Behavior-dependent
            <i>cis</i>
            regulation reveals genes and pathways associated with bower building in cichlid fishes

York, Ryan A.; Patil, Chinar; Abdilleh, Kawther; Johnson, Zachary V.; Conte, Matthew A.; Genner, Martin J.; McGrath, Patrick T.; Fraser, Hunter B.; Fernald, Russell D.; Streelman, J. Todd

doi:10.1073/pnas.1810140115

Cited by 55 publications

(75 citation statements)

References 58 publications

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“…If hindbrain volume evolved mosaically, as suggested by our allometric analyses, then pairwise tests of phenotypic variation controlling for phylogeny should reveal a lack of similarity among closely related species in the size of this brain region. Phylogenetic ANOVA using a genome-wide maximum likelihood phylogeny [21] revealed significant variation between pit and castle species independent of relatedness (F = 13.18, 1 d.f., p < 0.05). Plotting the distribution of volumetric measures along the full tree demonstrates this pattern (Figure 1B).…”

Section: Resultsmentioning

confidence: 99%

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Behavioral evolution drives hindbrain diversification among Lake Malawi cichlid fish

York

Byrne

Abdilleh

et al. 2018

Preprint

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31The evolutionary diversification of animal behavior is often associated with changes in 32 the structure and function of nervous systems. Such evolutionary changes arise either through 33 alterations of individual neural components ("mosaically") or through scaling of the whole brain 34 ("concertedly"). Here we show that the evolution of a specific courtship behavior in Malawi 35 cichlid fish, the construction of mating nests known as bowers, is associated with rapid, 36 extensive, and specific diversification of orosensory, gustatory centers in the hindbrain. We find 37 that hindbrain volume varies significantly between species that build pit (depression) compared 38 to castle (mound) type bowers and that hindbrain features evolve rapidly and independently of 39 phylogeny among castle-building species. Using immediate early gene expression, we confirmed 40 a functional role for hindbrain structures during bower building. Comparisons of bower building 41 species in neighboring Lake Tanganyika show patterns of neural diversification parallel to those 42 in Lake Malawi. Our results suggest that mosaic brain evolution via alterations to individual 43 brain structures is more extensive and predictable than previously appreciated. 44 45 behaviors vary widely, as do their neural phenotypes [1]. Evolutionary 63 neuroscience identifies how the brain diversifies over time and space in response to selective 64 pressures [2]. A key goal of evolutionary neuroscience has been to identify whether brain 65 structures evolve independently ("mosaically") or in tandem with each other as they reflect key 66 life history traits, especially behavior [3][4][5][6]. While a number of studies have linked variation in 67 brain structure with other traits across evolutionary time [2, 7-9], it remains unclear whether or 68 not this variation is predictable. Specifically, when similar behavioral traits evolve among two or 69 more species, do their neural bases evolve correspondingly? If parallel brain evolution is 70 predictable then it may be possible to understand general principles of neural organization and 71 function across animals. This would expand our ability to manipulate brain function, but if this is 72 not true, new strategies will be needed to reveal the mechanisms of brain evolution. 73Fishes, as both the most speciose (50% of extant vertebrates) and most varied vertebrate 74 radiation [10] offer opportunities to answer these questions. Fish species live in diverse 75 ecological, sensory, and social environments and have evolved elaborate variations in neural 76 structure and function from a common basic ground plan [11] making rapid and variable 77 diversification of brain structures a broad and general feature of their evolution [10]. 78The cichlid fishes of Lake Malawi, Africa offer a particularly striking model of these 79 patterns of diversification. Although geologically young (less than 5 million years old), Lake 80Malawi contains at least 850 species of cichlids [12] that, based on molecular phylogenetic 81 analyses...

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Section: Resultsmentioning

confidence: 99%

“…Phylogenetic comparisons were conducted in R [38]. The packages SNPhylo [31] and ape [32] were used to construct ultrametric phylogenies for the Lake Malawi species from whole genome SNP data [21]. A previously published phylogeny was used to infer phylogenetic relationships of the Lake Victoria and Tanganyika species [35].…”

Section: Methodsmentioning

confidence: 99%

Behavioral evolution drives hindbrain diversification among Lake Malawi cichlid fish

York

Byrne

Abdilleh

et al. 2018

Preprint

Self Cite

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“…In order to check that there were no biases in alleles assignment to one of the two species, we analyzed the ratios of the species alleles, for every gene, and checked that they were not systematically biased to either one of the two species. The log 2 fold changes of the species alleles were centred around 0, suggesting no obvious bias in alleles assignment 78 ( Supplementary Fig. 7).…”

Section: Methodsmentioning

confidence: 92%

Visual mate preference evolution during butterfly speciation is linked to neural processing genes

Rossi

Hausmann²,

Thurman

et al. 2020

Nat Commun

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Many animal species remain separate not because their individuals fail to produce viable hybrids but because they “choose” not to mate. However, we still know very little of the genetic mechanisms underlying changes in these mate preference behaviours. Heliconius butterflies display bright warning patterns, which they also use to recognize conspecifics. Here, we couple QTL for divergence in visual preference behaviours with population genomic and gene expression analyses of neural tissue (central brain, optic lobes and ommatidia) across development in two sympatric Heliconius species. Within a region containing 200 genes, we identify five genes that are strongly associated with divergent visual preferences. Three of these have previously been implicated in key components of neural signalling (specifically an ionotropic glutamate receptor and two regucalcins), and overall our candidates suggest shifts in behaviour involve changes in visual integration or processing. This would allow preference evolution without altering perception of the wider environment.

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“…In order to check that there were no biases in alleles assignment to one of the two species, we analyzed the ratios of the species alleles, for every gene, and checked that they were not systematically biased to either one of the two species. The log2 fold-changes of the species alleles were centered around 0, suggesting no obvious bias in alleles assignment 79 ( Supplementary figure 7).…”

Section: Inference Of Bc3 Hybrids Genome Composition In Order To Permentioning

confidence: 94%

Visual mate preference evolution during butterfly speciation is linked to neural processing genes

Rossi

Hausmann²,

Thurman

et al. 2020

Preprint

View full text Add to dashboard Cite

Many animal species remain separate not because they fail to produce viable hybrids, but because their individuals “choose” not to mate. However, we still know very little of the genetic mechanisms underlying changes in these mate preference behaviours. Heliconius butterflies display bright warning patterns, which they also use to recognize conspecifics. Here, we couple QTL for divergence in visual preference behaviours with population genomic and gene expression analyses of neural tissue (central brain, optic lobes and ommatidia) across development in two sympatric Heliconius species. Within a region containing 200 genes, we identify five genes that are strongly associated with divergent visual preferences. Three of these have previously been implicated in key components of neural signalling (specifically an ionotropic glutamate receptor and two regucalcins), and overall our candidates suggest shifts in behaviour involve changes in visual integration or processing. This would allow preference evolution without altering perception of the wider environment.

show abstract

Behavior-dependent cis regulation reveals genes and pathways associated with bower building in cichlid fishes

Cited by 55 publications

References 58 publications

Behavioral evolution drives hindbrain diversification among Lake Malawi cichlid fish

Behavioral evolution drives hindbrain diversification among Lake Malawi cichlid fish

Visual mate preference evolution during butterfly speciation is linked to neural processing genes

Visual mate preference evolution during butterfly speciation is linked to neural processing genes

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