Behandling af depressive tilstande med Flupentixol

Sonne, Lass Mahler

doi:10.3109/08039486609097604

Cited by 21 publications

(1 citation statement)

References 5 publications

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“…The thioxanthene derivative flupenthixol is of established value in the treatment of schizophrenia.' After some early reports,2 3 Reiter4 described his uncontrolled impression of the antidepressant effect of flupenthixol in low doses in an extensive outpatient series. The recovery rate was over 60%, and he claimed that flupenthixol was quick acting, effective in low doses, and without significant unwanted effects.…”

Section: Introductionmentioning

confidence: 99%

A controlled comparison of flupenthixol and amitriptyline in depressed outpatients.

Young¹,

Hughes²,

Lader³

1976

BMJ

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high-frequency stimulator that blankets the re-entry zone, and thereby fortuitously induces a suitably timed extrasystole ;3 and the variable-hysteresis orthorhythmic pacemaker.2 These are all experimental, and implantable units are not available. Fixedrate pacing, however, is known to be of value in some cases, and this may be achieved either by using a demand pacemaker with a magnetic reed switch activated by an external magnet' or by holding an external induction-coil5 or radio-frequency pacemaker6 over the site of an implanted receiver. These latter methods, however, need the active intervention of the patient. If tachycardia is associated with syncope, or if serious attacks occur during sleep, the patient may be at considerable risk before the pacemaker can be activated. Here the dual-demand pacemaker may help. By automatically switching from the demand to the fixed-rate mode in response to the rate of the heart, units can be tailored to function at rates corresponding to the patient's tachycardia. Careful intracardiac electrophysiological studies'2 will show whether the method is suitable for a particular patient. The unit can easily be tested at follow-up if competitive atrial pacing is induced by an external magnet applied over the generator, which will initiate an attack after a variable period. If the magnet is then removed the unit can be seen to function and terminate the attack.Both of our patients had pre-excitation, and such units may well have their greatest application in this field. When the bypass is left-sided, stimulation from the coronary sinus"3 offers the facility to influence both the nodal and extranodal limbs of the tachycardia circuit and may thus increase the chance of terminating re-entry. We have studied several other patients who were satisfactorily controlled by antiarrhythmic drugs in whom dual-demand pacemaking was tested successfully. For selected cases the dual-demand pacemaker offers an automatic unit that can be pretested and that works in response to the patient's own tachycardia, switching itself off after the tachycardia has been controlled unless bradycardia (perhaps due to sinoatrial disease) persists, when it acts to prevent both syncope and further recurrences.This work was supported by a grant from the British Heart Foundation. We are grateful to Dr Philippe Coumel, who helped with the investigation of case 1, for advice in the development of the pacemaker, and to Dr Celia Oakley, who kindly referred the patients. References

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Section: Introductionmentioning

confidence: 99%