BDNF serum concentrations in first psychotic episode drug-naïve schizophrenic patients: Associations with personality and BDNF Val66Met polymorphism

Sotiropoulou, Marianthi; Mantas, Christos; Bozidis, Petros; Marselos, Marios; Mavreas, Venetsanos; Hyphantis, Thomas; Αντωνίου, Κατερίνα

doi:10.1016/j.lfs.2013.01.008

Cited by 35 publications

(26 citation statements)

References 49 publications

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“…It has been shown that BDNF knockout mice exhibit elevated conspecific aggression and social dominance [39]. Schizophrenic patients with first-episode psychosis have lower serum concentrations of the BDNF and score higher on the Aggression-Hostility scale than healthy individuals [40]. Winning animals have significantly more Bdnf mRNA in the dentate gyrus of the dorsal hippocampus than losing animals and home cage controls [41].…”

Section: Discussionmentioning

confidence: 99%

Reduction of serotonergic gene expression in the raphe nuclei of the midbrain under positive fighting experience in male mice

Smagin¹,

Boyarskikh²,

Bondar³

et al. 2013

ABB

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Section: Discussionmentioning

confidence: 99%

Reduction of serotonergic gene expression in the raphe nuclei of the midbrain under positive fighting experience in male mice

Smagin¹,

Boyarskikh²,

Bondar³

et al. 2013

ABB

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“…Moreover, non addicted patients in their first psychotic episode, scored higher in neuroticism than healthy participants [44], [45].…”

Section: Introductionmentioning

confidence: 87%

Neuroticism Associated with Cocaine-Induced Psychosis in Cocaine-Dependent Patients: A Cross-Sectional Observational Study

et al. 2014

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BackgroundCocaine consumption can induce transient psychotic symptoms, which has been correlated with more severe addiction and aggressive behavior. However, little is known about the nature of the relationship between personality traits and psychotic symptoms in cocaine-dependent patients. This study examined the relationship between neuroticism and cocaine-induced psychosis.MethodsA total of 231 cocaine-dependent patients seeking treatment were recruited to the study. Personality was evaluated by the Zuckerman-Kuhlman Personality Questionnaire. Cocaine-induced psychosis questionnaire, SCID-I, and SCID-II were used to evaluate comorbidity and clinical characteristics. Data analysis was performed in three steps: descriptive, bivariate, and multivariate analyses.ResultsCocaine-induced psychosis was reported in 65.4% of the patients and some personality disorder in 46.8%. Two personality dimensions (Neuroticism-Anxiety and Aggression-Hostility) presented a significant effect on the risk of experiencing psychotic symptoms (t(229) = 2.69, p = 0.008; t(229) = 2.06, p = 0.004), and patients with psychotic symptoms showed higher scores in both variables. On the multivariate analysis, only Neuroticism remained as a significant personality factor independently associated with psychotic symptoms (Wald = 7.44, p<0.05, OR = 1.08, CI 95% 1.02–1.16) after controlling for age, gender and number of consumption substances.ConclusionsAn association between high neuroticism scores and presence of psychotic symptoms induced by cocaine has been found, independently of other consumption variables. Personality dimensions should be evaluated in cocaine-dependent patients in order to detect high scores of neuroticism and warn patients about the risk of developing cocaine-induced psychotic symptoms.

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“…13,20 The BDNF level was lower in patients with first-episode schizophrenia who did not receive treatment. 21,22 According to another study, the BDNF levels in untreated schizophrenia patients were similar to the BDNF levels in the control group. 23 The BDNF levels were lower in certain subtypes of FEP (cognitive impairment, history of childhood trauma).…”

Section: Discussionmentioning

confidence: 86%

Lower Brain-Derived Neurotropic Factor Levels in Untreated Adolescents With First-Episode Psychosis

Şimşek¹,

Gençoğlan²,

Yüksel³

et al. 2015

Journal of Clinical Psychopharmacology

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BDNF serum concentrations in first psychotic episode drug-naïve schizophrenic patients: Associations with personality and BDNF Val66Met polymorphism

Cited by 35 publications

References 49 publications

Reduction of serotonergic gene expression in the raphe nuclei of the midbrain under positive fighting experience in male mice

Reduction of serotonergic gene expression in the raphe nuclei of the midbrain under positive fighting experience in male mice

Neuroticism Associated with Cocaine-Induced Psychosis in Cocaine-Dependent Patients: A Cross-Sectional Observational Study

Lower Brain-Derived Neurotropic Factor Levels in Untreated Adolescents With First-Episode Psychosis

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