2019
DOI: 10.1093/cercor/bhz081
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BDNF Controls Bidirectional Endocannabinoid Plasticity at Corticostriatal Synapses

Abstract: The dorsal striatum exhibits bidirectional corticostriatal synaptic plasticity, NMDAR and endocannabinoids (eCB) mediated, necessary for the encoding of procedural learning. Therefore, characterizing factors controlling corticostriatal plasticity is of crucial importance. Brain-derived neurotrophic factor (BDNF) and its receptor, the tropomyosine receptor kinase-B (TrkB), shape striatal functions, and their dysfunction deeply affects basal ganglia. BDNF/TrkB signaling controls NMDAR plasticity in various brain… Show more

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Cited by 24 publications
(19 citation statements)
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References 106 publications
(199 reference statements)
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“…Within the NAc, eCBs are synthesized and released from MSNs following activation of either D1 ( Shonesy et al, 2020 ) or D2 ( Lerner and Kreitzer, 2012 ) receptors. Also noteworthy is recent evidence suggesting that tyrosine receptor kinase B activation augments intracellular calcium transients to promote eCB synthesis and spike-timing dependent plasticity in the striatum ( Gangarossa et al, 2020 ). Upon release from MSNs, the eCBs then travel retrogradely before acting upon CB1s located on FSIs within the NAc ( Mateo et al, 2017 ; Wright et al, 2017 ).…”
Section: Introductionmentioning
confidence: 99%
“…Within the NAc, eCBs are synthesized and released from MSNs following activation of either D1 ( Shonesy et al, 2020 ) or D2 ( Lerner and Kreitzer, 2012 ) receptors. Also noteworthy is recent evidence suggesting that tyrosine receptor kinase B activation augments intracellular calcium transients to promote eCB synthesis and spike-timing dependent plasticity in the striatum ( Gangarossa et al, 2020 ). Upon release from MSNs, the eCBs then travel retrogradely before acting upon CB1s located on FSIs within the NAc ( Mateo et al, 2017 ; Wright et al, 2017 ).…”
Section: Introductionmentioning
confidence: 99%
“…(A,B) Homosynaptic eCB-LTP in the striatum (A) and hippocampus (B) . (A) eCB-LTP is induced by few spike-timing-dependent plasticity (STDP) pairings (~10–15 post-pre pairings), whereas eCB-LTD is induced by a larger number of pairings (~50–100 pre-post pairings) at the same corticostriatal synapses (Cui et al, 2015 , 2016 , 2018a ; Xu et al, 2018 ; Gangarossa et al, 2020 ). Right: top panel illustrates the domains of expression of eCB-LTP, eCB-LTD, and NMDAR-LTP related to the polarity and number of STDP pairings.…”
Section: Ecb-mediated Synaptic Potentiationmentioning
confidence: 99%
“…In the neocortex, eCBs released by dendritic calcium spikes reduce inhibitory transmission, which facilitates postsynaptic calcium spike generation, the calcium-dependent release of BDNF, and ultimately the induction of eCB-LTP (Maglio et al, 2018 ). For homosynaptic eCB-LTP, TrkB activation facilitates 2-AG synthesis and shapes the expression domain of corticostriatal eCB-LTP (Gangarossa et al, 2020 ).…”
Section: Neuromodulation Of Ecb-ltpmentioning
confidence: 99%
“…Interestingly, LTP magnitude is not affected by adding more pairings, suggesting a potentially rapid memory acquisition through the induction of an abrupt all-or-none LTP in response to minimal stimulation, as observed at CA3-CA1 synapses (Petersen et al, 1998). Moreover, in striatal projecting neurons and in L5 pyramidal cells of the somatosensory cortex, in vitro STDP paradigms involving ∼5-15 cortico-striatal pairings induce an endocannabinoid-mediated LTP (eCB-LTP; Cui et al, 2015Cui et al, , 2016Cui et al, , 2018aXu et al, 2018;Gangarossa et al, 2020; Figure 1G). This LTP disappears for 25-50 pairings, only to re-emerge at 75 pairings as an NMDAR-mediated LTP (NMDAR-LTP).…”
Section: Sparse Firingmentioning
confidence: 99%