Behavioral and personality features in patients with lateralized Parkinson’s disease

Abstract

This study suggests that side dominance of dopaminergic denervation may be related to personality features in patients with PD that could influence behavioral aspects.

Parkinson's disease with a predominant right-sided putaminal FP-CIT SPECT deficiency shows stronger decline of asymmetry over time

“…The relevance of this laterality is corroborated by further observations: first, by the higher predominance of right-sided symptoms in PD, compared to leftsided ones [12]. And secondly, as several non-motor symptoms including cognitive decline [13], hypomania [14] or anosognosia [15] have a distinct prevalence depending upon the side in which PD-symptoms manifest first. Probably, this reflects distinct affection of the two hemispheres.…”

Disease-associated differences in religious cognition in patients with Parkinson's disease

“…For statistical analysis we also used the Asymmetry subscale of the UPDRS, which indicates the degree of right-versus left-sided motor severity. The decision to use UPDRS asymmetry scores as a proxy for right/left forebrain dysfunction is supported by several reports that demonstrate neurobehavioral differences in rightversus left-onset PD patients (Katzen, Levin, & Weiner, 2006;Piacentini, Versaci, Romito, Ferre, & Albanese, 2011;Tomer & Aharon-Peretz, 2004;Tomer, AharonPeretz, & Tsitrinbaum, 2007;Tomer, Levin, & Weiner, 1993). Specifically, left-onset PD patients are allegedly more vulnerable to change in personality features, executive, and frontostriatal dysfunction.…”

Personality traits in patients with Parkinson’s disease: assessment and clinical implications

“…A study [9] adopting the 16 Personality Factors [48] reported that PD patients tested as more socially alert, tense, apprehensive, driven, self-reproaching, cautious, restless and sceptical compared to HC. Two studies [49,50] adopted the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) [51]. In the first study [49] PD patients reported higher scores than HC on Depression, Hysteria, Hypochondriasis and Social Introversion, and in the second study [50] left-lateralized PD patients had higher score in the Hypomania scale relative to right-lateralized PD patients.…”

“…Two studies [49,50] adopted the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) [51]. In the first study [49] PD patients reported higher scores than HC on Depression, Hysteria, Hypochondriasis and Social Introversion, and in the second study [50] left-lateralized PD patients had higher score in the Hypomania scale relative to right-lateralized PD patients. A study [51] adopting the Brooks & McKinlay Personality Inventory [52] reported that PD patients tested as less talkative and flexible and more cautious, generous and even-tempered compared to HC.…”