1986
DOI: 10.1007/bf00174376
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Behavioral and biochemical studies of dopamine receptor sensitivity in differentially housed mice

Abstract: Group housed and individually housed mice were compared in (1) the motor activity responses to direct and indirect dopamine (DA) agonists, (2) in vivo presynaptic autoreceptor sensitivity and (3) in vitro binding of 3H-spiperone. Relative to group housed mice, individually housed mice showed an increased motor activity response to amphetamine, 1.25 and 0.625 mg/kg. Using two in vivo measures of presynaptic DA receptor sensitivity, the antagonism of spontaneous locomotor activity and the antagonism of dihydroxy… Show more

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Cited by 28 publications
(12 citation statements)
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“…Second, we observed a clear potentiation of the amphetamine hyperlocomotor response in male mice that is in agreement with previous mouse studies (Wilmot et al 1984(Wilmot et al , 1986. These findings in mice contrasted with the failure to obtain such an effect in Sprague-Dawley rats by Weiss et al (2001a).…”
Section: Discussionsupporting
confidence: 86%
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“…Second, we observed a clear potentiation of the amphetamine hyperlocomotor response in male mice that is in agreement with previous mouse studies (Wilmot et al 1984(Wilmot et al , 1986. These findings in mice contrasted with the failure to obtain such an effect in Sprague-Dawley rats by Weiss et al (2001a).…”
Section: Discussionsupporting
confidence: 86%
“…These findings are indicative of mesolimbic hyperdopaminergia (Dai et al 2004;Heidbreder et al 2000;Jones et al 1990;Leng et al 2004;Wilmot et al 1986), which is closely related to the genesis of positive symptoms in schizophrenia (e.g., Gray et al 1991;Laruelle et al 1999). …”
Section: Introductionmentioning
confidence: 93%
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“…In our stress model, concentrations of plasma corticosterone in isolated mice were significantly increased compared to control levels. Social isolation stress, caused by abolished social interaction among animals, has been reported to induce behavioural changes as a result of elevated levels of circulating corticosterone (Stranahan et al 2006) in rats and mice ; increased locomotor activity in a novel environment (Guo et al 2004 ;Lapiz et al 2003 ;Wilmot et al 1986), increased anxiety in an elevated plus-maze (Molina-Hernandez et al 2001), increased depressive-like behaviour in the forced swimming test (Brenes & Fornaguera, 2008), and impaired learning and memory in the one-trial passive avoidance test (Chida et al 2006). Further, social isolation for 6 h/d during PD 15-21 was sufficient to cause an acute elevation of corticosterone levels, leading to an impairment of performance in the Morris water maze task when animals were tested on PD 22-24 (Frisone et al 2002).…”
Section: Discussionmentioning
confidence: 99%
“…There are pharmacological and neurochemical studies supporting this hypothesis. Compared to animals that had been reared in social groups, isolated animals have been generally characterized by enhanced sensitivity to the stimulant effects of d-amphetamine, apomorphine, or cocaine (Ahmed, Stinus, Le Moal, & Cador, 1995;Jones et al, 1990;Lewis et al, 1990;Phillips et al, 1994;Wilmot, Vanderwende, & Spoerlein, 1986). Although some studies did not report this effect (Bowling & Bardo, 1994;Hall, Fong, Ghaed, & Pert, 2001;Jones, Hernandez, Kendall, Marsden, & Robbins, 1992;Weiss, Domeney, Heidbreder, Moreau, & Feldon, 2001), these observations Paul L. Gendreau and Mark H. Lewis suggest that social deprivation heightens social-emotional reactivity by means of alterations in DA sensitivity.…”
Section: Dopamine Function In Socially and Maternally Deprived Animalsmentioning
confidence: 99%