Behavior of multisubstituted hydroxyapatites in water and simulated body fluid

Abstract

Nanostructured hydroxyapatite (HAP) and three multiple substituted HAPs, containing Mg, Zn, Sr and Si were synthesized by a wet precipitation method The presence of the HAP lattice as unique crystalline phase was established by XRD and by FTIR spectroscopy. The chemical composition was confirmed by SEM-EDX. The TEM, SEM and AFM imaging showed the morphology of these biomaterials. The elements release in water and in simulated body fluid (SBF) was monitored in time from 1 to 90 days, by using inductively coupled plasma optical emission spectrometry (ICP-OES). The results are important for the future use of these hydroxyapatite biomaterials, as bone substitutes or coatings on metallic implants, able to release essential physiological elements, both in vitro and in vivo, with great impact in orthopedics and dentistry.

"Innovative chemical coating protocol for Titanium alloy implants "

“…The surface structure of coated implants suffers changes of greater corrosion resistance and also in apatite formation due to the occurrence of passive oxide layer [26]. Future studies should be done to investigate the osteoblasts and osteocytes adhesion on coating materials such as HA or TiO 2 , as well as the possibility to create osteoclastic inhibition [27,28].…”

Silymarin Based Complexes – a mini review

“…The substituted elements can lead to beneficial effects on morphology, structure and mechanical properties. HAP can be used in bone tissue engineering, implant coating, dental materials and drug carriers [50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67].…”

Biomimetic and Antibacterial Composite for Orthopedic Implants

“…The final precipitate was filtered and washed repeatedly with ultrapure water at room temperature until nitrates were removed. The drying process was performed by lyophilization followed by the calcination step at 300°C for one hour and the sample was disintegrated in a ball mill to obtain a fine powder [70][71][72][73].…”

“…A release of ions into water can be observed (Figure 3), for substituted hydroxyapatites, the amount of Ca released is higher than from pure HAP and very similar for all complex hydroxyapatites [71][72][73][74][75][76][77][78][79][80][81]. Multisubstituted hydroxyapatites with a long release of ions could be used as resorbable fillers for bone defects or even as coatings, as these particles could release ions for a longer period of time which can be beneficial for the formation of new bones.…”