Behavioral and psychological symptoms, cognitive impairment and caregiver burden related to Alzheimer's disease patients treated in an outpatient memory clinic

Takechi, Hajime; Yamada, Hiroko; Sugihara, Yuriko; Kita, Toru

doi:10.3143/geriatrics.43.207

Cited by 7 publications

(6 citation statements)

References 29 publications

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“…In addition, there were no significant differences in neuropsychological cognitive sub-scales of COGNISTAT scores between the two groups. These results confirm the results of previous studies concerning the relations between delusion and neuropsychological cognitive functions (Burns et al, 1990;Ikeda, 2004;Migliorelli et al, 1995;Takechi et al, 2006). Social cognitive functions construct representations of relationships between oneself and others, and cannot be generally assessed by neuropsychological cognitive tests (Adolphs, 2001).…”

Section: Discussionsupporting

confidence: 89%

“…Ikeda (2004) reported that there were no significant differences in sub-scale scores on the Alzheimer's disease Assessment Scale (ADAS) between AD patients with and without delusion of theft. Takechi et al (2006) reported that there were no significant differences in scores on the word fluency test, category cued memory test and clock drawing test between AD patients with and without delusion of theft, although there was a significant difference in their MMSE scores. Other studies also reported that there was no significant correlation between delusion of theft and cognitive functions (Kazui et al, 2006;Terada et al, 2005).…”

Section: Introductionmentioning

confidence: 96%

“…As for cognitive function, some studies reported that there was a significant correlation between delusion and scores on generalized cognitive psychological tests such as the Mini Mental State Examination (MMSE) (Folstein, Folstein, & McHugh, 1975;Haupt et al, 1996;Jeste et al, 1992;Takechi, Yamada, Sugihara, & Kita, 2006), whereas other studies reported that there was no significant correlation (Burns et al, 1990;Ikeda et al, 2003;Migliorelli et al, 1995). Only a few studies have examined the relation between delusion and particular neuropsychological cognitive functions.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors for delusion of theft in patients with Alzheimer's disease showing mild Dementia in Japan

Murayama

Iseki

Endo

et al. 2009

Aging & Mental Health

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The mechanism underlying delusion in Alzheimer's disease patients has not been fully clarified; however, the occurrence of delusion is a critical issue for dementia patients and their caregivers. In Japan, delusion of theft is the most frequent delusion in AD patients. We examined the risk factors for delusion of theft in AD patients showing mild dementia. Fifty-six AD patients were administered HDS-R, MMSE and COGNISTAT, including the 'speech sample', to assess their neuropsychological and social cognitive functions. The age, years of education, presence of cohabiting family members and premorbid personality traits were obtained from family members. About 25.0% of AD patients showed delusion of theft (D-group), and 75% did not (non-D-group). About 33.3% of female patients and 5.9% of male patients were included in the D-group (p < 0.05). About 13.6% of patients who were cohabiting with family members and 66.7% of patients who were living alone were included in the D-group (p < 0.05). About 35.1% of patients who had a neurotic personality and 5.3% of patients who did not were included in the D-group (p < 0.05). There were no significant differences in scores on HDS-R, MMSE and COGNISTAT sub-scales, except for 'speech sample', between the two groups. In the 'speech sample', 38.7% of patients who understood a relationship between two boys and 12.0% of patients who did not were included in the D-group (p < 0.05). These results indicated that delusion of theft in AD patients was related to female gender, absence of cohabiting family members, neurotic personality and retained social cognitive function.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Risk factors for delusion of theft in patients with Alzheimer's disease showing mild Dementia in Japan

Murayama

Iseki

Endo

et al. 2009

Aging & Mental Health

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“…While some previous studies on nursing caregivers for dementia patients have investigated elements such as care burden7, 8 ) , depression9, 10 ) and sleep11 ) , we were unable to locate any reports that had investigated whether the nursing caregiver consciously providing only minimal nursing care has a beneficial effect on the ADL/IADL independence of dementia patients.…”

Section: Introductionmentioning

confidence: 91%

Effects on activities of daily living and instrumental activities of daily living independence in patients with Alzheimer’s disease when the main nursing caregiver consciously provides only minimal nursing care

et al. 2019

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[Purpose] We investigated whether the activities of daily living and instrumental activities of daily living independence in patients with Alzheimer’s disease are positively affected by the main nursing caregiver consciously aiming to provide only minimal nursing care. [Participants and Methods] The participants comprised 105 patients (men: 46, women: 59, mean age: 80.1 ± 6.7 years). We conducted interviews to establish whether the main nursing caregivers consciously aimed to provide only minimal nursing care (care consciousness), and participants were thus divided into two groups. Hyogo Activities of Daily Living Scale scores of the groups with and without care consciousness were compared by dementia severity. [Results] In patients with mild Alzheimer’s disease, activities of daily living and instrumental activities of daily living independence in the group with care consciousness were significantly higher than in the group without care consciousness. In patients with moderate Alzheimer’s disease, instrumental activities of daily living independence was significantly higher in the group with care consciousness than in the group without care consciousness. [Conclusion] Thus, positive effects on the activities of daily living and instrumental activities of daily living independence are observed when the main nursing caregivers consciously aim to provide only minimal nursing care to patients with Alzheimer’s disease.

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“…While some authors found a significant association between BPSD and cognitive function [6,7] , for others, behavioral syndromes and cognitive impairment seemed to be relatively independent dimensions and should be examined individually for different prognostic significance [8][9][10] .…”

Section: Neuropsychiatric Symptomsmentioning

confidence: 99%

Neuropsychiatric Symptoms Underlying Caregiver Stress and Insight in Alzheimer’s Disease

Rocca

Leotta

Liffredo

et al. 2010

Dement Geriatr Cogn Disord

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Objective: Cluster analysis based on Alzheimer’s disease (AD) neuropsychiatric profile demonstrated validity on caregiver burden, nursing-home placement and survival. The aims of our study were to explore the validity of this approach on caregiver burden, lack of insight and cognitive impairment and to examine the impact of neuropsychiatric profiles on these variables. Method: A data-driven approach (two-step cluster analysis) identified groups of patients based on similarities of their neuropsychiatric symptom profile, as assessed by the Neuropsychiatric Inventory (NPI). ANOVAs and χ² tests were used to compare groups with regard to continuous and categorical variables. Linear regressions tested the relationships between NPI and clinical variables. Results: Psychotic/behavioral, depressive and minimally symptomatic clusters differed for caregiver burden and lack of insight. Patients in the minimally symptomatic cluster showed better insight than those in the depressive cluster. Caregivers of the psychotic/behavioral cluster experienced the highest burden. We found positive relationships between NPI and lack of insight in the depressive and minimally symptomatic clusters and between NPI and caregiver burden in all three clusters. Caregiver burden was influenced by the type of symptoms. Conclusions: The cluster analysis was valid for lack of insight and caregiver burden. Symptoms predominant on caregiver burden could become targets for therapy.

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Behavioral and psychological symptoms, cognitive impairment and caregiver burden related to Alzheimer's disease patients treated in an outpatient memory clinic

Abstract: These analyses will contribute to better assessment of AD patients and their caregivers, hopefully resulting in better support for them.

Cited by 7 publications

References 29 publications

Risk factors for delusion of theft in patients with Alzheimer's disease showing mild Dementia in Japan

Risk factors for delusion of theft in patients with Alzheimer's disease showing mild Dementia in Japan

Effects on activities of daily living and instrumental activities of daily living independence in patients with Alzheimer’s disease when the main nursing caregiver consciously provides only minimal nursing care

Neuropsychiatric Symptoms Underlying Caregiver Stress and Insight in Alzheimer’s Disease

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