Behandlung des trockenen Auges mit Hyaluronat-Augentropfen

Horwath, J.; Schmut, O.; Farr, C. W.; Faulborn, J.

doi:10.1007/bf03163946

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…Oxidative stress destroys proteins, mucous components and lipids contained in the tear film so that the tear film ultimately loses its stability. Precorneal tear film break-up causes the characteristic symptoms of the dry eye syndrome [9,15,16,18,19].…”

Section: Introductionmentioning

confidence: 99%

Anti-oxidative capacity of various artificial tear preparations

Rieger¹

2001

Graefe's Arch Clin Exp Ophthalmol

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The anti-oxidative capacity of artificial tear preparations varies widely. While some are strong anti-oxidants, others are less active or even act as oxidants. If the carefully elicited history of patients with dry eyes suggests that noxious environmental factors may be causally involved, artificial tears which are not just lubricants or contain wetting agents, but act as anti-oxidants, should be chosen for treatment from the many commercially available preparations. Such an etiology-oriented concept would probably improve the success rate of treatment for dry eyes.

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Section: Introductionmentioning

confidence: 99%

Anti-oxidative capacity of various artificial tear preparations

Rieger¹

2001

Graefe's Arch Clin Exp Ophthalmol

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“…Since the treatment of chemical injuries to the ocular surface with HA was already recommended in 1984 [13,14] and we have also had long experience in treating dry eye disease with HA [18], we decided to use it in this study. We applied HA in a concentration of 0.025% because former experiments have shown that, if the concentration of HA in the cell culture medium of human conjunctival cells gets beyond 0.05%, the human conjunctival cells start to lose differentiation and die.…”

Section: Discussionmentioning

confidence: 99%

Positive Influence of Hyaluronate on Cell Vitality of Human Conjunctival Cells after Alkali Injuries

Rabensteiner¹,

Trummer²,

Spitzenberger³

et al. 2009

Ophthalmologica

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Background:To analyse the influence of hyaluronate (HA) on the cell vitality of human conjunctival cells after chemical injuries from NaOH or alkali-containing household cleaners. Methods:Human conjunctival cells (Chang cells) were incubated either with NaOH solutions or dilutions of household cleaners. HA (0.025%) was added to the cell culture medium of part of the cells subsequent to chemical injuring. After 24 h the cell vitality of the HA-incubated cells, determined by MTS assay (Cell Titer 96® Aqueous One Solution Cell Proliferation Assay), was compared to the control cells without HA addition. Results: The addition of HA to the cell culture medium subsequent to chemical injuring resulted in a significantly lower decrease in cell vitality (mean difference: 11.79; p = 0.00; CI = 98%). Conclusion: Because HA attenuates the decrease in cell vitality of alkali-damaged human conjunctival cells, formulations containing HA may be recommended for the treatment of chemical injuries to the anterior part of the eye.

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Eine neue Möglichkeit der Behandlung der Keratokonjunktivitis sicca durch Besprühung mit einer Öl-in-Wasser-Emulsion

Schachner¹,

Rieger²,

Horwath‐Winter

et al. 2005

Spektrum Augenheilkd

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Zusammenfassung.Hintergrund: Trotz der vielfaltigen Behandlungsmoglichkeiten bei trockenem Auge gibt es bisher keine Therapie, die eine vollstandige Heilung dieser Erkrankung ermoglicht. Eine Erweiterung des Therapiespektrums stellt die Bespruhung der Augen von Patienten mit Keratokonjunktivitis sicca mit einer Ol-in-Wasser-Emulsion dar.Die Wirkung dieser neuen Behandlungsmethode wurde untersucht.Material and Methode: 25 Patienten mit trockenem Auge wurden mit einem Aerosol, das Sojabohnenol, mittelkettige Triglyceride and Phospholipide enthalt, bespraht. Die Behandlungszeit betrug jeweils 7 Minuten pro Auge taglich bei insgesamt 14 Anwendungen. Mit einem Fragebogen wurde vor and nach der Behandlung der Symptomscore erhoben. Die Beurteilung des Tranenmeniskus and der lidkantenparallelen Bindehautfalten, die TranenfilmaufreiBzeit, die Fluorescein-Anfarbung der Hotnhaut and der Schirmertest in Lokalanasthesie wurden durchgef ihrt.Resultate: Eine signifikante Verbesserung der subjektiven Beschwerden, der Tranenfilmaufreiflzeit, der Hornhautanfarbung and des Tranenmeniskus wurde beobachtet. Die lidkantenparallelen Falten and der Schirmertest zeigten nach der Behandlung keine signifikante Veranderung.Schlussfolgerung: Die neue Methode der Bespruhung der Augen von Patienten mit Sicca-Symptomatik mit einer Ol-in-Wasser-Emulsion stellt eine Erweiterung des Therapiespektrums zur Behandlung dieser Erkrankung des vorderen Augenabschnitts dar.Schliisselworter: Keratokonjunktivitis sicca, Therapie, Besprfthung, Ol-in-Wasser-Emulsion.A new method of dry eye treatment with an oil-inwater-emulsion spray Summary. Background: Despite many different therapies of dry eye syndrome a complete healing of this disease is not achievable until now. An enlargement of the therapy spectrum is the spraying therapy for eyes of patients with kerato-* Herrn Univ.-Prof. Dr. Klaus W. Ruprecht zum 65. Geburtstag gewidmet.conjunctivitis sicca with an oil-in-water-emulsion. The effect of this new treatment was investigated.Materials and methods: 25 patients with dry eye were sprayed with an aerosol containing soja bean oil, triglycerides of middle chain length and phospholipides. A daily treatment for 7 minutes of each eye was performed for 14 days. Before and after therapy the symptom score was evaluated by a questionnaire. Inspection of the tear meniscus and of the lid-parallel conjunctival folds, the break-up-time, fluorescein-staining of the cornea and the Schirmertest in local anaesthesia were performed.Results: A significant improvement of subjective symptoms, of the break-up-time, of the corneal staining and of the tear meniscus was observed. The lid-parallel conjunctival folds, and Schirmertest values showed no significant change after treatment.Conclusions: This new method by spraying the eyes of patients with sicca symptoms with an oil-in-water-emulsion represents an enlargement of the therapies for treatment of this disease of the anterior part of the eye.

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Behandlung des trockenen Auges mit Hyaluronat-Augentropfen

Cited by 5 publications

References 7 publications

Anti-oxidative capacity of various artificial tear preparations

Anti-oxidative capacity of various artificial tear preparations

Positive Influence of Hyaluronate on Cell Vitality of Human Conjunctival Cells after Alkali Injuries

Eine neue Möglichkeit der Behandlung der Keratokonjunktivitis sicca durch Besprühung mit einer Öl-in-Wasser-Emulsion

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