Behavioral effects of aluminum ingestion on animal and human subjects

Bowdler, Noelle C.; Beasley, Daniel S.; Fritze, Eugen; Goulette, A. M.; Hatton, J. D.; Hession, J.; Ostman, D. L.; Rugg, David; Schmittdiel, C. J.

doi:10.1016/0091-3057(79)90225-9

Cited by 94 publications

(32 citation statements)

References 14 publications

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“…Al accumulation in the brain was demonstrated to induce neuropathy, thereby resulting in the initial symptom of AD 23) . High Al serum levels in aged humans and Al-exposed experimental animal were found to be associated with deficient long-term memory 47,49) . In the present study, rats treated with Al (mal) 3 had significantly higher Al levels in brain tissue than those in the saline or maltolate groups.…”

Section: Discussionmentioning

confidence: 99%

Aluminium-Maltolate-induced Impairment of Learning, Memory and Hippocampal Long-term Potentiation in Rats

Liang

Wang

et al. 2012

Ind Health

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Recently, aluminium (Al) has been proposed to be one of the environmental factors responsible for cause Alzheimer's disease (AD). However, the relationship between Al and AD is controversial. To investigate the effects of subchronic Aluminium-maltolate (Al (mal) 3 ) exposure on the behavioral, electrophysiological functions. Forty Sprague-Dawley (SD) rats were randomly distributed into five groups. Over two months, rats in the saline group received daily intraperitoneal (i.p.) injections 0.9% saline, rats in the maltolate group received 7.56 mg/kg maltolate, and rats in the 0.27, 0.54, 1.08 mg/kg Al (mal) 3 groups received i.p. administrations of these three doses, respectively. Neural behavior was assessed in Morris water maze. Long-term potentiation (LTP) in hippocampus was recorded. Al content in the neocortex was determined using a graphite furnace atomic absorption spectrophotometer. Our studies indicate that subchronic Al (mal) 3 exposure significantly impaired spatial learning and memory abilities, suppressed the LTP in the CA1 hippocampal area, and elevated Al levels in cerebral cortex in a dose-dependent fashion. In conclusion, low doses of Al (mal) 3 can still lead to dramatic Al accumulation in the brain, severely impair learning and memory capacities, and hippocampal LTP.

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Section: Discussionmentioning

confidence: 99%

Aluminium-Maltolate-induced Impairment of Learning, Memory and Hippocampal Long-term Potentiation in Rats

Liang

Wang

et al. 2012

Ind Health

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“…An increased horizontal movement in an open field was reported in 60-day-old rats given Al chloride orally at varying doses (0-184.5 mg Al/kg/day) for 21-28 days [35], while no evidence for a deleterious effect of Al ingestion on cognitive behavior in 22-day-old rats subjected as weanlings to 60 days of oral administration of Al hydroxide [16] was found. Also, dietary Al exposure at 1,500, 2,500 and 3,500 mg/kg for 1 month failed to demonstrate Al exposure-related changes in mouse-killing behavior, open-field activity and latency to a passive conditioned avoidance response.…”

Section: Discussionmentioning

confidence: 99%

Behavioral Effects of Aluminum in Mice: Influence of Restraint Stress

Colomina¹,

Sánchez²,

Sánchez-Turet³

et al. 1999

Neuropsychobiology

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The influence of restraint stress on potential aluminum (Al)-induced behavioral changes was assessed in CD-1 mice. Three groups of adult mice were given 0, 300 and 600 mg Al/kg body weight per day in drinking water for 2 weeks. One-half of the animals in each group were concurrently subjected to restraint stress during 1 h per day throughout the study. After cessation of treatment, open-field activity, active avoidance learning, and motor resistance and coordination of the animals were evaluated. At the end of the behavioral testing period, mice were killed and Al concentrations were determined in a number of tissues. There were no remarkable effects of Al, restraint stress or their combined administration on either open-field activity or on the number of avoidances in an automatic reflex conditioner. However, a lower motor resistance and coordination in a rotarod were observed following exposure to Al at 600 mg/kg/day, restraint alone or concurrent administration of Al (300 and 600 mg/kg/day) plus restraint stress. The levels of Al in whole brain and cerebellum were significantly enhanced in mice exposed to Al plus restraint. Although the present results scarcely show Al-induced neurobehavioral effects, the influence of restraint stress on Al levels in whole brain and cerebellum can be the basis for further studies on the potential role of this element in certain neurological disorders.

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“…Thus, hemodialysis of patients with severe kidney disease has led to toxic levels of Al in the blood, from exposure to aluminum in dialysis fluid and from the administration of high levels of aluminum-containing phosphate binders among patients who cannot excrete it. The resulting aluminum-induced dialysis encephalopathy following hemodialysis is accompanied by elevated levels of Al in the brain (Russo et al, 1992) and ingestion of Al salts can lead to the deposition of insoluble Al-containing materials within the brain (Bowdler et al, 1979). Clinical status is improved by therapeutic use of an Al chelator, desferrioxamine (Erasmus et al, 1995).…”

Section: Transitory Exposure To High Levels Of Aluminum Can Results Inmentioning

confidence: 99%

“…These include reports of in-coordination (Bowdler et al, 1979), changes in reactivity and neuropathological changes reminiscent of those found with brain aging (Miu et al, 2004).…”

Section: Experimental Results From Animals Support a Causal Relation mentioning

confidence: 99%

Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer's disease and age-related neurodegeneration

Bondy

2016

NeuroToxicology

208

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Behavioral effects of aluminum ingestion on animal and human subjects

Cited by 94 publications

References 14 publications

Aluminium-Maltolate-induced Impairment of Learning, Memory and Hippocampal Long-term Potentiation in Rats

Aluminium-Maltolate-induced Impairment of Learning, Memory and Hippocampal Long-term Potentiation in Rats

Behavioral Effects of Aluminum in Mice: Influence of Restraint Stress

Low levels of aluminum can lead to behavioral and morphological changes associated with Alzheimer's disease and age-related neurodegeneration

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