Beclomethasone dipropionate attenuates airways hyperresponsiveness to neurokinin A and histamine in asthma

Abstract

Airway responsiveness to histamine and NKA is reduced by BDP to the same extent. As a result of these findings, provocation with NKA is unlikely to provide additional useful information in the assessment of airway inflammation in asthma.

Diagnostic properties of the methacholine and mannitol bronchial challenge tests: A comparison study

“…We made efforts to reduce ICS effects by instructing to withhold ICS at least for 12 h prior to the test, but the potential effects of ICS may not have been fully excluded . Recent evidence suggests that ICS influences the outcomes of bronchial provocation tests …”

“…20,24,25 Recent evidence suggests that ICS influences the outcomes of bronchial provocation tests. 2,3,5,14,[17][18][19][20][21][22][23][24][25][26][27][28][29][30] In addition, low sensitivity could have been related to our defining criteria for asthma groups. We included the asthmatics by the combination of their physician diagnosis, recent symptoms and asthma medication, but not by the use of objective challenge tests.…”