BE-31405, a New Antifungal Antibiotic Produced by Penicillium minioluteum. I. Description of Producing Organism, Fermentation, Isolation, Physico-chemical and Biological Properties.

Antifungal substances produced by Penicillium oxalicum strain PY-1—potential antibiotics against plant pathogenic fungi

“…As far as we are aware this is the first report of P. oxalicum producing an antifungal substance containing least two active compounds. Fungi of the genus Penicillium are important producers of antibacterial compounds, but only a few are reported to produce antifungal substances (Kumagai et al 1990;Matsukuma et al 1992;Jackson et al 1993;Okada et al 1998;Nose et al 2000;Sasaki et al 2000;Kaiserer et al 2003;He et al 2004;Nicoletti et al 2004). HPLC separation results showed that strain PY-1 produced at least two active compounds which may significantly inhibit mycelial growth of many pathogenic fungi and suppress infection by S. sclerotiorum when aerially applied.…”

Pharmacology, in vitro activity, and in vivo efficacy of new antifungal agents

“…However, signifi cant in vivo activity has not been observed with sordarin because of unfavorable pharmacokinetic characteristics (short half-life and low concentrations) and limited in vitro activity against pathogenic fungi [68]. To overcome these issues, several synthetic sordarin derivatives have been synthesized with modifi cations to the chemical structure that have increased in vitro potency and more favorable pharmacokinetic characteristics in vivo [68][69][70]. One of these is FR290581 (Astellas Pharma, Inc., Osaka, Japan) ( Table 1 and Fig.…”

Isolation of Microbial Natural Products

“…In the case of ionizable functional groups existing in the solute molecules, solutions of weak acids or bases can be utilized in order to ensure conversion to the ionized species which then allows rapid elution owing to the repulsive interactions with the support. Examples of isolations where synthetic resins have been utilized in the isolation process and the solvents used to effect elution from the resins are shown for BE-31405 ( 27 ) , calphostin D ( 28 ) , tubelactomicin A ( 29 ) , DC-52 and the artifact derived from it DX-52-1 ( 30, 31 ) , teicoplanin A 2 -2 ( 32 ) , and pentostatin ( 33 ) in Table 5 .…”