Becker’s Melanosis: an Ultrastructural Study

Bhawan, Jag; Chang, Wallace H. J.

doi:10.1159/000250598

Cited by 20 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…13). Multiple layers of basement membrane have been reported in diabetes (Vracko & Benditt 1974) and many diverse situations (Bhawan & Chang 1979, Gshnait et al 1975, Cooper & Goodman 1974, Bhawan et al 1979b including normal tissues (Friederici etal. 1966,Parakkal 1966.…”

Section: Stromal Changesmentioning

confidence: 99%

Cellular Blue Nevus

1980

Self Cite

View full text Add to dashboard Cite

Cellular blue nevus can be clinically and histogenetically confused with malignant melanoma but remains a benign neoplasm of uncertain histogenesis. This paper reports the ultrastructural features of three cases of cellular blue nevus and emphasizes melanosomal alterations, including immature and granular forms, multiple layers of basement membrane around vessels, nerve fibers and tumor cells; endothelial fenestrations and banded structures within the nerve and outside in the stroma. A unifying concept of neural crest derived tumors is presented to better understand the histogenesis of cellular blue nevus.

show abstract

Section: Stromal Changesmentioning

confidence: 99%

Cellular Blue Nevus

1980

Self Cite

View full text Add to dashboard Cite

show abstract

“…Knowledge of the histopathologic and immunohistochemical characteristics in BN skin may be important not only for diagnosis but also to differentiate it from other pigmented disorders. There are many case reports of BN but only a few systematic studies on the histopathologic characteristics of BN 7–10 . Moreover, there has been no report of AR immunohistochemistry in BN patients.…”

mentioning

confidence: 99%

Androgen receptor overexpression in Becker nevus: histopathologic and immunohistochemical analysis

Kim¹,

Han

Kang³

et al. 2008

J Cutan Pathol

View full text Add to dashboard Cite

Journal of Cutaneous PathologyAndrogen receptor overexpression in Becker nevus: histopathologic and immunohistochemical analysis Background: Becker nevus (BN) is a unilateral, hairy, pigmented cutaneous hamartoma that frequently appears in adolescence. Several features of BN suggest that increased androgen sensitivity plays a role in its pathogenesis. There have been only a few studies of histopathologic and immunohistochemical characteristics of BN, and the etiopathogenesis has not been fully established. Methods: Two-millimeter punch biopsies were taken from lesional and perilesional normal skin of 30 patients diagnosed as having BN. Fifteen skin samples each of lentigo and café au lait spots were used as controls. The sections were stained with hematoxylin-eosin, FontanaMasson, antibodies to NKI/beteb, MART-1 (Melanoma Antigen Recognized by T cells), S-100 protein and androgen receptor (AR). Results: Histopathologic features of BN showed frequent acanthosis, papillomatosis, keratotic plugging, irregular rete ridge elongation and flattening in the epidermis. Especially, the shape of the rete ridges in BN had a relatively characteristic appearance, which was the fusion of more than two adjacent rete ridges. Melanocyte counts were significantly increased in BN skin. The extent of AR expression was significantly higher in the epidermis of BN. Conclusions: Our study indicates that there may be an association between AR and BN, but additional studies will be required to evaluate this further.Kim YJ, Han JH, Kang HY, Lee E-S, Kim YC. Androgen receptor overexpression in Becker nevus: histopathologic and immunohistochemical analysis.

show abstract

“…However, during photocheniotherapy using 8methoxypsoralen, Zaynoun et al, (1977a) did not observe similar changes in pigment cells and granules and it also appears in other instances that the size of melanosomes is probably not the sole determining factor in aggregation; so in preeaneerous melanosis (Hutchinson's freckles), the melanosomes have an average size of 0,165 ± 0,010 X 0.387 ± 0,024/Um and are not aggregated in phagolysosomes (Anton-Lamprecht et al 1971), In the pigmented marks of Albright's syndrome, the melanosomes of small size also remain unexpectedly dispersed in the keratinocytes (Frenk 1971). The same phenomenon occurs in the lentigines in Leopard syndrome (Bhawan et al 1976), in nevus spilus (Takahaslu 1976), in the hypermelanotic state of Becker's melanosis (Bhawan & Chang 1979) and in the hyperpigmentation following treatment of brain tumors (Gauthier et al, 1976). Also, in phototoxic pigmentary responses induced by psoralens, an increase in melanosomal size without a consistent increase in the percentage of single melanosomes was observed by Zaynoun et al, (1977b), If there is a striking tendency for small melanosomes to be aggregated, in white skin there is no definite relationship between the intensity of pigmentation and the distribution pattern of melanosomes (Konrad & Wolff 1973), Even if the size of melanosomes mainly influences their distribution • \ Fig.…”

Section: Discussionmentioning

confidence: 93%

Ultrastructure of Early Pigmentary Changes in Dowling‐Degos' Disease^*

et al. 1980

View full text Add to dashboard Cite

Dowling-Degos' anomaly is characterized by a reticular and spotted pigmentation of the skin folds; this pigmentary disturbance, occurring most often in women, is a dominant inherited genodermatosis which worsens progressively and may exhibit in the early phase rapid changes in severity after emotional stress. In a 9-year-old girl, an electonmicroscopic study of pigmented lesions showed a strong melanocytic activity with quantitative increase of the melanosomes; the average size of the melanosomes was not different when compared to normal Caucasoid skin, but in the keratinocytes they were distributed according to a dispersed pattern as in black skin. The pigmentary state of Dowling-Degos' disease is another example of melanocyte-keratinocyte interaction where the epidermal melanin pattern and the size of pigment granules are not in striking correlation. An accelerated rate of melanogenesis and pigmentation may be another factor determining a non-aggregated distribution of the melanosomes within the keratinocytes. The nature of the stimulus of pigmentation in these skin areas which are not sun-exposed is still unclear.

show abstract

Becker’s Melanosis: an Ultrastructural Study

Cited by 20 publications

References 13 publications

Cellular Blue Nevus

Cellular Blue Nevus

Androgen receptor overexpression in Becker nevus: histopathologic and immunohistochemical analysis

Ultrastructure of Early Pigmentary Changes in Dowling‐Degos' Disease^*

Contact Info

Product

Resources

About

Becker’s Melanosis: an Ultrastructural Study

Cited by 20 publications

References 13 publications

Cellular Blue Nevus

Cellular Blue Nevus

Androgen receptor overexpression in Becker nevus: histopathologic and immunohistochemical analysis

Ultrastructure of Early Pigmentary Changes in Dowling‐Degos' Disease*

Contact Info

Product

Resources

About

Ultrastructure of Early Pigmentary Changes in Dowling‐Degos' Disease^*