BDNF Val66Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy

Peters, Renata B; Xavier, Janaína Reis; Mondin, Thaíse Campos; Cardoso, Taiane; Ferreira, Fabiana B; Teixeira, Liana; Gräeff, Kiane; Quevedo, Luciana de Ávila; Jansen, Karen; Souza, Luciano Dias de Mattos; Oses, Jean Pierre; Pinheiro, Ricardo Tavares; Silva, Ricardo A. da; Ghisleni, Gabriele

doi:10.1590/1516-4446-2019-0726

Cited by 21 publications

(16 citation statements)

References 39 publications

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“…The second most frequently investigated gene was Brain-Derived Neurotrophic Factor ( BDNF) ( n = 5). All five of the studies reviewed investigated SNP rs6265 in exon 11 of the BDNF gene ( 105 , 116 , 122 , 129 , 131 ). Of the four studies, three found Val/Val homozygous genotype to be associated with resilience, while two studies found the Met allele to be associated with resilience.…”

Section: Resultsmentioning

confidence: 99%

Genetic Variants Associated With Resilience in Human and Animal Studies

2022

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Resilience is broadly defined as the ability to maintain or regain functioning in the face of adversity and is influenced by both environmental and genetic factors. The identification of specific genetic factors and their biological pathways underpinning resilient functioning can help in the identification of common key factors, but heterogeneities in the operationalisation of resilience have hampered advances. We conducted a systematic review of genetic variants associated with resilience to enable the identification of general resilience mechanisms. We adopted broad inclusion criteria for the definition of resilience to capture both human and animal model studies, which use a wide range of resilience definitions and measure very different outcomes. Analyzing 158 studies, we found 71 candidate genes associated with resilience. OPRM1 (Opioid receptor mu 1), NPY (neuropeptide Y), CACNA1C (calcium voltage-gated channel subunit alpha1 C), DCC (deleted in colorectal carcinoma), and FKBP5 (FKBP prolyl isomerase 5) had both animal and human variants associated with resilience, supporting the idea of shared biological pathways. Further, for OPRM1, OXTR (oxytocin receptor), CRHR1 (corticotropin-releasing hormone receptor 1), COMT (catechol-O-methyltransferase), BDNF (brain-derived neurotrophic factor), APOE (apolipoprotein E), and SLC6A4 (solute carrier family 6 member 4), the same allele was associated with resilience across divergent resilience definitions, which suggests these genes may therefore provide a starting point for further research examining commonality in resilience pathways.

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Section: Resultsmentioning

confidence: 99%

Genetic Variants Associated With Resilience in Human and Animal Studies

2022

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“…When observing only the BDNF Val66Met (rs6265) genetic variant frequency and genotypic distribution (Table 1), the GG (Val/Val) genotype was frequent in more than 50% of the MDD sample studied in 65% of the analyzed studies [17,18,19,21,23,25,26,[30][31][32][33] (Figure 3). Its frequency is lower in only few studies [16,20,22,[27][28][29].…”

Section: Bdnf Gg (Val/val) Genotype Frequency In Differentmentioning

confidence: 99%

“…In addition to pharmacological treatments and transcranial stimulation focused on MDD, cognitive therapies are indicated to patients with MDD to help with resilience-known as an individual's ability to deal with stress or trauma, for example [18]. Regarding BDNF Val66Met (rs6265) polymorphism, Peters et al [18] noted that participants with an A (Met) allele presented higher resilience scores compared to those of the GG (Val/Val) genotype (p = 0:037). Furthermore, cognitive therapy improved resilience (p = 0:001) and reduced depressive effects (p = 0:001), depending on their sex (p = 0:008) and genetic susceptibility (p = 0:048) [18].…”

Section: Bdnf Genetic Variant and Treatment Responsementioning

confidence: 99%

“…Regarding BDNF Val66Met (rs6265) polymorphism, Peters et al [18] noted that participants with an A (Met) allele presented higher resilience scores compared to those of the GG (Val/Val) genotype (p = 0:037). Furthermore, cognitive therapy improved resilience (p = 0:001) and reduced depressive effects (p = 0:001), depending on their sex (p = 0:008) and genetic susceptibility (p = 0:048) [18].…”

Section: Bdnf Genetic Variant and Treatment Responsementioning

confidence: 99%

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BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder

Siqueira

Gontijo

Santos

et al. 2021

Behavioural Neurology

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Major depressive disorder (MDD) still has an unknown etiology and mechanisms. Many studies have been conducted seeking to associate and understand the connection of different genetic variants to this disease. Researchers have extensively studied the brain-derived neurotrophic factor (BDNF) Val66Met genetic variant in MDD; yet, their findings remain inconsistent. This systematic review sought to verify the GG (Val/Val) genotype frequency fluctuation in different populations with MDD. For this, we searched in different databases and, after applying the eligibility criteria, selected 17 articles. Most studies demonstrate the higher frequency of the ancestral (wild) GG (Val/Val) genotype, although associations of the polymorphic A (Met) allele, changes in BDNF protein serum levels, or both were also found in MDD, whether related to the disease’s development or other factors. Nevertheless, despite these findings, disagreements between several studies are seen. For this reason, further BDNF Val66Met genetic variant studies should not only bridge the gap in the knowledge of this polymorphism’s role in MDD’s different facets but also analyze the genotypic and phenotypic heterogeneity in different populations to help provide a better quality of life for patients.

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“…A prior study demonstrated a positive correlation between BDNF levels and the function of the central nervous system and peripheral nervous system [8]. Moreover, BDNF, expressed in the brain, is involved in the development of mental disorders, and studies show that peripheral BDNF can potentially be used as a marker of these diseases in humans [9]. Previously, we demonstrated that autoimmune thyroiditis (AIT) and hypothyroidism could affect the transcription of the genes involved in neurogenesis, nerve impulse transmission, and cell cycle regulation [10], [11], 12], [13], [14].…”

Section: Introductionmentioning

confidence: 98%

Association between Serum Brain-derived Neurotrophic Factor and 25-OH Vitamin D Levels with Vitamin D Receptors Gene Polymorphism (rs2228570) in Patients with Autoimmune Thyroiditis and Hypothyroidism

Kamyshna

Pavlovych

Kamyshnyі

2021

Open Access Maced J Med Sci

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BACKGROUND: Different polymorphisms in Vitamin D receptors (VDRs) have an important role in autoimmune thyroiditis (AIT) risk. Hashimoto’s thyroiditis (HT) is the most recurrent autoimmune thyroid disorder. Patients with HT may suffer from cognitive impairment brain-derived neurotrophic factor (BDNF) which has been identified as an important growth factor that is involved in learning and memory. AIM: This study examined the linkage of VDR gene polymorphism (rs2228570) with blood serum levels of BDNF and 25-OH Vitamin D in thyroid pathology of patients in the West Ukrainian population. METHODS: This research is a case–control study was performed in HSEEU “Bukovinian State Medical University,” Chernivtsi Regional Endocrinology Center, and I. Horbachevsky Ternopil National Medical University, Ukraine, from September 2017 to December 2020. The study involved a total of 153 patients with post-operative hypothyroidism, hypothyroidism induced by AIT, and patients with both AIT and elevated serum antibodies anti-thyroglobulin (anti-Tg) and anti-thyroid peroxidase. BDNF levels in the sera of the patients and healthy individuals were quantified using enzyme-linked immunosorbent assay (ELISA) with highly sensitive Human BDNF ELISA Kit. Genotyping of the VDR (rs2228570) gene polymorphism using TaqMan probes and TaqMan Genotyping Master Mix (4371355) on CFX96™ Real-Time Polymerase Chain Reaction (PCR) Detection System (Bio-Rad Laboratories, Inc., USA). PCR for TaqMan genotyping was carried out according to the kit instructions (Applied Biosystems, USA). RESULTS: Our study revealed a significant decrease in the BDNF level in the study group in carriers of the AA and AG genotypes by 1.58 and 2.39 times, corresponding, compared with carriers of the AA genotype in the control group. Concurrently, there was no significant difference in the BDNF level between different genotypes of VDR rs2228570 in the research group. In our study, analysis of the correlation between serum BDNF levels and 25-OH Vitamin D concentration shows a moderate direct relationship (r = 0.4) between BDNF and 25-OH Vitamin D (p = 0.006). CONCLUSIONS: The rs2228570 VDR polymorphism is not a risk factor for decreased serum BDNF levels. At the same time, our study found a moderate direct relationship between serum BDNF levels and 25-OH Vitamin D.

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BDNF Val66Met polymorphism and resilience in major depressive disorder: the impact of cognitive psychotherapy

Cited by 21 publications

References 39 publications

Genetic Variants Associated With Resilience in Human and Animal Studies

Genetic Variants Associated With Resilience in Human and Animal Studies

BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder

Association between Serum Brain-derived Neurotrophic Factor and 25-OH Vitamin D Levels with Vitamin D Receptors Gene Polymorphism (rs2228570) in Patients with Autoimmune Thyroiditis and Hypothyroidism

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