Behavior of Antibacterial Ofloxacin; Hydronation Constants and Solubility in Aqueous Solutions of Sodium Chloride at Different Temperatures

Identification of Dual Inhibitors Targeting Main Protease (Mpro) and Cathepsin L as Potential Anti-SARS-CoV-2 Agents

“…In the context of anti-SARS-CoV-2 agents, nirmatrelvir showed a very low solubility in pure water . The structure of the drug-candidate 4d does not show ionizable groups; therefore, its solubility ( S T ) corresponds only to the concentration of the neutral species ( S 0 = c 4d ) . In this light, the 4d S T , expressed in mM concentration scale, was determined in water at T = 37.0 ± 0.1 °C by UV–vis spectrophotometry after sonication. , The calibration straight line obtained by measuring the absorbance signal at a fixed wavelength λ = 226 nm of five standard solutions prepared in the range of c 4d = 0.013–0.064 mM was used for the determination of the 4d solubility.…”