Behavior Disorder After Encephalitis Caused by Dengue

Baldaçara, Leonardo; Ferreira, Juliane Rosa; Filho, L.C.P. Seixas; Venturini, Ranielly Ribeiro; Coutinho, Olivia Maria Veloso Costa; Camarço, W.C.; Fernandes, Camila Campitelli; Júnior, Emílio Vasques

doi:10.1176/appi.neuropsych.12020040

Cited by 12 publications

(12 citation statements)

References 4 publications

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“…According to Soares et al, dengue is the first reason for encephalitis with normal CSF cellularity in 75% of patients with viral meningitis and encephalitis in a dengue endemic region, followed by Herpes Simplex Virus 1 (HSV1) and mild encephalitis (Soares et al, 2011 ). Neuroimaging of dengue encephalitis yields divergent data, with normal findings in most cases (Baldaçara et al, 2013 ; Madi et al, 2014 ). In case of abnormal neuroimaging findings, magnetic resonance imaging (MRI) has advantages over cranial computed tomography (CT) in revealing cerebral lesions in dengue encephalitis.…”

Section: Central Neurological System Complicationsmentioning

confidence: 99%

“…Encephalopathy caused by dengue fever can be reflected by reduced sensitivity, cognitive impairment, convulsions, and personality and behavior disorders, including acute mania, depression, emotional lability, anxiety, psychosis, and agoraphobia (Rittmannsberger et al, 2010 ; Baldaçara et al, 2013 ; Srivastava et al, 2013 ). In a review reporting cases of dengue fever associated with neurological disorders in 2012, encephalopathy was considered by far the most encountered complication (Oehler et al, 2012 ).…”

Section: Central Neurological System Complicationsmentioning

confidence: 99%

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Neurological Manifestations of Dengue Infection

Zhang

Liu

et al. 2017

Front. Cell. Infect. Microbiol.

161

146

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Dengue counts among the most commonly encountered arboviral diseases, representing the fastest spreading tropical illness in the world. It is prevalent in 128 countries, and each year >2.5 billion people are at risk of dengue virus infection worldwide. Neurological signs of dengue infection are increasingly reported. In this review, the main neurological complications of dengue virus infection, such as central nervous system (CNS), peripheral nervous system, and ophthalmic complications were discussed according to clinical features, treatment and possible pathogenesis. In addition, neurological complications in children were assessed due to their atypical clinical features. Finally, dengue infection and Japanese encephalitis were compared for pathogenesis and main clinical manifestations.

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Section: Central Neurological System Complicationsmentioning

confidence: 99%

Section: Central Neurological System Complicationsmentioning

confidence: 99%

Neurological Manifestations of Dengue Infection

Zhang

Liu

et al. 2017

Front. Cell. Infect. Microbiol.

161

146

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“…Treatment with compound 10 reduced DENV-2 loads in several organs of mice, including the central nervous system (CNS), and ameliorated tissue damage due to infection. DENV is not classically considered a neurotropic virus, but it may cause encephalitis in humans (31,32) and in immunosuppressed mice, including A129 Ϫ/Ϫ and AG129 Ϫ/Ϫ mice. Here we demonstrated that compound 10 was also able to prevent DENV dissemination to and replication in the CNS of A129 mice, suggesting that this compound may cross the blood-brain barrier.…”

Section: Zandi Et Al Antimicrobial Agents and Chemotherapymentioning

confidence: 99%

Nucleoside Analogs with Selective Antiviral Activity against Dengue Fever and Japanese Encephalitis Viruses

Zandi

Bassit

Amblard

et al. 2019

Antimicrob Agents Chemother

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Dengue virus (DENV) and Japanese encephalitis virus (JEV) are important arthropod-borne viruses from the Flaviviridae family. DENV is a global public health problem with significant social and economic impacts, especially in tropical and subtropical areas. JEV is a neurotropic arbovirus endemic to east and southeast Asia. There are no U.S. FDA-approved antiviral drugs available to treat or to prevent DENV and JEV infections, leaving nearly one-third of the world's population at risk for infection. Therefore, it is crucial to discover potent antiviral agents against these viruses. Nucleoside analogs, as a class, are widely used for the treatment of viral infections. In this study, we discovered nucleoside analogs that possess potent and selective anti-JEV and anti-DENV activities across all serotypes in cell-based assay systems. Both viruses were susceptible to sugar-substituted 2=-C-methyl analogs with either cytosine or 7-deaza-7-fluoro-adenine nucleobases. Mouse studies confirmed the anti-DENV activity of these nucleoside analogs. Molecular models were assembled for DENV serotype 2 (DENV-2) and JEV RNA-dependent RNA polymerase replication complexes bound to nucleotide inhibitors. These models show similarities between JEV and DENV-2, which recognize the same nucleotide inhibitors. Collectively, our findings provide promising compounds and a structural rationale for the development of direct-acting antiviral agents with dual activity against JEV and DENV infections.KEYWORDS Dengue virus, Japanese encephalitis virus, antiviral agents, nucleoside analogs D engue virus (DENV) and Japanese encephalitis virus (JEV) are members of the genus Flavivirus, belonging to the family Flaviviridae. Many flaviviruses are arthropod borne and cause severe infections in humans and vertebrate animals. DENV has four serotypes (DENV-1 to DENV-4), which collectively pose a health threat to 2.5 billion people worldwide, with 50 million to 100 million human infections and 500,000 cases of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) annually (1-3). JEV is one of the most important neurotropic flaviviruses that causes encephalitis in humans. Symptoms range from mild febrile illness to mortal illness, especially in children, with about 67,900 cases each year (4). JEV is endemic in eastern and southern Asia (including China, Indonesia, Nepal, Thailand, Saipan Island, Pakistan, and the Torres Strait) and Australia, with fatality rates of 20% to 30% and life-long neurological impairments and sequelae among one-half of the survivors (5-8). Despite a licensed vaccine to prevent JEV infection, infections occur annually due to a lack of complete coverage and access (9). A tetravalent DENV vaccine also exists but remains partially on July 10, 2020 by guest http://aac.asm.org/ Downloaded fromArg474. The triphosphate group forms electrostatic interactions with Arg474, Lys694, and two active site Mn 2ϩ ions.Nucleoside inhibitors of DENV. The same 14 nucleoside analogs were assayed against DENV using a BHK-21 cell line harboring the...

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“…36,39 But, the analysis was considered normal in the other two reports. 27,42 Brain imaging studies such as computed tomography [25][26][27]34,35,41 and magnetic resonance imaging 32,33,36,38 in most reports were normal. Metabolic derangements, including elevated liver enzymes, 24,25 electrolyte abnormalities, 27 vasculitis with capillary leak, and fluid extravasations, were postulated.…”

Section: Postulated Mechanismsmentioning

confidence: 99%

Dengue and Psychiatry: Manifestations, Mechanisms, and Management Options

Dinakaran

Sreeraj

Venkatasubramanian

2021

Indian Journal of Psychological Medicine

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Dengue is an arboviral infection endemic in tropical countries. Neurological sequelae to dengue infection are not uncommon, and psychiatric manifestations are increasingly reported. This narrative review aims to present the varied manifestations, postulated mechanisms, and the available treatment options for psychiatric morbidity associated with dengue. The evidence available from eight observational studies is summarized in this review. Depression and anxiety are noted to be prevalent during both the acute and convalescent stages of the infection. The presence of encephalopathy and other neurological conditions is not a prerequisite for developing psychiatric disorders. However, treatment options to manage such psychiatric manifestations were not specified in the observational studies. Anecdotal evidence from case reports is outlined. Special attention is paid to the role of epigenetic modifications following dengue infections and the role of histone deacetylase inhibitors in the management. DNA methylation inhibitors such as valproic acid play a significant role in reversing stress-, viral-, or drug-induced epigenetic modifications.

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Behavior Disorder After Encephalitis Caused by Dengue

Cited by 12 publications

References 4 publications

Neurological Manifestations of Dengue Infection

Neurological Manifestations of Dengue Infection

Nucleoside Analogs with Selective Antiviral Activity against Dengue Fever and Japanese Encephalitis Viruses

Dengue and Psychiatry: Manifestations, Mechanisms, and Management Options

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