Beginning Insulin Treatment of Obese Patients With Evening 70/30 Insulin Plus Glimepiride Versus Insulin Alone

Abstract

Injection of 70/30 insulin before supper safely restored glycemic control of type 2 diabetes not controlled by glimepiride alone. Control was restored more rapidly and with less injected insulin when glimepiride was continued.

Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal KATP channels

“…Several studies have suggested that glimepiride, used for the treatment of type 2 diabetes, may give better glycaemic control and a ect cardiovascular variables less than does glibenclamide (Sonnenberg et al, 1997;Langtry & Balfour, 1998;Riddle & Schneider, 1998;Schade et al, 1998;ElReyani et al, 1999). It has also been shown recently that glimepiride, unlike glibenclamide, does not abolish the cardioprotective e ects of IPC (Klepzig et al, 1999;Mocanu et al, 2001).…”

“…Glimepiride is a relatively new sulphonylurea used in the treatment of type 2 diabetes (Klepzig et al, 1999;Sonnenberg et al, 1997;Langtry & Balfour, 1998;Riddle & Schneider, 1998;Schade et al, 1998). Glimepiride has become an attractive alternative to the more common antidiabetic drug glibenclamide.…”

Management of Type 2 Diabetes (Niddm)

“…Sulfonylurea and insulin therapy: It decreases fasting serum glucose by 50-80 mgldl and glycosylated haemoglobin by 1-2% [20][21][22][23][24]. Glycemic control improves in patients who have the worst glycemic control except when fasting blood glucose level is more than 300 mg/dl and in patients with the greatest degree of obesity.…”

“…Another, adjunctive OHA therapy, patients uncontrolled with or requiring high doses of insulin monotherapy can be given OHA in the hope to achieve better glycemic control and decrease in the doses of insulin. Additional insulin therapy has more patient acceptance, improved glycemic control, rapid glycemic control, improved lipid profile, decreased insulin requirement, less weight gain and cost effectiveness [20][21][22][23][24][25][26][27][28][29].…”

Starting Insulin Therapy in Type 2 Diabetic Patients

“…There is no agreed upon optimal mode of initiating insulin in this situation. In recent years, adding NPH insulin at bedtime (1)(2)(3) or 70/30 premixed insulin at suppertime (4) to the oral medications have been studied. Adding NPH insulin at bedtime has yielded similar improvements in control as two or more injections of insulin for 3 (1), 6 (2), or 12 (3) months.…”