bcl-2 Protein Expression and Correlation with the Interchromosomal 14;18 Translocation in Cutaneous Lymphomas and Pseudolymphomas

Cerroni, Lorenzo; Volkenandt, Matthias; Rieger, E.; Soyer, H. P.; Kerl, Helmut

doi:10.1111/1523-1747.ep12371768

Cited by 179 publications

(86 citation statements)

References 19 publications

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“…18 MALT lymphomas and primary CBCLs also share multiphasic histologic features, with the various cell types often grouped together rather than intermingled; lymphoepithelial lesions, although this is an occasional finding in primary CBCL; phenotype of neoplastic B cells (CD5-, CD10-); and genotype of neoplastic B cells, which do not show either t(11; 14)/t(14; 18) translocation or bcl-1/bcl-2 gene and c-myc oncogene rearrangements. 23,24,38,39 Bcl-2 expression is never detected in B-cell pseudolymphomas 38 and is significantly more frequent in secondary CBCL (nodal FCC lymphomas with secondary cutaneous involvement) than in primary CBCL38,39; in addition, the relation between bcl-2 expression and bcl-2 gene rearrangement is definitely closer in secondary CBCL than in primary CBCL. 38,39 These findings suggest the possible significance of bcl-2 protein expression and bcl-2 genes rearrangement to differentiate between B-cell pseudolymphomas, primary CBCL, and secondary CBCL.…”

Section: An Alternative View: the Salt/malt Hypothesismentioning

confidence: 99%

Primary cutaneous B-cell lymphoma: A clinically homogeneous entity?

Pimpinelli

Santucci²,

Mori³

et al. 1997

Journal of the American Academy of Dermatology

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Section: An Alternative View: the Salt/malt Hypothesismentioning

confidence: 99%

Primary cutaneous B-cell lymphoma: A clinically homogeneous entity?

Pimpinelli

Santucci²,

Mori³

et al. 1997

Journal of the American Academy of Dermatology

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“…2 In the WHO classification, primary cutaneous FL is denoted as an FL variant, although this entity generally lacks the characteristic t(14;18)(q32;q21). 1,3 Surprisingly, primary gastrointestinal FL, which clearly stands out in having a characteristic clinical behavior, harboring the t(14;18) involving IgH/BCL-2 and with specific immunophenotypic features, is not considered as a separate entity in this classification. 1,[4][5][6] The cytological and architectural features of FL are highly reminiscent of those of normal germinal centers (GC).…”

Section: Introductionmentioning

confidence: 99%

Molecular pathways in follicular lymphoma

2006

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Follicular lymphoma (FL) is one of the most common B-cell non-Hodgkin's lymphomas. The initiating genetic event found in B90% of FL is the t(14;18), causing constitutive expression of the antiapoptotic BCL-2 protein. The exact secondary alterations leading to full FL development are still poorly defined. In this review, we address (i) the genetic pathways associated with tumorigenesis and progression of FL, (ii) the role of micro-environmental factors with emphasis on B-cell receptor ligands and (iii) lymphoma models in mice and what they teach us about lymphomagenesis in man.

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“…This difference in survival probability and treatment underscores the importance of finding molecular or immunophenotypic markers that can distinguish between these two different clinical presentations of FL. Although pCFLs display the same morphology and CD10 or bcl6 expression as nodal FL, they may differ in the incidence of t(14;18), which has only rarely been reported in pCFL (4,12,24,31). Thus, in our series, t(14;18) was present in three of three cases analyzed, in contrast with its absence in 10 of 10 of the cases of pCFL included here for comparison.…”

Section: Discussionmentioning

confidence: 56%

Cutaneous Presentation of Follicular Lymphomas

et al. 2001

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The description of primary cutaneous follicular lymphoma has raised interest in the differential diagnosis of this versus disseminated follicular lymphoma involving the skin. We report here on four cases of Stage IV follicular lymphoma, diagnosed in skin biopsy, in which cutaneous lesion was the most noticeable feature of clinical presentation. In all cases, the morphological features were superimposed over typical nodal follicular lymphoma. Apart from classic B-cell markers, they were characterized by CD10 and bcl6 positivity, markers of follicle germinal center cells; and bcl2 expression, with a corresponding t(14;18) translocation in three of three cases examined. In all four cases, bone marrow study and clinical staging revealed disease that had disseminated since diagnosis. Follow-up showed relapsing cutaneous and nodal disease in two cases. The only difference observed with a control group of 10 cases of primary cutaneous follicular lymphoma was the absence in this group of t(14; 18). Disseminated classical follicular lymphoma has to be considered in the differential diagnosis of follicular lymphoma presenting in the skin. This series of cases suggests that the presence of t(14;18) could imply the existence of disease that has disseminated beyond the skin and that cases harboring this translocation could be candidates for systemic polychemotherapy.

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bcl-2 Protein Expression and Correlation with the Interchromosomal 14;18 Translocation in Cutaneous Lymphomas and Pseudolymphomas

Cited by 179 publications

References 19 publications

Primary cutaneous B-cell lymphoma: A clinically homogeneous entity?

Primary cutaneous B-cell lymphoma: A clinically homogeneous entity?

Molecular pathways in follicular lymphoma

Cutaneous Presentation of Follicular Lymphomas

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