Behavioral and stereological analysis of the prefrontal cortex of rats submitted to chronic alcohol intake

Conte, Rafael; Ladd, Fernando Vagner Lobo; Ladd, Aliny Antunes Barbosa Lobo; Moreira, Amanda Lopez; Sueur-Maluf, Luciana Le; Viana, Milena de Barros; Céspedes, Isabel Cristina

doi:10.1016/j.bbr.2019.01.003

Cited by 15 publications

(14 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The corresponding rodent areas are the cingulate (Cg), prelimbic (PL), and infralimbic (IL) cortices, respectively 97 . In rodents, the IL seems especially vulnerable to the neurotoxic effects of chronic alcohol intoxication, as shown by reduced expression of glutamatergic marker genes and a reduction in the total volume of neurons 80,98 .…”

Section: Substrates Of Decision Making In Alcohol Addictionmentioning

confidence: 99%

Developing neuroscience-based treatments for alcohol addiction: A matter of choice?

et al. 2019

View full text Add to dashboard Cite

Excessive alcohol use is the cause of an ongoing public health crisis, and accounts for ~5% of global disease burden. A minority of people with recreational alcohol use develop alcohol addiction (hereafter equated with “alcohol dependence” or simply “alcoholism”), a condition characterized by a systematically biased choice preference for alcohol at the expense of healthy rewards, and continued use despite adverse consequences (“compulsivity”). Alcoholism is arguably the most pressing area of unmet medical needs in psychiatry, with only a small fraction of patients receiving effective, evidence-based treatments. Medications currently approved for the treatment of alcoholism have small effect sizes, and their clinical uptake is negligible. No mechanistically new medications have been approved since 2004, and promising preclinical results have failed to translate into novel treatments. This has contributed to a reemerging debate whether and to what extent alcohol addiction represents a medical condition, or reflects maladaptive choices without an underlying brain pathology. Here, we review this landscape, and discuss the challenges, lessons learned, and opportunities to retool drug development in this important therapeutic area.

show abstract

Section: Substrates Of Decision Making In Alcohol Addictionmentioning

confidence: 99%

Developing neuroscience-based treatments for alcohol addiction: A matter of choice?

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The effects of alcohol can vary greatly in relation to the daily amount and type of consumed drink. To date, the adverse effects of alcohol consumption on various parts of the body are known including the cardiovascular system, immune system, liver, intestine, and nervous system [67][68][69][70][71][72][73]. In particular, alcohol is regarded as a negative CNS modulator, since it has been shown that prolonged alcohol consumption can induce neuronal death and impaired brain development [74].…”

Section: Chronic Consumption Of Alcohol and Oligodendrocytesmentioning

confidence: 99%

Environmental and Nutritional “Stressors” and Oligodendrocyte Dysfunction: Role of Mitochondrial and Endoplasmatic Reticulum Impairment

et al. 2020

View full text Add to dashboard Cite

Oligodendrocytes are myelinating cells of the central nervous system which are generated by progenitor oligodendrocytes as a result of maturation processes. The main function of mature oligodendrocytes is to produce myelin, a lipid-rich multi-lamellar membrane that wraps tightly around neuronal axons, insulating them and facilitating nerve conduction through saltatory propagation. The myelination process requires the consumption a large amount of energy and a high metabolic turnover. Mitochondria are essential organelles which regulate many cellular functions, including energy production through oxidative phosphorylation. Any mitochondrial dysfunction impacts cellular metabolism and negatively affects the health of the organism. If the functioning of the mitochondria is unbalanced, the myelination process is impaired. When myelination has finished, oligodendrocyte will have synthesized about 40% of the total lipids present in the brain. Since lipid synthesis occurs in the cellular endoplasmic reticulum, the dysfunction of this organelle can lead to partial or deficient myelination, triggering numerous neurodegenerative diseases. In this review, the induced malfunction of oligodendrocytes by harmful exogenous stimuli has been outlined. In particular, the effects of alcohol consumption and heavy metal intake are discussed. Furthermore, the response of the oligodendrocyte to excessive mitochondrial oxidative stress and to the altered regulation of the functioning of the endoplasmic reticulum will be explored.

show abstract

“…На різних етапах формування алкогольної залежності виявлені структурно-функціональні зміни в ключових структурах мозкової системи емоційного підкріплення: мигдалевидному комплексі, гіпокампі, гіпоталамусі, прилеглому ядрі [5][6][7]. Префронтальна кора головного мозку, яка в функціональній системі цілеспрямованої поведінки відповідає за прийняття рішення, також чутлива до дії алкоголю [8,9]. Відмова від вживання алкоголю призводить до деякої компенсації нейрорегуляторних та метаболічних порушень, але не впливає на потяг до приймання алкоголю та може призвести до рецидиву.…”

unclassified

“…Кореляційний аналіз взаємозв'язків біопотенціалів мозку на ЕЕГ неспання щурів з алкогольною залежністю виявив недостатню нейрональну взаємодію між Cort (структурою, яка в нормі конт ро лює емоційно-мотиваційну поведінку) та структурами лімбічного мозку, що узгоджується з даними Conte R. et al [8] (рис. 3).…”

unclassified

See 1 more Smart Citation

Peculiarities of neuroregulatory mechanisms of adaptation under alcohol dependence (experimental study)

Берченко¹,

Тіткова²,

Shlyakhova³

et al. 2021

UVP

View full text Add to dashboard Cite

Neurophysiological and biochemical markers of alcohol dependence were identified in a study conducted in laboratory rats at the systemic and molecular levels. It has been shown that long-term alcohol consumption is accompanied by an increase in dopamine levels in the ventral tegmental area and a decrease in GABA and BDNF levels in the hippocampus and serum and leads to attenuation of neocortex control of the limbic emotional-motivational system of the brain. Disturbance of the mechanisms of structural and functional organization of wake-sleep processes and regulation of emotional reactions, which is reflected in the suppression of slow-wave sleep, reduction of paradoxical sleep, inhibition of positive emotional centers, the development of anxiety and depression have been determined. Key words: alcohol dependence, sleep-wake, anxiety, depression, catecholamines, GABA, BDNF

show abstract

Behavioral and stereological analysis of the prefrontal cortex of rats submitted to chronic alcohol intake

Cited by 15 publications

References 47 publications

Developing neuroscience-based treatments for alcohol addiction: A matter of choice?

Developing neuroscience-based treatments for alcohol addiction: A matter of choice?

Environmental and Nutritional “Stressors” and Oligodendrocyte Dysfunction: Role of Mitochondrial and Endoplasmatic Reticulum Impairment

Peculiarities of neuroregulatory mechanisms of adaptation under alcohol dependence (experimental study)

Contact Info

Product

Resources

About