Concerning the problem of lubrication failure of high speed rotor bearings, a unified model of mixed lubrication is built for angular contact ball bearings with comprehensive consideration of the effects of contact geometry, real rough surface topography, elastic deformation, rheological properties of lubricants, high speed spinning properties of balls, and other factors. On this basis, the effect laws of rotate speed, load, vacuum, high and low temperature, and other working and environmental conditions on the contact and lubrication properties of the microscopic transmission interface of a bearing are analyzed, laying a theoretical basis for the application of high speed rotor bearings in a multi-stress space environment.