This study aimed to investigate the effect of curcumin and/or anise seeds supplementation on the performance, immunological parameters and the bioavailability of calcium, phosphorus and nitrogen of Japanese quail fed graded levels of curcumin (0, 100 and 200 mg/kg feed) and ground anise seeds (0, 1%) during a 42-day feeding trial. 162 (one hundred sixty two), one-day-old quail chicks were assigned in factorial design (3×2). The results clearly that curcumin or anise seeds did not have a significant effect on body weight (BW) and body weight gain (BWG). Anise seeds supplementation improved feed conversion ratio (FCR) during the period from 3-6 wks of age. Quails fed curcumin at level of 200 mg/kg plus 1% ground anise seeds achieved significantly (P<0.05) higher feed conversion ratio (FCR) during the first 3 wks of age. Curcumin groups exhibited highly significant relative weight of spleen and bursa of fabricius , IgA, IgM, and IgG compared to the control group. Birds fed diets containing curcumin at level of 200 mg/kg and 1% anise seeds had numerically higher calcium and nitrogen bioavailability. Phosphorus bioavailability was significantly (P<0.05) higher in birds fed 200 mg/kg curcumin and 1% anise seeds. It was recommended that curcumin should be add at level of 200 mg/kg diet or with 1% anise ground seeds to achieve the best results of growth performance, immunological parameters and the bioavailability of calcium, phosphorus and nitrogen.