Behavior of the Roman/Verh high- and low-avoidance rat lines in anxiety tests: relationship with defecation and self-grooming

Ferré, Pilar; Fernández-Teruel, Alberto; Escorihuela, Rosa M.; Driscoll, Peter; Corda, Maria Giuseppa; Giorgi, Osvaldo; Tobeña, Adolf

doi:10.1016/0031-9384(95)02068-3

Cited by 101 publications

(38 citation statements)

References 29 publications

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“…Interestingly, chronically stressed fathers in the same study had increased levels of AVP mRNA in the paraventricular nucleus of the hypothalamus (PVN) compared to nonstressed fathers and also showed higher levels of autogrooming following stress. Both PVN expression of AVP and autogrooming are linked to anxiety in rodents (Ferré et al 1995), suggesting that anxiety, as well as stress, might inhibit paternal behavior.…”

Section: Stress and Anxietymentioning

confidence: 99%

Paternal Care in Biparental Rodents: Intra- and Inter-individual Variation

Saltzman

Harris

Jong

et al. 2017

Integrative and Comparative Biology

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Section: Stress and Anxietymentioning

confidence: 99%

Paternal Care in Biparental Rodents: Intra- and Inter-individual Variation

Saltzman

Harris

Jong

et al. 2017

Integrative and Comparative Biology

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“…They were bred at the Autonomous University of Barcelona (Spain) from colonies established in 1997 (Driscoll et al, 1998;Escorihuela et al, 1997Escorihuela et al, , 1999. Although the literature refers to gender differences in the expression of impulsive behavior, we used female rats in the present experiments because the behavioral traits that distinguish the Roman lines have been consistently confirmed in both sexes across several laboratories and along different generations (Aguilar et al, 2003;Corda et al, 2005;Ferre et al, 1995;Rosas et al, 2007).…”

Section: Animalsmentioning

confidence: 99%

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Moreno

Cardona

Gómez

et al. 2010

Neuropsychopharmacol

134

106

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The selective breeding of Roman high-(RHA) and low-avoidance (RLA) rats for rapid vs extremely poor acquisition of active avoidance behavior in a shuttle-box has generated two phenotypes with different emotional and motivational profiles. The phenotypic traits of the Roman rat lines/strains (outbred or inbred, respectively) include differences in sensation/novelty seeking, anxiety/fearfulness, stress responsivity, and susceptibility to addictive substances. We designed this study to characterize differences between the inbred RHA-I and RLA-I strains in the impulsivity trait by evaluating different aspects of the multifaceted nature of impulsive behaviors using two different models of impulsivity, the delay-discounting task and five-choice serial reaction time (5-CSRT) task. Previously, rats were evaluated on a schedule-induced polydipsia (SIP) task that has been suggested as a model of obsessive-compulsive disorder. RHA-I rats showed an increased acquisition of the SIP task, higher choice impulsivity in the delay-discounting task, and poor inhibitory control as shown by increased premature responses in the 5-CSRT task. Therefore, RHA-I rats manifested an increased impulsivity phenotype compared with RLA-I rats. Moreover, these differences in impulsivity were associated with basal neurochemical differences in striatum and nucleus accumbens monoamines found between the two strains. These findings characterize the Roman rat strains as a valid model for studying the different aspects of impulsive behavior and for analyzing the mechanisms involved in individual predisposition to impulsivity and its related psychopathologies.

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“…Thus, during avoidance training, RLA rats display a behavioral repertoire characterized mainly by hypomotility and freezing, whereas the less emotional RHA rats display an active coping behavior that leads to the rapid acquisition of the avoidance response (Escorihuela et al 1995a). Accordingly, RLA rats are more emotional/fearful than RHA rats in most conditioned and unconditioned anxiety-related tasks, and display a more passive coping strategy than RHA rats when facing intensely stressful situations (Aguilar et al 2002;Driscoll et al 1998;Escorihuela et al 1999;Fernández-Teruel et al 2002b;Ferré et al 1995;Steimer and Driscoll 2003).…”

Section: Introductionmentioning

confidence: 99%

“…It is noteworthy that, whereas the behavior of the Roman lines has been evaluated in detail in several anxiety tests (Ferré et al 1995;Fernández-Teruel et al 2002b;López-Aumatell et al 2009), the characterization of the behavioral profile of these lines in tests that model some facets of depression is long overdue.…”

Section: Introductionmentioning

confidence: 99%

Effects of antidepressants on the performance in the forced swim test of two psychogenetically selected lines of rats that differ in coping strategies to aversive conditions

2010

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RLA and RHA rats represent two divergent phenotypes respectively susceptible and resistant to display depression-like behavior in the forced swim test. Hence, comparative studies in these lines may help to develop novel working hypotheses on the relationships among genotype, temperament traits, and neural mechanisms underlying the vulnerability or resistance to stress-induced depression in humans.

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Behavior of the Roman/Verh high- and low-avoidance rat lines in anxiety tests: relationship with defecation and self-grooming

Cited by 101 publications

References 29 publications

Paternal Care in Biparental Rodents: Intra- and Inter-individual Variation

Paternal Care in Biparental Rodents: Intra- and Inter-individual Variation

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Effects of antidepressants on the performance in the forced swim test of two psychogenetically selected lines of rats that differ in coping strategies to aversive conditions

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