Behavior of the Leukocytes of the Rabbit During Periods of Transient Leukopenia Variously Induced

Essex, Hiram E.; Grana, A

doi:10.1152/ajplegacy.1949.158.3.396

Cited by 17 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is evidence that the leucopenia is merely a reflection of sudden sequestration of leucocytes at a variety of intravascular sites (27,53). In fact, a number of workers (28,29) have observed by direct microscopy that, following the injection of certain pyrogens, leucocytes are immobilized in small vessels in which they appear to "stick" to the endothelium. I~ It is possible that leucocytes thus immobilized may provide the principal source of the endogenous pyrogen, which in turn may be responsible for the fever (9).…”

Section: Discussionmentioning

confidence: 99%

“…First, through its well known anti-inflammatory action (21)(22)(23)(24)(25)(26) it may interfere with the prefever leucopenia, which is said to result from an intravascular inflammatory response involving the "sticking" of leucocytes to vascular endothelium (27)(28)(29)(30). Secondly, it may alter the composition of the recipient's serum in such a way as to modify the effect of the serum factor upon which the action of the injected pyrogen appears to depend.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Studies on the Antipyretic Action of Cortisone in Pyrogen-Induced Fever

Atkins

Allison

Smith

et al. 1955

The Journal of Experimental Medicine

View full text Add to dashboard Cite

The mode of action of cortisone as an antipyretic has been studied in rabbits challenged with intravenous injections of bacterial pyrogens. The fever induced by pyromen or dextran was found to be markedly suppressed when cortisone was administered in liberal amounts (25 mg. twice daily) for 3 days prior to the challenge. Although the cortisone effectively blocked the febrile response to both pyrogens, it failed to influence the transient but marked leucopenia which characteristically precedes the onset of fever. The antipyretic action of the drug also was shown to bear no relation to the activity of the serum factor recently demonstrated by Farr, Grant, and others to be involved in the production of pyrogen-induced fever. In preliminary experiments with typhoid vaccine as the inciting pyrogen, the presence of serum factor activity in normal blood and its absence in the blood of pyrogen-tolerant rabbits was confirmed. Subsequently the blood of rabbits treated with antipyretically effective doses of cortisone was shown to contain just as much serum factor activity as that of normal rabbits. In addition, previous incubation of the pyrogen with serum factor failed to influence the antipyretic effect of the drug. It is concluded from these findings that in suppressing pyrogen fever, cortisone acts neither upon the leucopenic reaction nor upon the fever-accelerating factor of the serum. By exclusion it would appear that the drug must influence some later stage of the fever-producing process. The mechanisms involved in the later stages of the response to exogenous pyrogen remain undefined, and the need for determining whether they are related to the prefebrile leucopenia is emphasized.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Studies on the Antipyretic Action of Cortisone in Pyrogen-Induced Fever

Atkins

Allison

Smith

et al. 1955

The Journal of Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…Toxicity was defined as being manifested by any of the following: gross bleeding, platelet level below 75,000 per cubic millimeter, the appearance of ecchymosis or petechiae, prothrombin time greater than 40 seconds, clotting time greater than three times the control value, diarrhea, hypotension, disorientation, or psychOSiS. These changes called for immediate interruption of polyethylene sulfonate administration.…”

Section: Methodsmentioning

confidence: 99%

“…Dextran sulfate, a heparinoid similar to polyethylene sulfonate, can produce anaphylactoid responses in animals. 137 Shock induced by polyethylene sulfonate differs from that of anaphylaxis 40 108,109 in that there is no consistent evidence of acute thrombocytopenia induced by the drug. When endotoxin is administered to patients, in addition to the symptoms seen in anaphylaxis, it invariably produces a shaking chill and fever which precede the onset of hypotension.…”

Section: Clinical Pharmacologymentioning

confidence: 99%

Effect of an anionic polyelectrolyte (polyethylene sulfonate) in patients with cancer Clinical pharmacology of a macromolecule

Regelson

Holland

1962

Clin Pharma and Therapeutics

View full text Add to dashboard Cite

Polyethylene sulfonate, an anionic polymer of average molecular weight (13,000) Department of Medicine A, Roswell Park Memorial InstituteThe anionic polyelectrolyte polyethylene sulfonate, in the form of the sodium salt of polymeric ethylene sulfonic acid, has been shown by us to be an active inhibitor of seven transplanted solid tumors in mice. 103 ,105 Polyethylene sulfonate, of an average molecular weight of 13,000, has been reported to be a less potent anticoagulant than native heparin but to have similar lipolytic activity. 26,37,38,42,73 Like heparin, polyethylene sulfonate showed no bone marrow depression on chronic administration to animals but produced pathologic fracture as well as evidence of ulceration of the gastrointestinal tract.26 Earlier clinical study of its lipolytic activity in man was uneventful. 37, 38, 73 Because of its tumor-inhibiting activity in mice, a trial against advanced cancer in man was undertaken.

show abstract

Vascular changes in the cheek pouch of the golden hamster during infection with Trichinella spiralis larvae

Humes

Akers

1952

Anat. Rec.

View full text Add to dashboard Cite

Iiicreasecl vascularity in tlie immediate vicinity of muscle fibers infected with Trichivzelln spiralis larvae has been observed in post-mortem studies. Pagensteclier (1865) observed the extraordinary developnient of the mesh of blood vessels around infected muscle fibers before the beginning of encapsul'ation and published a drawing of such a vascular netmorlc. Ogielslii ('49), after a post-mortem injection of China ink in mice, sliomed a ''netting of capillaries" around the site of each larva in the muscle fibers. He observed no vascular networks through the 22nd day after infection, but a t 33 days iietmorks of vessels were present around the coiled l a i~a e . After 46 days, the muscle striations began to disappear, and the site of each larva bccanie distinct and sharply limited from the surrounding area. He suggested that one of the reasons why the larvae settle mostly in certain places, for example, the diaphragm, inay be that these muscles have a large number of richly ramified vessels.Because of the hemostasis which occurs after death, it is virtually impossible to distinguish vessels of capillary size in freshly pressed muscle mitliout previous injection of colored 'This iiivestigatioii n n s supported (in part)

show abstract

Behavior of the Leukocytes of the Rabbit During Periods of Transient Leukopenia Variously Induced

Cited by 17 publications

References 0 publications

Studies on the Antipyretic Action of Cortisone in Pyrogen-Induced Fever

Studies on the Antipyretic Action of Cortisone in Pyrogen-Induced Fever

Effect of an anionic polyelectrolyte (polyethylene sulfonate) in patients with cancer Clinical pharmacology of a macromolecule

Vascular changes in the cheek pouch of the golden hamster during infection with Trichinella spiralis larvae

Contact Info

Product

Resources

About