Behavioral alterations due to diesel exhaust exposure

Laurie, R D; Boyes, William K.; Wessendarp, T.

doi:10.1016/0160-4120(81)90082-9

Cited by 6 publications

(3 citation statements)

References 2 publications

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“…If our observation of decreased locomotion in the open field extends to home‐cage behaviour, our results indicate that the particulates in diesel exhaust may at least have contributed to the effects reported by Laurie et al. [15]. One possible explanation is that diesel exhaust particles could have affected lung function and thereby reducing the animals’ propensity towards physical activity.…”

Section: Body Weight During Study Periodsupporting

confidence: 63%

“…We have not located any studies evaluating effects of particulate diesel matter in adult animals on cognitive function, but rats have presented with decreased activity in home-cage running wheels during long-term exposure to whole diesel exhaust [14,15]. If our observation of decreased locomotion in the open field extends to home-cage behaviour, our results indicate that the particulates in diesel exhaust may at least have contributed to the effects reported by Laurie et al [15]. One possible explanation is that diesel exhaust particles could have affected lung function and thereby reducing the animals' propensity towards physical activity.…”

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confidence: 99%

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Diesel Exhaust Particles: Effects on Neurofunction in Female Mice

Hougaard

Saber

Jensen

et al. 2009

Basic Clin Pharma Tox

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Section: Body Weight During Study Periodsupporting

confidence: 63%

mentioning

confidence: 99%

Diesel Exhaust Particles: Effects on Neurofunction in Female Mice

Hougaard

Saber

Jensen

et al. 2009

Basic Clin Pharma Tox

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“…Although the effect was not statistically significant, it suggests that DEE could cause motor impairments in other mouse strains. Indeed, others have shown locomotive activity effects in rats following exposure to DEE (6 mg/m 3 , 8 h/day for 16 weeks) [ 53 ] or mice exposed to resuspended diesel exhaust particles (72 mg/m 3 , 90 min/day for 4 days) [ 54 ]. Interestingly, decreased locomotor activity has also been shown in mice following prenatal exposure [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer’s disease

et al. 2017

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BackgroundIncreasing evidence from toxicological and epidemiological studies indicates that the central nervous system is an important target for ambient air pollutants. We have investigated whether long-term inhalation exposure to diesel engine exhaust (DEE), a dominant contributor to particulate air pollution in urban environments, can aggravate Alzheimer’s Disease (AD)-like effects in female 5X Familial AD (5XFAD) mice and their wild-type female littermates. Following 3 and 13 weeks exposures to diluted DEE (0.95 mg/m3, 6 h/day, 5 days/week) or clean air (controls) behaviour tests were performed and amyloid-β (Aβ) plaque formation, pulmonary histopathology and systemic inflammation were evaluated.ResultsIn a string suspension task, assessing for grip strength and motor coordination, 13 weeks exposed 5XFAD mice performed significantly less than the 5XFAD controls. Spatial working memory deficits, assessed by Y-maze and X-maze tasks, were not observed in association with the DEE exposures. Brains of the 3 weeks DEE-exposed 5XFAD mice showed significantly higher cortical Aβ plaque load and higher whole brain homogenate Aβ42 levels than the clean air-exposed 5XFAD littermate controls. After the 13 weeks exposures, with increasing age and progression of the AD-phenotype of the 5XFAD mice, DEE-related differences in amyloid pathology were no longer present. Immunohistochemical evaluation of lungs of the mice revealed no obvious genetic background-related differences in tissue structure, and the DEE exposure did not cause histopathological changes in the mice of both backgrounds. Luminex analysis of plasma cytokines demonstrated absence of sustained systemic inflammation upon DEE exposure.ConclusionsInhalation exposure to DEE causes accelerated plaque formation and motor function impairment in 5XFAD transgenic mice. Our study provides further support that the brain is a relevant target for the effects of inhaled DEE and suggests that long-term exposure to this ubiquitous air pollution mixture may promote the development of Alzheimer’s disease.

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Neurophysiological alterations due to diesel exhaust exposure during the neonatal life of the rat

Laurie

Boyes

1981

Environment International

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Behavioral alterations due to diesel exhaust exposure

Cited by 6 publications

References 2 publications

Diesel Exhaust Particles: Effects on Neurofunction in Female Mice

Diesel Exhaust Particles: Effects on Neurofunction in Female Mice

Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer’s disease

Neurophysiological alterations due to diesel exhaust exposure during the neonatal life of the rat

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