Beclomethasone dipropionate aerosol in childhood asthma

Dickson, W. E. Carnegie; Hall, Catherine; Ellis, Mary; Horrocks, Robert H.

doi:10.1136/adc.48.9.671

Cited by 42 publications

(10 citation statements)

References 6 publications

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“…These findings are comparable with those shown in children using a different inhaled steroid with high topical activity, beclomethasone dipropionate (Dickson et al, 1973;Morrow Brown and Storey, 1973).…”

supporting

confidence: 82%

Effect of placebo substitution during long-term betamethasone valerate aerosol treatment in asthmatic children.

Frears¹,

Hodgson²,

Friedman³

1975

Archives of Disease in Childhood

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(1975). Archives of Disease in Childhood, 50, 387. Effect of placebo substitution during long-term betamethasone valerate aerosol treatment in asthmatic children. Ten children with severe asthma, who had been well controlled on maintenance betamethasone valerate aerosol for an average of 11 months, were given placebo aerosols without their knowledge. The period of placebo substitution was compared with one 28-day period of betamethasone valerate therapy beforehand, and two 28-day periods afterwards.Symptoms were increased during the placebo period, and patients did not return to their previous well-controlled state until the second month after reinstitution of therapy. Changes in the means of twice-daily peak expiratory flow readings (PEFR) followed the same pattern as changes in symptoms. The exacerbation of asthma which occurred during placebo treatment was accompanied by a widening in the diurnal variation between morning and evening PEFR. In comparison with the previous period, morning PEFR fell by a greater amount than evening PEFR. Standardized running tests suggested an increase in exercise-induced bronchoconstriction and in the Exercise Lability Index when the child was receiving only placebo treatment as compared with betamethasone valerate treatment.The trial provided further evidence of the efficacy of betamethasone valerate aerosol in the prophylactic therapy of severe childhood asthma. As 2 of these children were able to discontinue long-term therapy it is unlikely that this drug causes dependency.Recent studies have shown the effectiveness of betamethasone valerate aerosol in the prophylactic therapy of severe childhood asthma (Frears, Wilson, and Friedman, 1973;McAllen, Kochanowski, and Shaw, 1974). These findings are comparable with those shown in children using a different inhaled steroid with high topical activity, beclomethasone dipropionate (Dickson et al., 1973;Morrow Brown and Storey, 1973).Follow-up of children using betamethasone valerate aerosol for longer than a year (Frears and Friedman, 1974) has shown that the initial dramatic clinical improvement experienced by most patients continues over some time and is then maintained.Many parents claim that with this therapy their children have been in better health than at any time

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supporting

confidence: 82%

Effect of placebo substitution during long-term betamethasone valerate aerosol treatment in asthmatic children.

Frears¹,

Hodgson²,

Friedman³

1975

Archives of Disease in Childhood

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“…Godfrey, Balfour-Lynn and Konig (1975) found that about 25% of their asthmatic children still required steroids in spite of being on Correspondence: Dr S. H. Ng, Consultant Paediatrician, Farnborough Hospital, Locksbottom, Kent. SCG. Long-term corticosteroids have unfortunately a constellation of unwanted side effects in the growing child, and the advent of inhaled metered aerosol preparations of corticosteroids having a high topical action relative to their systemic effect, such as beclomethasone dipropionate and betamethasone valerate, have been shown to be beneficial in the control of childhood asthma (Dickson et al, 1973;Frears, Wilson and Friedman, 1973;Howard and Jacoby, 1974). Bethamethasone valerate was noted by Kuzemko et al (1974) to be more effective than sodium cromoglycate when both were given twice daily.…”

Section: Introductionmentioning

confidence: 99%

Betamethasone valerate compared with sodium cromoglycate in asthmatic children

Ng¹,

Dash²,

Savage³

1977

Postgraduate Medical Journal

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“…However, the systemic effects of oral corticosteroids were soon observed in children, who developed central obesity and reduced growth velocity [1,2]. This led to the development of methods to deliver corticosteroids directly to the lungs by inhalation and the introduction of inhaled beclomethasone dipropionate in the early 1970s [3,4]. Drug delivery by inhalation proved to be advantageous as the systemic effects typically associated with oral corticosteroids were reduced to a minimum [5].…”

mentioning

confidence: 99%

Evaluating the effects of asthma therapy on childhood growth: principles of study design

Price¹,

Hindmarsh²,

Hughes³

et al. 2002

Eur Respir J

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Inhaled corticosteroids have been established as the most effective treatment for childhood asthma. However, concerns persist regarding their potential effects on growth and, most importantly, final height.To assess their effects on growth, inhaled corticosteroids can be compared with placebo (type 1 study), nonsteroidal anti-asthma therapy (type 2 study), another inhaled corticosteroid (type 3 study) or “real-life” anti-asthma therapy (type 4 study). Owing to the difficulties in obtaining final height data, several different surrogate measures have often been used: short-term lower leg growth, longer-term statural height growth velocity, childhood height and predicted final height.This paper discusses the choice of end point, key trial design issues (including selection and number of subjects in the active and control populations) duration of assessments and methods for measuring height and data analysis, in the context of the different study types.Specific study design recommendations have been developed after consideration of these factors, and these principles will be used to guide the interpretation of previously published growth studies.

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Beclomethasone dipropionate aerosol in childhood asthma

Cited by 42 publications

References 6 publications

Effect of placebo substitution during long-term betamethasone valerate aerosol treatment in asthmatic children.

Effect of placebo substitution during long-term betamethasone valerate aerosol treatment in asthmatic children.

Betamethasone valerate compared with sodium cromoglycate in asthmatic children

Evaluating the effects of asthma therapy on childhood growth: principles of study design

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