Beclin 1 expression predicts favorable clinical outcome in patients with diffuse large B-cell lymphoma treated with R-CHOP

Huang, Jia Jia; Zhu, Ying; Lin, Tong; Jiang, Wen Qi; Huang, Hui Qiang; Li, Zhi Ming

doi:10.1016/j.humpath.2010.12.014

Cited by 44 publications

(39 citation statements)

References 49 publications

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“…It appeared likely that Bcl-2 inhibited beclin 1-dependent autophagy. This finding is consistent with those of previous studies on solid tumors, which have shown that Bcl-2 negatively regulates beclin 1-dependent autophagic cell death (9,23,32). Accordingly, it could be assumed that Bcl-2 may be an oncogene that not only inhibits apoptosis but also blocks autophagy (33).…”

Section: Discussionsupporting

confidence: 93%

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Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis

Jiang

Huang

Zhang

et al. 2014

Braz J Med Biol Res

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Beclin 1 plays a critical role in autophagy and functions as a haploinsufficient tumor suppressor. The expression and prognostic significance of beclin 1 in head and neck adenoid cystic carcinoma (ACC) are largely unexplored. Therefore, we investigated the expression of beclin 1, Bcl-2, and p53 in head and neck ACC tissue. Tissue samples from 35 cases (15 females, 20 males) of head and neck ACC were utilized for immunohistochemistry. Beclin 1 expression was observed in 32 cases (91.4%) and considered to be high in 15 cases (42.9%) and low in 20 cases (57.1%). Beclin 1 expression was significantly correlated with a histological growth pattern (P=0.046) and histological grade (P=0.037). Beclin 1 expression was inversely correlated with Bcl-2 expression (P=0.013) and significantly associated with overall survival (P=0.006). Bcl-2 and p53 expression were observed in 21 cases (60.0%) and 16 cases (45.7%). Bcl-2 expression was significantly correlated with perineural invasion (P=0.041) and not associated with overall survival (P=0.053). p53 expression was directly correlated with beclin 1 expression (P=0.044). Our results indicated that beclin 1 may be a novel, promising prognostic factor for clinical outcome in head and neck ACC patients and may play a part in the development of head and neck ACC by interacting with Bcl-2 and p53.

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Section: Discussionsupporting

confidence: 93%

“…Scores for intensity and proportion were multiplied to give a total score. The staining pattern of the slides was defined as follows: 0 to 3 (low beclin 1 expression) and 4 to 7 (high beclin 1 expression) (23). Tumor cells were considered immunopositive for Bcl-2 and p53 when stained in 30% or more of the cells (22,24).…”

Section: Methodsmentioning

confidence: 99%

Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis

Jiang

Huang

Zhang

et al. 2014

Braz J Med Biol Res

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“…The positive prognostic correlation of autophagic markers in hematological malignancies has also recently been reported. Diffuse large B-cell lymphoma cases treated with the R-CHOP regimen revealed a positive correlation between higher BECLIN 1 expression and favorable clinical outcomes [18] . Increased BECLIN 1 and LC3 positivity is associated with better treatment response and superior survival outcome in non-Hodgkin lymphomas, including small lymphocytic, marginal zone, follicular, diffuse large B-cell and peripheral T-cell lymphomas [12] .…”

Section: Discussionmentioning

confidence: 98%

“…Only cytoplasmic LC3 and BECLIN 1 expression was analyzed. In the case of BECLIN 1, several studies report that this antigen exhibits either nuclear or cytoplasmic expression [18][19][20][21] . However, most of our cases showed cytoplasmic expression.…”

Section: Beclin 1 and Lc3 Expressionmentioning

confidence: 99%

Autophagic Markers BECLIN 1 and LC3 Are Associated with Prognosis of Multiple Myeloma

Jung¹,

Roh²,

Lee³

et al. 2015

Acta Haematol

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Background/Aims: Autophagy is crucial for the survival and function of plasma cells including protection from toxic misfolded immunoglobulin and proper energy metabolism. Multiple myeloma (MM) is an indolent but eventually fatal neoplasm of plasma cells. Autophagy may play a critical role in the survival of MM cells and their response to chemotherapeutic agents. In this study, we correlated the expression of autophagy-related proteins with the prognosis of MM. Methods: In this retrospective cohort study, we examined the expression of the autophagic markers BECLIN 1 and microtubule-associated protein light chain 3 (LC3) in 89 cases of MM biopsied from 2001 to 2004 at the Asan Medical Center. The association of the expression scores of these markers with clinical outcomes was assessed. Results: Patients with strong immunoreactivity to BECLIN 1 or LC3 had a significantly better overall survival (OS) than patients with negative to moderate immunoreactivity (p = 0.036 and 0.018, respectively). This was also true for disease-specific survival (DSS; p = 0.051 and 0.043, respectively). In addition, LC3 immunostaining remained an independent factor impacting OS (p = 0.028) and DSS (p = 0.020) after multivariate analysis. Conclusions: The results of this study suggest that higher immunoreactivity for autophagic markers in MM is associated with superior patient survival.

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“…18 Some markers such as beclin-1 were shown to be the predictors of favorable clinical outcome in patients treated with R-CHOP. 20 Fascin was shown to be a poor prognostic factor in certain epithelial tumors due to its role cell adhesion, cell motility and invasiveness. [21][22][23] However, in lymphoid malignancies, fascin expression was observed in the entities representing the two distinct ends of biological behavior spectrum.…”

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confidence: 99%

Does Fascin Expression in Diffuse Large B-Cell Lymphomas have a Clinical Impact in Patients Treated with Anthracyclin-Based Chemotherapy Plus Rituximab?

Köse¹,

Kayaselçuk²,

Beşen³

et al. 2013

UHOD

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Fascin is an actin-bundling protein that is expressed by dendritic cells of the lymphoid tissue. Fascin expression is also seen in the neoplastic cells of classical Hodgkin lymphomas, nearly half of the anaplastic lymphomas and in some diffuse large B-cell lymphomas. We aimed to investigate the clinical significance of fascin expression in CD20 positive diffuse large B-cell lymphomas (DLBCL) in patients treated with cyclophosphamide, doxorubicin, vincristine, and prednisolone plus rituximab (R-CHOP). Thirtyfour of the 55 patients included in the study showed fascin expression, 16 of them being diffuse and strong. There was no statistically significant correlation between fascin expression and overall survival and disease-free survival, sex, disease stage, chemotherapy response, whether or not having bulky disease, extranodal involvement, and international prognostic index (IPI) score. The study has failed to show prognostic significance of fascin expression in DLBCL patients treated with R-CHOP. However, because of the alterations in fascin expression in a variety of benign and malignant lymphoid entities, regardless of its prognostic impact, studies on fascin expression may help us to understand tumor biology of lymphomas better. Fascin, lenfoid dokunun dendritik hücreleri taraf›ndan eksprese edilen, aktin paketleyici bir proteindir. Klasik Hodgkin lenfomalar›n neoplastik hücrelerinin, anaplastik lenfomalar›n yaklafl›k yar›s›n›n ve diffüz büyük B-hücreli lenfomalar›n bir k›sm›n›n da fascin eksprese etti¤i gösterilmifltir. Bu çal›flman›n amac›, siklofosfamid, doksorubisin, vinkristin, prednizolon ile birlikte rituksimab (R-CHOP) tedavisi alan CD20 pozitif diffüz büyük B-hücreli lenfomal› (DBBHL) hastalarda fascin ekspresyonunun klinik önemi olup olmad›¤›n› ortaya koymakt›r. Çal›flmaya dahil edilen 55 hastaya ait tümör örneklerinin 34'ünde immünhistokimyasal yöntemle fascin pozitifli¤i saptand›. Otuzdört vakan›n 16's›ndaki pozitiflik yayg›n ve kuvvetli idi. ‹statistiksel de¤erlendirmede fascin ekspresyonu ile toplam yaflam süre-si, hastal›ks›z yaflam süresi, cinsiyet, hastal›¤›n evresi, kemoterapiye yan›t, bulky hastal›k olup olmamas›, ekstranodal tutulum ve enternasyonal prognostik indeks (IPI) skoru aras›nda anlaml› bir iliflki saptanmad›. Çal›flmada R-CHOP tedavisi alan DBBHL'l› hastalarda fascin ekspresyonun prognostik önemi oldu¤una dair bulgu saptanmam›flt›r. Farkl› benign ve malign lenfoid antitelerde fascin ekspresyonunda bildirilen de¤ifliklikler ve ayn› hastal›¤a sahip hastalarda saptanan ekspresyon farkl›l›klar›, prognostik önemi olmasa da, fascin üzerine yap›lacak çal›flmalar›n lenfomalar›n tümör biyolojisini daha iyi anlamam›za yard›mc› olaca¤›n› düflündürmektedir.

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Beclin 1 expression predicts favorable clinical outcome in patients with diffuse large B-cell lymphoma treated with R-CHOP

Cited by 44 publications

References 49 publications

Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis

Expression of beclin 1 in primary salivary adenoid cystic carcinoma and its relation to Bcl-2 and p53 and prognosis

Autophagic Markers BECLIN 1 and LC3 Are Associated with Prognosis of Multiple Myeloma

Does Fascin Expression in Diffuse Large B-Cell Lymphomas have a Clinical Impact in Patients Treated with Anthracyclin-Based Chemotherapy Plus Rituximab?

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