Anti-oxidative capacity of various artificial tear preparations

Abstract

The anti-oxidative capacity of artificial tear preparations varies widely. While some are strong anti-oxidants, others are less active or even act as oxidants. If the carefully elicited history of patients with dry eyes suggests that noxious environmental factors may be causally involved, artificial tears which are not just lubricants or contain wetting agents, but act as anti-oxidants, should be chosen for treatment from the many commercially available preparations. Such an etiology-oriented concept would probably improve the success rate of treatment for dry eyes.

Evaluation of oxidative stress levels in the conjunctival epithelium of patients with or without dry eye, and dry eye patients treated with preservative-free hyaluronic acid 0.15 % and vitamin B12 eye drops

“…These results indicate that eye drops containing hyaluronic acid 0.15 % and vitamin B12 improve oxidative stress as well as symptoms of dry eye. Our findings The P-value was calculated by t test are supported by recent studies that have also shown that hyaluronic acid and vitamin B12 have antioxidant activity in ophthalmology and other diseases involving ROS [31][32][33][34][35][36][37][38].…”

The effect of iodide iontophoresis on the antioxidative capacity of the tear fluid

“…The significant improvement of the antioxidative protective capacity of the tear fluid by iodide iontophoresis in Bad Hall/ Austria is certainly an essential expansion of the treatment of dry eye syndrome, especially in cases with oxidative stress to the ocular surface [5,9,21,31,32,54,57,61,64] Further investigations are needed to elucidate iodine effects on other factors of dry eye disorders, for instance inflammation, which is another important finding in dry eye syndrome.…”

Iodide protection from UVB irradiation-induced degradation of hyaluronate and against UVB-damage of human conjunctival fibroblasts

“…The mechanism of protection by iodide is likely to include an antioxidative action as discussed by several authors [31,45,47,48].…”

“…In preparations containing iodide, antioxidative and radical scavenger effects have been observed [31,45,47,48]. Also treatment of the ocular surface with brine containing iodide contributes to an increase of the antioxidant status in tear fluid [32].…”