Behavioral effects of early life maternal trauma witness in rats

Liu, Hesong; Patki, Gaurav; Salvi, Ankita; Kelly, Matthew; Salim, Samina

doi:10.1016/j.pnpbp.2017.10.013

Cited by 11 publications

(6 citation statements)

References 28 publications

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“…The males appeared less anxious when exploring non-protected zones than the females, representing an unusual and non-adaptative characteristic for rodents. Such an uncommon behavior represents a symptomatic trait in neurological disorders, which could be reversed by female hormonal control as already described in other topics [31,32]. These results attest that male and female neuronal circuitries maturate according to different time sequences and molecular pathways, and that the impact of methyl donor deficiency could lead to delayed functional consequences [30].…”

Section: Discussionsupporting

confidence: 63%

Brain Susceptibility to Methyl Donor Deficiency: From Fetal Programming to Aging Outcome in Rats

Hassan

Coelho

Kökten

et al. 2019

IJMS

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Deficiencies in methyl donors, folate, and vitamin B12 are known to lead to brain function defects. Fetal development is the most studied but data are also available for such an impact in elderly rats. To compare the functional consequences of nutritional deficiency in young versus adult rats, we monitored behavioral outcomes of cerebellum and hippocampus circuits in the offspring of deficient mother rats and in adult rats fed a deficient diet from 2 to 8 months-of-age. We present data showing that the main deleterious consequences are found in young ages compared to adult ones, in terms of movement coordination and learning abilities. Moreover, we obtained sex and age differences in the deleterious effects on these functions and on neuronal layer integrity in growing young rats, while deficient adults presented only slight functional alterations without tissue damage. Actually, the cerebellum and the hippocampus develop and maturate according to different time lap windows and we demonstrate that a switch to a normal diet can only rescue circuits that present a long permissive window of time, such as the cerebellum, whereas the hippocampus does not. Thus, we argue, as others have, for supplements or fortifications given over a longer time than the developmental period.

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Section: Discussionsupporting

confidence: 63%

Brain Susceptibility to Methyl Donor Deficiency: From Fetal Programming to Aging Outcome in Rats

Hassan

Coelho

Kökten

et al. 2019

IJMS

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“…These findings were consistent with a study from Hesong Liu, Gaurav Patki et al, which found that experiencing early-life maternal stress causes depression-like behavior later in adulthood for PND 60. This research was found in male and female rats, implying no gender difference in this behavior (58). A difference was found in depression in female rats; differences in experimental design, control group, strain differences, or a combination of these factors might cause such discrepancies, these may also explain the high standard deviation of male rats in the blank control group and the PTSD group.…”

Section: Discussionmentioning

confidence: 64%

Long-Lasting Sex-Specific Effects Based On Emotion- and Cognition-Related Behavioral Assessment of Adult Rats After Post-Traumatic Stress Disorder From Different Lengths of Maternal Separation

Yang

Sun

et al. 2019

Front. Psychiatry

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Adverse early life stress is a major cause of vulnerability to various mental disorders in adulthood, including post-traumatic stress disorder (PTSD). Recent studies have suggested that early life stress can help the body adapt optimally when faced with stressful trauma in adult life. An interaction may exist between early life stress (e.g., childhood trauma) and vulnerability to PTSD. This study aimed to evaluate emotion-related behaviors and verify the long-lasting effects of cognitive aspects of PTSD after exposure to severe adverse early life stress, such as long-term separation. Adverse early life stress was simulated by subjecting rats to 3 or 6 consecutive hours of maternal separation (MS) daily, from postnatal day (PND) 2 to PND 14. Single-prolonged stress (SPS) was simulated on PND 80 to imitate other adulthood stresses of PTSD with gender divisions (M-MS3h-PTSD, F-MS3h-PTSD, M-MS6h-PTSD, F-MS6h-PTSD, M-PTSD, and F-PTSD). After the MS and PTSD sessions, behavioral tests were conducted to assess the effectiveness of these treatments, which included an open field test (OFT), elevated plus maze test (EPMT), water maze test (WMT), and forced swimming test (FST) to detect anxiety-like behavior (OFT and EPMT), memory behavior (WMT), and depressive behavior (FST). The M-MS3h-PTSD group had fewer time entries into the open arms of EPMT than the F-MS3h-PTSD group, and the M-MS6h-PTSD group demonstrated fewer up-right postures in the OFT than the F-MS6h-PTSD group. The M-MS3h-PTSD group exhibited more exploratory behavior than the M-MS6h-PTSD and M-PTSD groups in the OFT. Less exploratory behavior was observed in the F-MS3h-PTSD group than in the F-MS6h-PTSD group, which demonstrated significantly increased freezing times in the FST compared to the F-PTSD group. The WMT revealed significant differences in learning and memory performance between the M-MS3h-PTSD group and other treatment groups, which were not found in the female rats. These findings demonstrate that an early stressful experience, such as MS, may be involved in helping the body adapt optimally when faced with additional trauma in adulthood, although mild early life stress might benefit learning and memory among males.

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“…A review by Perez-Cerezales and colleagues [ 106 ] nicely summarizes human and animal studies examining sex-specific responses to environmental stressors during both the periconception period (caused by differences in sex chromosome dosage) and placental development (caused by both sex chromosomes and hormones). In terms of postnatal early stress, Liu and colleagues [ 45 ] showed that witnessing maternal trauma between PD 21 and PD 27 (dam of offspring was exposed to an aggressive male rat 3 times a day for 7 consecutive days, while the offspring PD 21–27 was placed within proximity) induced behavioral despair phenotype in forced-swim test at PD 60 in both male and female offspring rats, with greater effects in male rats. Forced-swim test, as introduced by Porsolt and colleagues [ 107 ], measures behavioral despair, a “depressive-like” phenotype in rodents that is sensitive to a wide range of antidepressant drugs.…”

Section: Early Life Stress Modelsmentioning

confidence: 99%

On the Developmental Timing of Stress: Delineating Sex-Specific Effects of Stress across Development on Adult Behavior

Schroeder

Notaras

et al. 2018

Brain Sciences

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Stress, and the chronic overactivation of major stress hormones, is associated with several neuropsychiatric disorders. However, clinical literature on the exact role of stress either as a causative, triggering, or modulatory factor to mental illness remains unclear. We suggest that the impact of stress on the brain and behavior is heavily dependent on the developmental timing at which the stress has occurred, and as such, this may contribute to the overall variability reported on the association of stress and mental illness. Here, animal models provide a way to comprehensively assess the temporal impact of stress on behavior in a controlled manner. This review particularly focuses on the long-term impact of stress on behavior in various rodent stress models at three major developmental time points: early life, adolescence, and adulthood. We characterize the various stressor paradigms into physical, social, and pharmacological, and discuss commonalities and differences observed across these various stress-inducing methods. In addition, we discuss here how sex can influence the impact of stress at various developmental time points. We conclude here that early postnatal life and adolescence represent particular periods of vulnerability, but that stress exposure during early life can sometimes lead to resilience, particularly to fear-potentiated memories. In the adult brain, while shorter periods of stress tended to enhance spatial memory, longer periods caused impairments. Overall, males tended to be more vulnerable to the long-term effects of early life and adolescent stress, albeit very few studies incorporate both sexes, and further well-powered sex comparisons are needed.

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Behavioral effects of early life maternal trauma witness in rats

Abstract: Our findings suggest that early life maternal stress witness history leads to depression-like behavior in both male and female adult rats, and dams developed both anxiety and depression-like behaviors.

Cited by 11 publications

References 28 publications

Brain Susceptibility to Methyl Donor Deficiency: From Fetal Programming to Aging Outcome in Rats

Brain Susceptibility to Methyl Donor Deficiency: From Fetal Programming to Aging Outcome in Rats

Long-Lasting Sex-Specific Effects Based On Emotion- and Cognition-Related Behavioral Assessment of Adult Rats After Post-Traumatic Stress Disorder From Different Lengths of Maternal Separation

On the Developmental Timing of Stress: Delineating Sex-Specific Effects of Stress across Development on Adult Behavior

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