Beer But Not Wine, Hard Liquors, or Pure Ethanol Stimulates Amylase Secretion of Rat Pancreatic Acinar Cells In Vitro

Gerloff, Andreas; Singer, Manfred V.; Feick, Peter

doi:10.1111/j.1530-0277.2009.00983.x

Cited by 7 publications

(13 citation statements)

References 40 publications

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“…Therefore, recent studies investigated the direct effect of alcoholic beverages, especially beer, on pancreatic secretion of freshly isolated rat pancreatic acinar cells and the rat pancreatic acinar cell line AR4-2J [11,12]. The cell line retains many of the characteristics of pancreatic acinar cells in its differentiated state and is a general model to study stimulus-secretion coupling [13].…”

Section: Resultsmentioning

confidence: 99%

“…Lactate dehydrogenase measurement after long-term treatment (24 h) of AR4-2J cells indicated that the beer-induced amylase release is not due to protein release due to cell membrane damage [12]. Pre-treatment of AR4-2J cells with selective inhibitors of known mediators of stimulus-secretion coupling in pancreatic acinar cells has shown that beer-induced amylase secretion is mediated by activation of phospholipase C (PLC), binding of IP 3 to its receptor (IP 3 -R) and subsequent calcium release from intracellular stores.…”

Section: Resultsmentioning

confidence: 99%

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Beer and its Non-Alcoholic Compounds: Role in Pancreatic Exocrine Secretion, Alcoholic Pancreatitis and Pancreatic Carcinoma

Gerloff

Singer

Feick

2010

IJERPH

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In this article we provide an overview of the newest data concerning the effect of non-alcoholic constituents of alcoholic beverages, especially of beer, on pancreatic secretion, and their possible role in alcoholic pancreatitis and pancreatic carcinoma. The data indicate that non-alcoholic constituents of beer stimulate pancreatic enzyme secretion in humans and rats, at least in part, by direct action on pancreatic acinar cells. Some non-alcoholic compounds of beer, such as quercetin, resveratrol, ellagic acid or catechins, have been shown to be protective against experimentally induced pancreatitis by inhibiting pancreatic secretion, stellate cell activation or by reducing oxidative stress. Quercetin, ellagic acid and resveratrol also show anti-carcinogenic potential in vitro and in vivo. However, beer contains many more non-alcoholic ingredients. Their relevance in beer-induced functional alterations of pancreatic cells leading to pancreatitis and pancreatic cancer in humans needs to be further evaluated.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Beer and its Non-Alcoholic Compounds: Role in Pancreatic Exocrine Secretion, Alcoholic Pancreatitis and Pancreatic Carcinoma

Gerloff

Singer

Feick

2010

IJERPH

Self Cite

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“…Nowsze badania wskazują, że jedynym napojem, który ewidentnie stymuluje egzokrynną sekrecję trzustkową, jest piwo [86]. Za ten efekt mają być odpowiedzialne zawarte w nim, jeszcze niezidentyfikowane, składniki niealko-holowe [87][88][89]. Zdaniem badaczy japońskich jednym z takich związków może być N-metylotyramina [90].…”

Section: Wpływ Napojów Alkoholowych Na Trzustkęunclassified

Alcohol and the digestive system – should it always be blamed?

Kasicka-Jonderko¹

2012

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“…Therefore, we recently investigated the direct effect of alcoholic beverages, especially beer, on pancreatic secretion of freshly isolated rat pancreatic acinar cells and the rat pancreatic acinar cell line AR4-2J [23,24]. The cell line retains in its differentiated state much of the characteristics of pancreatic acinar cells and is a general model to study stimulus-secretion coupling [25].…”

Section: Beer and Pancreatic Secretionmentioning

confidence: 99%

Pancreas – Non-Alcoholic Constituents and Their Effects

Gerloff

Feick

Singer

2010

Dig Dis

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Alcoholic beverages contain numerous non-alcoholic compounds that could have beneficial or pathological effects. For example, up to now in beer more than 2,000 and in wine more than 1,000 organic and inorganic constituents have been identified. Whereas the role of alcohol (ethanol) in the development of pancreatic diseases – in particular acute and chronic pancreatitis – has been intensively investigated, only little is known about the effects of non-alcoholic compounds in this context. Some of the non-alcoholic constituents have been shown to be biologically active, although discussions of the results in appropriate publications were often not performed with regard to their consumption as a mixture in alcoholic beverages. In this article we provide an overview about the newest data concerning the effect of non-alcoholic constituents of alcoholic beverages, especially of beer, on pancreatic secretion and their possible role in alcoholic pancreatitis. The data indicate that non-alcoholic constituents of beer stimulate pancreatic enzyme secretion in humans and rats, at least in part, by direct action on pancreatic acinar cells. However, there is accumulating evidence that non-alcoholic compounds of alcoholic beverages exert different effects on the pancreas. The effects and mechanisms of most single compounds and their combinations are still unknown and thus caution is required in attempting to draw firm conclusions on the effect of non-alcoholic compounds of alcoholic beverages on defining alcoholic etiology of pancreatitis.

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Beer But Not Wine, Hard Liquors, or Pure Ethanol Stimulates Amylase Secretion of Rat Pancreatic Acinar Cells In Vitro

Cited by 7 publications

References 40 publications

Beer and its Non-Alcoholic Compounds: Role in Pancreatic Exocrine Secretion, Alcoholic Pancreatitis and Pancreatic Carcinoma

Beer and its Non-Alcoholic Compounds: Role in Pancreatic Exocrine Secretion, Alcoholic Pancreatitis and Pancreatic Carcinoma

Alcohol and the digestive system – should it always be blamed?

Pancreas – Non-Alcoholic Constituents and Their Effects

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