Bee Venom Promotes Hair Growth in Association with Inhibiting 5α-Reductase Expression

Park, Se-Eun; Erdogan, Sedef; Hwang, Dahyun; Hwang, Seon-Wook; Han, Eun Hye; Lim, Young Hee

doi:10.1248/bpb.b16-00158

Cited by 24 publications

(22 citation statements)

References 40 publications

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“…Dexamethasone (DEX) was used to induce catagen in mice. In this study, BV promoted hair growth in mice by decreasing the levels of 5α-reductase and increasing keratinocyte growth factor (KGF), which stimulates follicular proliferation [35]. 5α-reductase enzymatically catalyzed the conversion of testosterone into DHT that has a higher affinity against androgen receptors than testosterone, which led to stimulating hair loss by the expression of genes associated with hair follicle minimization [36].…”

Section: Therapeutic Effects Of Bv In Skin Diseasesmentioning

confidence: 99%

Potential Therapeutic Applications of Bee Venom on Skin Disease and Its Mechanisms: A Literature Review

Kim

Park

Lee

2019

Toxins

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Skin is larger than any other organ in humans. Like other organs, various bacterial, viral, and inflammatory diseases, as well as cancer, affect the skin. Skin diseases like acne, atopic dermatitis, and psoriasis often reduce the quality of life seriously. Therefore, effective treatment of skin disorders is important despite them not being life-threatening. Conventional medicines for skin diseases include corticosteroids and antimicrobial drugs, which are effective in treating many inflammatory and infectious skin diseases; however, there are growing concerns about the side effects of these therapies, especially during long-term use in relapsing or intractable diseases. Hence, many researchers are trying to develop alternative treatments, especially from natural sources, to resolve these limitations. Bee venom (BV) is an attractive candidate because many experimental and clinical reports show that BV exhibits anti-inflammatory, anti-apoptotic, anti-fibrotic, antibacterial, antiviral, antifungal, and anticancer effects. Here, we review the therapeutic applications of BV in skin diseases, including acne, alopecia, atopic dermatitis, melanoma, morphea, photoaging, psoriasis, wounds, wrinkles, and vitiligo. Moreover, we explore the therapeutic mechanisms of BV in the treatment of skin diseases and cytotoxic effects of BV on skin disease-causing pathogens, including bacteria, fungi and viruses.

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Section: Therapeutic Effects Of Bv In Skin Diseasesmentioning

confidence: 99%

Potential Therapeutic Applications of Bee Venom on Skin Disease and Its Mechanisms: A Literature Review

Kim

Park

Lee

2019

Toxins

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“…The research on herbs and active constituents as hair growth promoters has been driven by their less toxicity, easy availability, low‐cost, patient compliance and more than one mode of biochemical action . Specific effects of herbal extracts, polyherbal formulations, flavonoids and natural compounds on DPCs have been examined . In vivo hair growth promoting effects as proof of concept are also mentioned.…”

Section: Hair Growth Promoting Effectmentioning

confidence: 99%

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Madaan

Verma

Singh

et al. 2018

Intern J of Cosmetic Sci

125

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Hair disorders such as hair loss (alopecia) and androgen dependent, excessive hair growth (hirsutism, hypertrichosis) may impact the social and psychological well-being of an individual. Recent advances in understanding the biology of hair have accelerated the research and development of novel therapeutic and cosmetic hair growth agents. Preclinical models aid in dermocosmetic efficacy testing and claim substantiation of hair growth modulators. The in vitro models to investigate hair growth utilize the hair follicle Dermal Papilla cells (DPCs), specialized mesenchymal cells located at the base of hair follicle that play essential roles in hair follicular morphogenesis and postnatal hair growth cycles. In this review, we have compiled and discussed the extensively reported literature citing DPCs as in vitro model to study hair growth promoting and inhibitory effects. A variety of agents such as herbal and natural extracts, growth factors and cytokines, platelet-rich plasma, placental extract, stem cells and conditioned medium, peptides, hormones, lipid-nanocarrier, light, electrical and electromagnetic field stimulation, androgens and their analogs, stress-serum and chemotherapeutic agents etc. have been examined for their hair growth modulating effects in DPCs. Effects on DPCs' activity were determined from untreated (basal) or stress induced levels. Cell proliferation, apoptosis and secretion of growth factors were included as primary end-point markers. Effects on a wide range of biomolecules and mechanistic pathways that play key role in the biology of hair growth were also investigated. This consolidated and comprehensive review summarizes the up-to-date information and understanding regarding DPCs based screening models for hair growth and may be helpful for researchers to select the appropriate assay system and biomarkers. This review highlights the pivotal role of DPCs in the forefront of hair research as screening platforms by providing insights into mechanistic action at cellular level, which may further direct the development of novel hair growth modulators.

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“…Several other natural products are shown to enhance the growth of DP cells in culture. For instance, the extract of a mixture of herbs ( Persea americana , Althaea officinalis , Chamaemelum nobile , Thymus vulgaris , Rosmarinus officinalis , Urtica dioica , and Aloe vera ), bee venom, and the extract of Asiasari radix enhance the growth of DP cells in culture 22‐24 . Interestingly, the former two also down‐regulate the expression of SRD5A2 , as the extract of P zeylanica .…”

Section: Discussionmentioning

confidence: 99%

Extract of Plumbago zeylanica enhances the growth of hair follicle dermal papilla cells with down‐regulation of 5α‐reductase type II

Yamada

Miki

Yamaguchi

et al. 2020

J of Cosmetic Dermatology

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Background Cellular senescence, a phenomenon of irreversible growth arrest of mammalian cells, is involved in various age‐related phenomena in organisms. Hair follicle dermal papilla (DP) cells play important roles in the regulation of hair growth and loss. Aims We examined the implication of cellular senescence of DP cells in androgenetic alopecia (AGA), the most common form of male hair loss, and searched for the compounds that have a beneficial effect on the prevention of AGA. Patients/Methods Expression of the 5α‐reductase type II (SRD5A2) gene, which plays a key role in the development of AGA, was examined by quantitative RT‐PCR and Western blotting analysis in DP cells. Besides, DP cells were cultured with the extracts of herbs used in traditional Ayurvedic medicine to search for the compounds that have a beneficial effect on the growth of DP cells. Results We found that expression of the SRD5A2 was up‐regulated in senescent DP cells. We also found that the herbal extract of Plumbago zeylanica (root) enhanced the growth of DP cells and down‐regulated the expression of SRD5A2 in DP cells. Further, plumbagin, an ingredient of P zeylanica, would be responsible for the above effects of P zeylanica. Conclusion These results suggested the possibility that senescent DP cells may have a role in the development of AGA through up‐regulating SRD5A2 expression, and the P zeylanica extract and plumbagin may suppress its development through enhancing the growth of DP cells and down‐regulating SRD5A2 expression in DP cells.

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Bee Venom Promotes Hair Growth in Association with Inhibiting 5α-Reductase Expression

Cited by 24 publications

References 40 publications

Potential Therapeutic Applications of Bee Venom on Skin Disease and Its Mechanisms: A Literature Review

Potential Therapeutic Applications of Bee Venom on Skin Disease and Its Mechanisms: A Literature Review

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Extract of Plumbago zeylanica enhances the growth of hair follicle dermal papilla cells with down‐regulation of 5α‐reductase type II

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