BCAA-enriched snack improves nutritional state of cirrhosis

Nakaya, Yutaka; Okita, Kiwamu; Suzuki, Kazuyuki; Moriwaki, Hisataka; Kato, Akinobu; Miwa, Yoshiyuki; Shiraishi, Koji; Okuda, Hiroyuki; Onji, Morikazu; Kanazawa, Hideko; Tsubouchi, Hirohito; Kato, Shinichi; Kaito, Masahiko; Watanabe, Akïharu; Habu, Daiki; Ito, Susumu; Ishikawa, Tomohisa; Kawamura, Naohiro; Arakawa, Yasuyuki

doi:10.1016/j.nut.2006.10.008

Cited by 185 publications

(241 citation statements)

References 29 publications

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“…The administration of BCAA has been reported to not only reduce malnutrition and improve energy metabolism, but also to improve the liver function and quality of life of patients with cirrhosis [157][158][159] . However, BCCA supplementation may be harmful because glucose intolerance can be exhibited by cirrhotic livers [55] .…”

Section: Nutritional Abnormalities In Liver Diseasesmentioning

confidence: 99%

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Systemic abnormalities in liver disease

Minemura¹,

Tajiri²,

Shimizu³

2009

WJG

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Section: Nutritional Abnormalities In Liver Diseasesmentioning

confidence: 99%

“…In addition, hepatic glycogen stores decrease in patients with liver cirrhosis because of liver atrophy, leading to the development of a severe catabolic state after fasting. Late evening snacks including BCAA are recommended in order to avoid such problems during the night-time [158,159] .…”

Section: Nutritional Abnormalities In Liver Diseasesmentioning

confidence: 99%

Systemic abnormalities in liver disease

Minemura¹,

Tajiri²,

Shimizu³

2009

WJG

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“…The reason for this is that, RFA, which has high curability, was used more often in the early period than during other periods. On the other hand, it is well known that BCAA formulations are effective for maintaining the Alb level in patients with cirrhosis (Nakaya et al 2007). However, there is no report in which multiple measurements of BCAA and Alb were performed in matched HCC patients with recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…In clinical situations, BCAA formulations are commonly used to maintain the Alb level (Nakaya et al 2007) and prevent ascites in patients with cirrhosis, because BCAA promote Alb secretion through the mTOR signal pathway in liver (Matsumura et al 2005). Long-term nutritional supplementation with oral BCAA has been shown to be useful to prevent progressive hepatic failure and to improve surrogate markers and the perceived health status (Marchesini et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Supplementation of Branched-Chain Amino Acids Maintains the Serum Albumin Level in the Course of Hepatocellular Carcinoma Recurrence

Kakazu

Kondo

Kogure

et al. 2013

Tohoku J. Exp. Med.

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Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. Serum albumin (Alb) is an important prognostic factor for patients with HCC. Moreover, plasma levels of branched-chain amino acids (BCAA), L-valine, L-leucine, and L-isoleucine, are commonly decreased in patients with cirrhosis. Accordingly, formulations of BCAA has been used to maintain the Alb level and prevent ascites in patients with cirrhosis. The aim of this study is to investigate differences in the changes in Alb between a group that received a BCAA formulation (n = 29) and a group given a standard diet (n = 60) in the course of HCC recurrences. All patients experienced more than one hospitalization (mean: 2.6; range: 2-10) owing to recurrence. The plasma BCAA concentration and BCAA-to-tyrosine ratio (BTR), which is a good indicator of the severity of hepatic parenchymal injury in patients with cirrhosis, were significantly correlated with Alb. We defined the changes in BCAA and Alb between recurrences as ΔBCAA and ΔAlb, respectively, and stratified the patients in both groups based on number of recurrences (3 < early, 3-5 middle, or 5 > later). There was also a positive correlation between ΔBCAA and ΔAlb. Interestingly, in the group with BCAA, ΔAlb and ΔBCAA were significantly smaller, especially in the middle period (3-5 recurrences), than in the group without BCAA. These results indicate that the BCAA supplementation could maintain the BCAA and Alb levels in the middle period (3-5 recurrences). BCAA formulation is useful for hypoalbuminemia in the course of HCC recurrence.

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“…53 Nocturnal supplementations with snacks enriched with branched chain amino acids (BCAA) have also been suggested to be effective in improving the nutritional status of cirrhotic patients 54 being even better than the supplements of ordinary food. 55 Main nutritional recommendations in liver cirrhosis are summarized in Table 5.…”

Section: Indications For Malnourished Patients Waiting For Liver Tranmentioning

confidence: 99%

Nutritional Status and Liver Transplantation

Merli¹,

Giusto²,

Giannelli³

et al. 2011

Journal of Clinical and Experimental Hepatology

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Chronic liver disease has a profound effect on nutritional status and undernourishment is almost universally present in patients with end-stage liver disease undergoing liver transplantation. In the last decades, due to epidemiological changes, a trend showing an increase in patients with end-stage liver disease and associated obesity has also been reported in developed countries. Nutrition abnormalities may influence the outcome after transplantation therefore, the importance to carefully assess the nutritional status in the work-up of patients candidates for liver transplantation is widely accepted. More attention has been given to malnourished patients as they represent the greater number. The subjective global nutritional assessment and anthropometric measurements are recognized in current guidelines to be adequate in identifying those patients at risk of malnutrition. Cirrhotic patients with a depletion in lean body mass and fat deposits have an increased surgical risk and malnutrition may impact on morbidity, mortality and costs in the post-transplantation setting. For this reason an adequate calorie and protein intake should always be ensured to malnourished cirrhotic patient either through the diet, or using oral nutritional supplements or by enteral or parenteral nutrition although studies supporting the efficacy of nutritional supplementation in improving the clinical outcomes after transplantation are still scarce. When liver function is restored, an amelioration in the nutritional status is expected. After liver transplantation in fact dietary intake rapidly normalizes and fat mass is progressively regained while the recovery of muscle mass can be slower. In some patients unregulated weight gain may lead to over-nutrition and may favor metabolic disorders (hypertension, hyperglycemia, hyperlipidemia). This condition, defined as 'metabolic syndrome', may play a negative role on the overall survival of liver transplant patients. In this report we review data on nutrition and liver transplantation. © 2011 INASL

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BCAA-enriched snack improves nutritional state of cirrhosis

Cited by 185 publications

References 29 publications

Systemic abnormalities in liver disease

Systemic abnormalities in liver disease

Supplementation of Branched-Chain Amino Acids Maintains the Serum Albumin Level in the Course of Hepatocellular Carcinoma Recurrence

Nutritional Status and Liver Transplantation

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