Behavioral analysis of amygdaloid kindling in beagle dogs and the effects of clonazepam, diazepam, phenobarbital, diphenylhydantoin, and flunarizine on seizure manifestation

Wauquier, A.; Ashton, David; Melis, W.

doi:10.1016/0014-4886(79)90233-4

Cited by 78 publications

(24 citation statements)

References 7 publications

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“…The spontaneous seizures in kindled animals are not just a rat phenomenon, but have been reported also in cats, dogs and primates (32,111,113). Further, because not all members in a kindled group of animals develop spontaneous convulsive seizures (72,84), it begs the question as to whether there is a genetic predisposition for development of those responses.…”

Section: Kindling (Dr D C Mcintyre)mentioning

confidence: 99%

Animal Models of Limbic Epilepsies: What Can They Tell Us?

2002

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Section: Kindling (Dr D C Mcintyre)mentioning

confidence: 99%

Animal Models of Limbic Epilepsies: What Can They Tell Us?

2002

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“…Kindled seizures were induced in rats, cats, monkeys, dogs, rabbits, and frogs (Goddard, 1967;Goddard et al, 1969;Wada and Sato, 1974;Morrell and Tsuru, 1976;Stach et al, 1978;Wauquier et al, 1979). This means that the kindling phenomenon is not limited to one or two species of animals, but rather seems to reflect a general characteristic of brain action.…”

mentioning

confidence: 99%

Development and Persistence of Kindled Seizures After Repeated Injections of Pentylenetetrazol in Rats and Guinea Pigs

1984

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Pentylenetetrazol (PTZ) was injected into rats (30 or 35 mg/kg) and guinea pigs (40 or 45 mg/kg) daily or every second day. A progressive development of seizure activity after this treatment was observed. Doses ineffective after the first injection induced tonic seizures after 20 injections. Both kinds of treated animals immediately developed tonic seizures when PTZ was injected after a few months interruption for one time only. The results support the assumption that seizures induced by chronic injection of PTZ are similar to kindled seizures evoked by daily electrical stimulation and can be regarded as a model of epileptogenesis.

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“…38,128 This event sets up an electrical circuitry that can ultimately initiate a seizure spontaneously. 38,128 This event sets up an electrical circuitry that can ultimately initiate a seizure spontaneously.…”

Section: Treatmentmentioning

confidence: 99%