2020
DOI: 10.20944/preprints202003.0395.v1
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Beclabuvir can Inhibit the RNA-dependent RNA Polymerase of Newly Emerged Novel Coronavirus (SARS-CoV-2)

Abstract: Recent emergence of novel coronavirus (SARS-CoV-2) in Wuhan, China has resulted more than 14,510 global deaths. To date well-established therapeutics modules for infected patients are unknown. In this present initiative, molecular interactions between well-known antiviral drugs against the Hepatitis-C virus (HCV) have been investigated theoretically against the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. HCV and SARS-CoV-2 are both +ssRNA viruses. At 25o C beclabuvir, a non-nucleoside inhibitor of the R… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
15
0

Year Published

2020
2020
2023
2023

Publication Types

Select...
5
1
1

Relationship

2
5

Authors

Journals

citations
Cited by 10 publications
(17 citation statements)
references
References 21 publications
2
15
0
Order By: Relevance
“…For example, signs and symptoms [38], mode of transmission [39], WHO-solidarity trials [40], contact tracing by mobiles apps such as "Arogya Setu" by India [41], CRISPR-Cas based rapid diagnostic of SARS-CoV-2 [42], and also monitoring daily cases by crowd-sourcing from https://www.covid19india.org/. Moreover, several reports are coming out as preprints and formal peer-review publications about repurposing known drugs [2] and antiviral drugs against the SARS-CoV-2 [43]. Reports suggesting possible anti-COVID-19 effects of different phytochemicals by in silico screening methods [4].…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…For example, signs and symptoms [38], mode of transmission [39], WHO-solidarity trials [40], contact tracing by mobiles apps such as "Arogya Setu" by India [41], CRISPR-Cas based rapid diagnostic of SARS-CoV-2 [42], and also monitoring daily cases by crowd-sourcing from https://www.covid19india.org/. Moreover, several reports are coming out as preprints and formal peer-review publications about repurposing known drugs [2] and antiviral drugs against the SARS-CoV-2 [43]. Reports suggesting possible anti-COVID-19 effects of different phytochemicals by in silico screening methods [4].…”
Section: Resultsmentioning
confidence: 99%
“…2 Motif, 3 Align, 4 [58], mouse β-defensin-4 by Zhao et al [59], PCSK target motif by Cheng et al [60], HR2 by Xia et al [61,62], HR2 by Zhu et al [63], heptad repeats 1 and 2 (HR1 and HR2) in the S protein by [64].…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Elfiky (2020) used sequence analysis, modeling and docking, identifying sofosbuvir, IDX-184, ribavirin, and remdesivir as potential therapies [ 100 ]. Beclabuvir, an HCV RdRp inhibitor, has also been predicted to bind SARS-CoV-2 RdRp [ 101 ].…”
Section: The Importance Of Multitargets To Cadd Approaches: Pl mentioning
confidence: 99%
“…It is typically done by a nasopharyngeal swab, and the results can be obtained within a few hours to two days. Automated assay from Abbott Diagnostics uses an isothermal nucleic acid amplification method [3]. Serology methods are in the stage of development [4].…”
Section: Introductionmentioning
confidence: 99%