Behavior of the Amphiphile CHAPS Alone and in Combination with the Biopolymer Inulin in Water and Isopropanol–Water Media

Naskar, Bappaditya; Ghosh, Soumen; Nagadome, Shigemi; Sugihara, Ghosuke; Moulik, Satya P.

doi:10.1021/la201119c

Cited by 28 publications

(17 citation statements)

References 88 publications

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“…However, spherical morphologies found in the SEM measurement support the assumption made in the DLS studies. Such distinct size variations between a microscopic technique and light‐scattering measurement were earlier observed for various self‐assembled systems in non‐polar, as well as in aqueous media ,…”

Section: Resultssupporting

confidence: 61%

Study on the Conformation of Entrapped Protein inside the Reverse Micellar Confinement Based on the Amino Acid Derived Ionic Liquid

et al. 2018

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Owing to superior surface‐activity and versatility in functionalization compared to conventional surfactants, surface‐active ionic liquids (SAILs) gained immense interest in recent years. Toxicity and biodegradation remain central issues while dealing with the SAILs and thus, the quest for synthesis of greener SAILs is increasing day by day. Keeping in view of the importance of SAIL's performance, we undertook the present study for the formulation of reverse micelles (RMs) using biodegradable L‐proline propyl ester lauryl sulfate ([ProC3][LS]) in cyclohexane (Cy). The formation of RMs was confirmed from the phase behavior and dynamic light scattering (DLS) studies. Fourier‐transform infrared spectroscopy (FTIR) study revealed the solvation of anionic head group through H‐bonding by added water. An increased micropolarity and reduced microviscosity were evidenced inside the RM droplets as a function of hydration level. Finally, the encapsulation of BSA protein in RMs was investigated through the fluorescence, circular dichroism and DLS studies, which showed conformation with higher degree of secondary structural content than the native state inside the droplet core at higher hydration. Our results signify the importance of the role of hydration in the function of enzyme or protein molecules in molecular crowding environments. These facts certainly prove the versatility of this kind of organized assemblies to alter their inherent properties simply by changing water content.

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Section: Resultssupporting

confidence: 61%

Study on the Conformation of Entrapped Protein inside the Reverse Micellar Confinement Based on the Amino Acid Derived Ionic Liquid

et al. 2018

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“…[2][3][4][5]. Their interaction with polymers (including biopolymers) itself is a very promising and important field of research from the stand point of application [6,7]. The above microheterogeneous systems are promising with regard to their use as templates for the synthesis of nanostructured materials [8,9].…”

Section: Introductionmentioning

confidence: 99%

Counter‐ion Effect on Micellization of Ionic Surfactants: A Comprehensive Understanding with Two Representatives, Sodium Dodecyl Sulfate (SDS) and Dodecyltrimethylammonium Bromide (DTAB)

Naskar

Dey

Moulik

2013

J Surfact & Detergents

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Various micelle parameters viz., critical micelle concentration (CMC), counter-ion binding (b), aggregation number (N), hydrodynamic radius (R h ), micelle zeta potential (f) and energetic parameters, free energy of micellization (DG 0 m ), enthalpy of micellization (DH 0 m ) and entropy of micelle formation (DS 0 m ) were determined for sodium dodecylsulfate, and dodecyltrimethylammonium bromide in the presence of NaCl for the former and NaBr for the latter. Conductometry and calorimetry methods were used for the measurements of CMC and energetic parameters. The fluorimetric (static quenching) method was employed to determine N and dynamic light scattering to estimate R h and f. The conductometrically determined b was verified from the CMC values by calorimetry using the Corrin-Harkins equation. The results found for the two surfactants of identical tails but different head groups have been presented and discussed. A detailed report on the salt effect using salts containing counter-ions the same as those in the surfactant is found only limitedly in the literature.

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“…The outer and inner coats were intended to provide protection against gastric and intestinal environments, respectively. The drug was then released in the colon with the degradation of the other two polysaccharides 29,30 .…”

Section: Controlled and Targeted Drug Release By Inulin Complexesmentioning

confidence: 99%

Inulin: A promising carrier for controlled and targeted drug delivery system

Akram

Joshi

Garud

2019

J. Drug Delivery Ther.

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The delivery of a drug to the preferred site of action is referred to as drug targeting. The benefits of drug targeting are a reproducible and controlled release rate of the therapeutic compound, which forestalls overdose. Due to the potential to treat colonic diseases with minimum side effects, colon targeting has become of high interest over the last decades. Inulin was investigated for its potential as encapsulation material regarding its enzymatic degradability and its drug release behaviour. Inulin is a polysaccharide with a widespread range of therapeutic uses such as a carrier in a drug delivery vehicle, as a diagnostic/analytical tool or as a dietary fibre with additional health benefits. In the main, much research has focused on inulin as a drug delivery carrier for colon-specific drug delivery. The justification for this is its potential to survive in the stomach’s acidic environment. This unique stability and strength are utilized in many ways to deliver drugs safely to the colon, where they can be easily absorbed through the gut epithelium into the blood. There are also some proofs that inulin’s prebiotic features also lead to health benefits, mainly for patients with inflammatory bowel disease or in the prevention of colonic cancer. Inulin based hydrodynamic research will be useful to discover the potential of inulin.

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Behavior of the Amphiphile CHAPS Alone and in Combination with the Biopolymer Inulin in Water and Isopropanol–Water Media

Cited by 28 publications

References 88 publications

Study on the Conformation of Entrapped Protein inside the Reverse Micellar Confinement Based on the Amino Acid Derived Ionic Liquid

Study on the Conformation of Entrapped Protein inside the Reverse Micellar Confinement Based on the Amino Acid Derived Ionic Liquid

Counter‐ion Effect on Micellization of Ionic Surfactants: A Comprehensive Understanding with Two Representatives, Sodium Dodecyl Sulfate (SDS) and Dodecyltrimethylammonium Bromide (DTAB)

Inulin: A promising carrier for controlled and targeted drug delivery system

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