaged as psoriasis or lichen planus, causing an important delay in the diagnosis of the underlying malignancy. The authors describe a case of Bazex syndrome that occurred in a patient with a recently diagnosed tongue squamous cell carcinoma. Clinicians should consider paraneoplasia when assessing skin and/or oral persistent lesions.

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Section: Discussionmentioning

confidence: 99%

Bazex Syndrome (Acrokeratosis Paraneoplastica) Diagnosed in a Patient with Oral Persistent Ulcerations

Santos‐Silva

Corrêa²,

Vargas

et al. 2010

Head and Neck Pathol

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“…Can cers that are ra rely co-pre sent with Ba zex syndro me inc lu de pros ta te, uri nary blad der, li ver, sto mach, co lon, thymus, ute rus, vul va as well as mye lo mas. 13 Our ca se had Ba zex syndro me as so cia ted with me tas ta tic lung car ci no ma with an in defi ni te pri mary si te. Accor ding to our pre sent know led ge, the re is no reports in the li te ra tu re that men ti o ned a ca se of Ba zex syndro me as so ci ated with me tas ta tic lung car ci no ma.…”

Section: Discussionmentioning

confidence: 99%

“…2,3,5,6,13 Chan ges in na ils are pa rony chi a, su bungal hyper ke ra to sis, yel low dis co lo ra ti on and onycholy sis. 2,3,5,6,13 The li te ra tu re inc lu des only a few ca ses of Ba zex syndro me ac com pa ni ed by bul lo us le si ons.…”

Section: Deri Ve Zührevi Hastalıklarmentioning

confidence: 99%

Pustular Bazex Syndrome with Flexural Localization Associated with Metastatic Lung Carcinoma: Case Report

Çiçek¹,

Kandı²,

Demir³

et al. 2011

Turkiye Klinikleri J Med Sci

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“…Zespół jest częstszy u mężczyzn (wg niektórych danych stanowią oni 94% opisywanych przypadków) i przeważnie współistnieje z rakiem krtani, rzadziej jamy ustnej, gardła, przełyku i płuc, Przegląd Dermatologiczny 2017/1 a rzadko z innymi nowotworami, m.in. rakiem jelita grubego [38,39]. Patogeneza nie jest dokładnie poznana.…”

Section: Zespół Bazexaunclassified

Dermatologic symptoms associated with gastrointestinal neoplasia

Młynarczyk-Bonikowska¹,

Muszyński²,

Majewski³

2017

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StreSzczenieNowotwory układu pokarmowego należą do najczęściej występujących chorób i są również jedną z najczęstszych nowotworowych przyczyn zgonów na świecie. Obecność charakterystycznych zmian skórnych pozwala na szybsze rozpoznanie i leczenie, a tym samym zwiększenie prawdopodobieństwa wyleczenia. W artykule przedstawiono najważ-niejsze skórne zespoły paraneoplastyczne, które mogą współistnieć z nowotworami przewodu pokarmowego, w tym rakiem jelita grubego, żołądka i przełyku oraz trzustki. Uwzględniono zespoły uwarunkowane genetycznie, takie jak zespół Cowden, zespół rodzinnie występu-jących licznych znamion atypowych -czerniak lub rak trzustki, zespoły Clarke Howela-Evansa, Peutza-Jeghersa, Muira-Torrego, Gardnera, zespoły nabyte, takie jak rogowacenie ciemne złośliwe, zespół tripe palms, Lesera-Trelat, Bazexa, hypertrichosis lanuginosa, erythema gyratum repens, zespół rakowiaka, zespół glukagonoma, a także przerzuty nowotworowe do skóry oraz nowotwory w niektórych przypadkach zapalenia skórno-mięśniowego. AbStrActGastrointestinal tumors are among the most common neoplastic causes of death worldwide. Presence of characteristic skin lesions can allow faster diagnosis and therapy and this way can increase the probability of a cure. In the paper we present the most important paraneoplastic syndromes that can coexist with gastrointestinal malignancy including colon, gastric, esophagus and pancreatic cancers. We take into account genetic syndromes such as Cowden syndrome, familial atypical multiple mole melanoma syndrome (FAMMM) (melanoma/pancreatic cancer), Clarke Howel-Evans, Peutz-Jeghers, Muir-Torre, Gardner syndromes and acquired syndromes such as acantosis nigricans maligna, tripe palms, Leser-Trelat, Bazex, hypertrichosis languinosa, erythema gyratum repens, carcinoid and glucagonoma syndrome. We also include cutaneous metastases and coexistence of neoplasia in some cases of dermatomyositis.

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Bazex syndrome (acrokeratosis paraneoplastica)

Cited by 34 publications

References 16 publications

Bazex Syndrome (Acrokeratosis Paraneoplastica) Diagnosed in a Patient with Oral Persistent Ulcerations

Bazex Syndrome (Acrokeratosis Paraneoplastica) Diagnosed in a Patient with Oral Persistent Ulcerations

Pustular Bazex Syndrome with Flexural Localization Associated with Metastatic Lung Carcinoma: Case Report

Dermatologic symptoms associated with gastrointestinal neoplasia

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