Behandlung des Hirsutismus mit Cyproteronacetat<sup>*</sup>

Hammerstein, J.; Cupceancu, B

doi:10.1055/s-0028-1111126

Cited by 122 publications

(24 citation statements)

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“…Four dropped out due to family reasons. Twenty women were treated with 50 Ìg of ethinylestradiol daily for 21 days per month and 100 mg of cyproterone acetate (EE-CA) daily for 10 days in an inverse cycle originally described by Hammerstein [15]. Eight women were treated with a GnRH analogue (goserelin, Zoladex ® , Zeneca, UK) 3.6 mg implanted subcutaneous every 28 days.…”

Section: Treatmentmentioning

confidence: 99%

Effect of Two Modes of Antiandrogen Treatment on Insulin Sensitivity and Serum Leptin in Women with PCOS

Krotkiewski

Landin²,

Dahlgren³

et al. 2003

Gynecol Obstet Invest

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Androgens are suggested to interact with leptin production and with insulin sensitivity in both polycystic ovary syndrome (PCOS) and obesity. The aim of the study was to follow these interactions along with two forms of antiandrogen treatment. Twenty women with PCOS were treated with ethinylestradiol and high dose of cyproteroneacetate (EE-CA) and 8 with the gonadotrophin-releasing hormone (GnRH) analogue goserelin for 6 months. The patients were divided into a low and a high body weight group and compared with a group of overweight women without PCOS. Both treatments resulted in a significant reduction of free testosterone but the concentration of leptin remained unchanged. EECA treatment resulted in deterioration and GnRH in improvement of insulin sensitivity. Serum leptin correlated only with body weight and body fat. It is concluded that leptin levels do not adequately reflect changes in insulin sensitivity or androgen levels after short-term antiandrogen or antigonadotropin treatment.

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Section: Treatmentmentioning

confidence: 99%

Effect of Two Modes of Antiandrogen Treatment on Insulin Sensitivity and Serum Leptin in Women with PCOS

Krotkiewski

Landin²,

Dahlgren³

et al. 2003

Gynecol Obstet Invest

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“…These side effects can be avoided by combining a cyclic administration of cyproterone acetate with ethinyl estradiol, as suggested by H ammerstein and C upceancy [2]. In this way we treated about 15 patients.…”

Section: Resultsmentioning

confidence: 99%

Clinical-Pharmacological Investigation of Cyproterone Acetate

Wayjen¹,

Ende²

1971

Gynecol Obstet Invest

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(1) The antiandrogenic steroid cyproterone acetate exerted a strongly negative nitrogen balance in 8 young male volunteers, the degree of which correlated with the dose administered. In a male patient of 77 years with cancer of the prostate, this catabolic effect proved to be much weaker. In 8 female patients with hirsutism, administration of cyproterone acetate resulted only then in a negative nitrogen balance when the food was deficient in calories and protein. Continuous treatment with cyproterone acetate in female patients is not feasible because of strongly progestational side-effects. These side effects can be avoided by combining cyproterone acetate with ethinyl estradiol as an ‘inverted sequential scheme’, according to Hammerstein and Cupceancy [2]. In most female patients with hirsutism, good or satisfactory results can be obtained by a continuous cyproterone acetate therapy or by the combination treatment of Hammerstein and CUPCEANCY [2].

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“…Therefore, the therapy of choice in the treatment of hirsutism should be com pounds able to compete with T at tire hair follicle site. Hammerstain and Cupceancu (13) and Ismail et al (14) emphasize the efficacy of cyproterone acetate, one of the most powerful progestagens, which exerts a potent antiandrogenic action not only decreasing the plasma T levels, but also inhibiting its action in the peripheral sites (12). Investigations are in progress in this Institute in an attempt to demonstrate a regression of hirsutism also in those cases failing to respond to other hormonal treatments.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Estimation of Four Plasma Androgens Before and After Dynamic Tests in Women with Hirsutism: Correlation with Long-Term Therapy

Sciarra¹,

Toscano²,

Concolino³

et al. 1976

Horm Res

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Concentrations of testosterone, △⁴-androstenedione, dihydrotestosterone and Δ⁵-androstenediol were measured in 12 patients affected by hirsutism associated with menstrual disorders. Testosterone was elevated in 9 cases, in whom high levels of Δ⁴-androstenedione and dihydrotestosterone were found, and normal in 3 cases, 2 of which presented high values of dihydrotestosterone and one high levels of Δ⁵-androstenediol. In some hirsute females therefore, other androgens, such as dihydrotestosterone and Δ⁵-androstenediol, play a role in the pathogenesis of hirsutism. Dexamethasone and estrogen progestin combinations were administered for dynamic tests, and results in most cases provided useful information in the selection of suitable long-term therapy.

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Behandlung des Hirsutismus mit Cyproteronacetat^*

Cited by 122 publications

References 1 publication

Effect of Two Modes of Antiandrogen Treatment on Insulin Sensitivity and Serum Leptin in Women with PCOS

Effect of Two Modes of Antiandrogen Treatment on Insulin Sensitivity and Serum Leptin in Women with PCOS

Clinical-Pharmacological Investigation of Cyproterone Acetate

Simultaneous Estimation of Four Plasma Androgens Before and After Dynamic Tests in Women with Hirsutism: Correlation with Long-Term Therapy

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Behandlung des Hirsutismus mit Cyproteronacetat*

Cited by 122 publications

References 1 publication

Effect of Two Modes of Antiandrogen Treatment on Insulin Sensitivity and Serum Leptin in Women with PCOS

Effect of Two Modes of Antiandrogen Treatment on Insulin Sensitivity and Serum Leptin in Women with PCOS

Clinical-Pharmacological Investigation of Cyproterone Acetate

Simultaneous Estimation of Four Plasma Androgens Before and After Dynamic Tests in Women with Hirsutism: Correlation with Long-Term Therapy

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Behandlung des Hirsutismus mit Cyproteronacetat^*