BaZiBuShen alleviates cognitive deficits and regulates Sirt6/NRF2/HO-1 and Sirt6/P53-PGC-1α-TERT signaling pathways in aging mice

Li, Lin; Zhang, Hao; Chen, Beibei; Xia, Bingke; Zhu, Ruyuan; Liu, Yage; Xuan, Dong; Ye, Zimengwei; Zhao, Dandan; Mo, Fangfang; S, Gao; Orekhov, Alexander N.; Prentki, Marc; Wang, Lili; Guo, Shuzhen; Zhang, Dongwei

doi:10.1016/j.jep.2021.114653

Cited by 23 publications

(34 citation statements)

References 89 publications

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“…This compound also increased mitochondrial oxygen consumption rate and Complex IV activity. Finally, BZBS preserved SIRT6 expression in the aging model (Li et al, 2022). There are some examples of SIRT6 playing a deleterious role in OS, however, most of the evidence suggests SIRT6 protects against OS through enhancing genomic stability and facilitating NRF2.…”

Section: Nuclear Sirtuinsmentioning

confidence: 82%

Sirtuins and cognition: implications for learning and memory in neurological disorders

et al. 2022

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Sirtuins are an evolutionarily conserved family of regulatory proteins that function in an NAD+ -dependent manner. The mammalian family of sirtuins is composed of seven histone deacetylase and ADP-ribosyltransferase proteins (SIRT1-SIRT7) that are found throughout the different cellular compartments of the cell. Sirtuins in the brain have received considerable attention in cognition due to their role in a plethora of metabolic and age-related diseases and their ability to induce neuroprotection. More recently, sirtuins have been shown to play a role in normal physiological cognitive function, and aberrant sirtuin function is seen in pathological cellular states. Sirtuins are believed to play a role in cognition through enhancing synaptic plasticity, influencing epigenetic regulation, and playing key roles in molecular pathways involved with oxidative stress affecting mitochondrial function. This review aims to discuss recent advances in the understanding of the role of mammalian sirtuins in cognitive function and the therapeutic potential of targeting sirtuins to ameliorate cognitive deficits in neurological disorders.

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Section: Nuclear Sirtuinsmentioning

confidence: 82%

Sirtuins and cognition: implications for learning and memory in neurological disorders

et al. 2022

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“…As for the countries where the experiments were conducted, China had the most cases (n = 20) [ 8 , 9 , 13 , 15 , 16 , 19 , 23 , 26 , 27 , 28 , 29 , 30 , 32 , 36 , 38 , 39 , 46 , 47 , 48 , 49 ], followed by Japan (n = 8) [ 12 , 20 , 40 , 41 , 42 , 43 , 44 , 45 ], Korea (n = 6) [ 24 , 31 , 33 , 34 , 35 , 37 ] and Taiwan (n = 3) [ 21 , 22 , 23 ]. Thailand [ 18 ], the United States [ 17 ], Mexico [ 11 ] and Poland [ 25 ] were each associated with one study.…”

Section: Resultsmentioning

confidence: 99%

“…In herbal medicine extraction, 17 studies used water extraction [ 9 , 13 , 14 , 17 , 20 , 21 , 22 , 27 , 31 , 33 , 39 , 40 , 42 , 45 , 47 , 48 ]; 6 studies used ethanol [ 10 , 16 , 18 , 24 , 34 , 35 ]; and 2 studies used carbon dioxide fluid [ 23 , 26 ]. Three studies used a suspension of the herbal formula Guilingji [ 15 , 29 , 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…One study did not report the route of administration [ 11 ]. Eighteen studies tested the dose of herbal medicine at a single concentration [ 11 , 13 , 17 , 18 , 19 , 20 , 21 , 24 , 28 , 31 , 37 , 38 , 39 , 40 , 42 , 46 , 48 , 50 ], and in 21 studies, 2 or 3 types of concentrations were tested [ 8 , 9 , 10 , 14 , 15 , 16 , 22 , 23 , 25 , 26 , 27 , 29 , 30 , 32 , 33 , 34 , 35 , 36 , 41 , 45 , 47 ]. The other two studies did not report the dosage used [ 12 , 44 ].…”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review of In Vivo Studies of the Efficacy of Herbal Medicines for Anti-Aging in the Last Five Years

et al. 2023

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Background: The world’s population is rapidly aging, and attention to and research on the increase in life expectancy and age-related diseases are needed. This study aimed to review the in vivo studies on the anti-aging effects of herbal medicines. Methods: In vivo studies of single or complex herbal medicines for anti-aging that were published in the last five years were included in this review. The following databases were used: PubMed, Scopus, ScienceDirect, Web of Science and EMBASE. Results: A total of 41 studies were considered eligible for the review. The articles were classified into body organs and functions, experimental country, herbal medicine, extraction method, administration route, dosage, duration, animal model, aging-induced method, sex, number of animals per group, and outcomes and mechanisms A single herbal extract was used in a total of 21 studies including Alpinia oxyphylla Miq., Acanthopanax senticosus and Lyceum barbarum, and a multi-compound herbal prescription was used in a total of 20 studies, including Modified Qiongyu paste, Wuzi Yanzong recipe, etc. Each herbal medicine had anti-aging effects on learning and memory, cognition, emotion, internal organs, gastrointestinal tracts, sexual functions, musculoskeletal function and so on. The common mechanisms of action were antioxidant and anti-inflammatory, and various effects and mechanisms for each organ and function were identified. Conclusions: Herbal medicine exhibited beneficial effects on anti-aging in various parts of the body and its function. Further investigation of the appropriate herbal medicine prescriptions and their components is recommended.

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“…Additionally, BZBS is effective at ameliorating brain function decline in d -gal- and NaNO 2 -induced ageing mice, which may be associated with protecting redox homeostasis, telomere integrity, apoptosis inhibition, and activation of the Sirt6/P53-PGC-1α-TERT and Sirt6/NRF2/HO-1 signalling pathway (Li et al. 2022 ). Currently, the mechanism of BZBS delaying ageing and improving brain ageing still needs further research.…”

Section: Introductionmentioning

confidence: 99%

Bazi Bushen capsule attenuates cognitive deficits by inhibiting microglia activation and cellular senescence

Shen

et al. 2022

Pharmaceutical Biology

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Context Bazi Bushen capsule (BZBS) has anti-ageing properties and is effective in enhancing memory. Objective To find evidence supporting the mechanisms and biomarkers by which BZBS functions. Materials and methods Male C57BL/6J mice were randomly divided into five groups: normal, ageing, β-nicotinamide mononucleotide capsule (NMN), BZBS low-dose (LD-BZ) and BZBS high-dose (HD-BZ). The last four groups were subcutaneously injected with d -galactose ( d -gal, 100 mg/kg/d) to induce the ageing process. At the same time, the LD-BZ, HD-BZ and NMN groups were intragastrically injected with BZBS (1 and 2 g/kg/d) and NMN (100 mg/kg/d) for treatment, respectively. After 60 days, the changes in overall ageing status, brain neuron morphology, expression of p16 INK4a , proliferating cell nuclear antigen (PCNA), ionized calcium-binding adapter molecule 1 (Iba1), postsynaptic density protein 95 (PSD95), CD11b, Arg1, CD206, Trem2, Ym1 and Fizz1, and the senescence-associated secretory phenotype (SASP) factors were observed. Results Compared with the mice in the ageing group, the HD-BZ mice exhibited obvious improvements in strength, endurance, motor coordination, cognitive function and neuron injury. The results showed a decrease in p16 INK4a , Iba1 and the upregulation of PCNA, PSD95 among brain proteins. The brain mRNA exhibited downregulation of Iba1 ( p < 0.001), CD11b ( p < 0.001), and upregulation of Arg1 ( p < 0.01), CD206 ( p < 0.05), Trem2 ( p < 0.001), Ym1 ( p < 0.01), Fizz1 ( p < 0.05) and PSD95 ( p < 0.01), as well as improvement of SASP factors. Conclusions BZBS improves cognitive deficits via inhibition of cellular senescence and microglia activation. This study provides experimental evidence for the wide application of BZBS in clinical practice for cognitive deficits.

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BaZiBuShen alleviates cognitive deficits and regulates Sirt6/NRF2/HO-1 and Sirt6/P53-PGC-1α-TERT signaling pathways in aging mice

Cited by 23 publications

References 89 publications

Sirtuins and cognition: implications for learning and memory in neurological disorders

Sirtuins and cognition: implications for learning and memory in neurological disorders

A Systematic Review of In Vivo Studies of the Efficacy of Herbal Medicines for Anti-Aging in the Last Five Years

Bazi Bushen capsule attenuates cognitive deficits by inhibiting microglia activation and cellular senescence

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