Behavior Modification in Groups

Sundel, Martin; Sundel, Sandra Stone

doi:10.1007/978-1-4684-4958-7_1

Cited by 5 publications

(1 citation statement)

References 4 publications

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“…IVIG‐resistant KD was defined as any of the following: (1) Persistent fever of any magnitude 24–36 h after completion of initial IVIG therapy, (2) Return of fever of any magnitude after an afebrile period not explained by any cause other than KD (up to 2 weeks after the start of treatment) and (3) Other signs of failed initial therapy, such as progressive coronary artery dilation or other manifestations of inflammation associated with KD. 29 …”

Section: Methodsmentioning

confidence: 99%

CD14 down‐modulation as a real‐time biomarker in Kawasaki disease

Inada,

Sonoda,

Mizuno

et al. 2023

Clin & Trans Imm

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ObjectivesThe objectives of this study were to investigate the pathophysiology of Kawasaki disease (KD) from immunological and oxidative stress perspectives, and to identify real‐time biomarkers linked to innate immunity and oxidative stress in KD.MethodsWe prospectively enrolled 85 patients with KD and 135 patients with diverse conditions including immune, infectious and non‐infectious diseases for this investigation. Flow cytometry was used to analyse the surface expression of CD14, CD38 and CD62L on monocytes, along with a quantitative assessment of CD14 down‐modulation. Additionally, oxidative stress levels were evaluated using derivatives of reactive oxygen metabolites (d‐ROMs) and antioxidant capacity measured by a free radical elective evaluator system.ResultsDuring the acute phase of KD, we observed a prominent CD14 down‐modulation on monocytes, reflecting the indirect detection of circulating innate immune molecular patterns. Moreover, patients with KD showed a significantly higher CD14 down‐modulation compared with infectious and non‐infectious disease controls. Notably, the surface expression of CD14 on monocytes was restored concurrently with responses to intravenous immunoglobulin and infliximab treatment in KD. Furthermore, d‐ROM levels in patients with KD were significantly elevated compared with patients with infectious and non‐infectious diseases. Following intravenous immunoglobulin treatment, oxidative stress levels decreased in patients with KD.ConclusionMonitoring CD14 down‐modulation on monocytes in real‐time is a valuable strategy for assessing treatment response, distinguishing KD relapse from concomitant infections and selecting second‐line therapy after IVIG treatment in KD patients. The interplay between inflammation and oxidative stress likely plays a crucial role in the development of KD.

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Section: Methodsmentioning

confidence: 99%

CD14 down‐modulation as a real‐time biomarker in Kawasaki disease

Inada,

Sonoda,

Mizuno

et al. 2023

Clin & Trans Imm

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Teaching evolutionary biology: Pressures, stress, and coping

2004

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Understanding what teachers need to be more comfortable and confident in their profession is crucial to the future of effective teachers and scientific literacy in public schools. This study focuses on the experiences of Arizona biology teachers in teaching evolution, using a clinical model of stress to identify sources of pressure, the resulting stresses, and coping strategies they employ to alleviate these stresses. We conducted focus groups, one‐on‐one interviews, and written surveys with 15 biology teachers from the Phoenix area. On the basis of their responses, teachers were clustered into three categories: “Conflicted,” who struggle with their own beliefs and the possible impact of their teaching, “Selective,” who carefully avoid difficult topics and situations, and “Scientists,” who see no place for controversial social issues in their science classroom. Teachers from each group felt that they could be more effective in teaching evolution if they possessed the most up‐to‐date information about evolution and genomics, a safe space in which to reflect on the possible social and personal implications with their peers, and access to richer lesson plans for teaching evolution that include not only science but personal stories regarding how the lessons arose, and what problems and opportunities they created. © 2004 Wiley Periodicals, Inc. J Res Sci Teach 41: 791–809, 2004

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Selbsterfahrung und Eigentherapie

Laireiter

Fiedler

1996

Selbsterfahrung in Der Verhaltenstherapie?

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Behavior Modification in Groups

Cited by 5 publications

References 4 publications

CD14 down‐modulation as a real‐time biomarker in Kawasaki disease

CD14 down‐modulation as a real‐time biomarker in Kawasaki disease

Teaching evolutionary biology: Pressures, stress, and coping

Selbsterfahrung und Eigentherapie

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