Behavioral effects of long‐term oral administration of aluminum ammonium sulfate in male and female C57<scp>BL</scp>/6J mice

Shoji, Hirotaka; Irino, Yasuhiro; Yoshida, Masaru; Miyakawa, Tsuyoshi

doi:10.1002/npr2.12002

Cited by 9 publications

(9 citation statements)

References 79 publications

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“…Most literature data about the low dose Al toxicity is based on the experiments where Al is administered orally. Direct evidence of neurotoxicity due to low doses of Al is controversial, e.g., Shoji et al reported that 0.97-9.7 mg/kg/day Al per os for 60 days did not induce statistically significant behavioral changes in C57BL/6J mice [35], whereas Martinez et al found that 8.3 mg/kg/day Al per os for 60 days promoted the development of mechanical allodynia, catalepsy, increased inflammation in the sciatic nerve, and systemic oxidative stress, and was able to be retained in the sciatic nerve [36].…”

Section: Discussionmentioning

confidence: 99%

Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress

et al. 2020

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Aluminum accumulation, glutathione (GSH) and malondialdehyde (MDA) concentrations as well as catalase (CAT) and superoxide dismutase (SOD) activities were determined in erythrocytes and brain and liver homogenates of BALB/c mice treated with Al 3+ (7.5 mg/kg/day (0.15 LD 50 ) as AlCl 3 (37.08 mg/kg/day), whereas HCl (30.41 mg/kg/day) was used as Cl − control, the treatments were performed for 21 days, i.p., in the presence and absence of rosmarinic acid (0.2805 mg/kg/day (0.05 LD 50 ), 21 days, i.g.) or carvacrol (0.0405 mg/kg/day (0.05 LD 50 ), 21 days, i.g.). The treatment with AlCl 3 increased GSH concentration in erythrocytes only slightly and had no effect on brain and liver homogenates. Rosmarinic acid and carvacrol strongly increased GSH concentration in erythrocytes but decreased it in brain and liver homogenates. However, AlCl 3 treatment led to Al accumulation in mice blood, brain, and liver and induced oxidative stress, assessed based on MDA concentration in the brain and liver. Both rosmarinic acid and carvacrol were able to counteract the negative Al effect by decreasing its accumulation and protecting tissues from lipid peroxidation. AlCl 3 treatment increased CAT activity in mice brain and liver homogenates, whereas the administration of either rosmarinic acid or carvacrol alone or in combination with AlCl 3 had no significant effect on CAT activity. SOD activity remained unchanged after all the treatments in our study. We propose that natural herbal phenolic compounds rosmarinic acid and carvacrol could be used to protect brain and liver against aluminum induced oxidative stress leading to lipid peroxidation.

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Section: Discussionmentioning

confidence: 99%

Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress

et al. 2020

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“…At least 30 minutes before the beginning of each test, the mice were transferred to sound‐attenuated rooms adjacent to the housing room and acclimated to the room set up for each test (see Refs ). The mice were tested in the following order: general health and neurological screen, light/dark transition, open field, elevated plus maze, hot plate, social interaction, rotarod, three‐chamber social approach, ASR/PPI, Porsolt forced swim, T‐maze spontaneous alternation, Barnes maze, tail suspension, contextual and cued fear‐conditioning tests, as previously described . Behavioral testing was performed between 9:00 am and 6:00 pm .…”

Section: Methodsmentioning

confidence: 99%

“…The mice were tested in the following order: general health and neurological screen, light/dark transition, open field, elevated plus maze, hot plate, social interaction, rotarod, three-chamber social approach, ASR/PPI, Porsolt forced swim, T-maze spontaneous alternation, Barnes maze, tail suspension, contextual and cued fear-conditioning tests, as previously described. 27 Behavioral testing was performed between 9:00 AM and 6:00 PM.…”

Section: Behavioral Test Batterymentioning

confidence: 99%

Age‐related behavioral changes from young to old age in male mice of a C57BL/6J strain maintained under a genetic stability program

Shoji

Miyakawa

2019

Neuropsychopharm Rep

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149

103

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Aim Aging is thought to coincide with gradual and progressive changes in brain function and behavior over the lifetime. Our previous meta‐analytic study reported age‐related behavioral changes from young to middle age in male C57BL/6J mice. However, the previous study had some limitations that could affect the generalizability of the findings because of the potential influence of genetic and environmental factors on behavior, in addition to a lack of information regarding the behaviors of old‐aged mice. Here, to investigate age‐related behavioral changes from young to old age in mice, we analyzed the behaviors of male C57BL/6J mice from four different age groups (8, 47, 73, and 99 weeks of age at the beginning of the experiment) from a colony that had been maintained in a genetically controlled condition based on The Jackson Laboratory's Genetic Stability Program in an environmentally controlled animal facility. Methods We used a battery of behavioral tests, including the light/dark transition, open field, elevated plus maze, hot plate, social interaction, rotarod, three‐chamber social approach, prepulse inhibition, Porsolt forced swim, T‐maze, Barnes maze, tail suspension, and fear‐conditioning tests. Results Some behavioral changes occurred between young and middle age, and further changes in various behaviors were observed in old age. Decreased locomotor activity and increased anxiety‐like behavior were found in old‐aged mice compared to those in young and middle‐aged mice in the light/dark transition test. Similarly, an age‐dependent decrease in locomotor activity was observed in the open field test and the elevated plus maze test, while there was an age‐dependent increase in the time spent in the center area in the open field test and there were no significant differences among age groups in behavioral measures of anxiety in the elevated plus maze test. Decreases in motor performance and the auditory startle response were found in middle‐aged mice compared to those in young mice. Similar behavioral changes and increased pain sensitivity, decreased social novelty preference, reduced working and spatial memory, and impaired cued fear memory were observed in old‐aged mice compared to those in young mice. Prepulse inhibition was higher in middle‐aged mice than in young and old‐aged mice. Age‐related changes in depression‐related behavior were dependent on the type of test and the test time period. Conclusions This study generally confirmed our previous report regarding age‐related behavioral changes from young to middle age and expanded the previous observations by examining the behaviors of old‐aged mice. Our results show age‐related changes in a wide range of behaviors in mice from young to old age. Most behaviors showed gradual changes with advancing age, but some types of behaviors, such as vertical activity, prepulse inhibition, and depression‐related behavior, did not show unidirectional changes with age. These findings provide basic information about the behavioral characteristics of young, middl...

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“…The percentage of alternation was calculated as (alternation/maximum alternation) × 100. Data acquisition and analysis were performed automatically using the ImageYM program …”

Section: Methodsmentioning

confidence: 99%

“…Behavioral data were obtained automatically by applications (ImageLD, ImageEP, ImageSI, ImageCSI, ImagePS, ImageYM, and ImageFZ) based on the public domain NIH Image program and ImageJ program, and modified for each test.…”

Section: Methodsmentioning

confidence: 99%

Effects of chronic fentanyl administration on behavioral characteristics of mice

Fujii

Koshidaka

Adachi

et al. 2018

Neuropsychopharm Rep

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Background Fentanyl, a synthetic opioid categorized as a narcotic analgesic, has a 100‐ to 200‐fold stronger effect than most opioids, such as morphine. Fatal accidents due to chronic use and abuse of fentanyl are a worldwide social problem. One reason for the abuse of fentanyl is its psychostimulant effects that could induce behavioral changes. The effects of chronic fentanyl administration on behavior, however, are unclear. Methods Adult male C57BL/6J mice were chronically administered fentanyl (0.03 or 0.3 mg/kg/d i.p.), and various behaviors were assessed using a behavioral test battery. Results Mice chronically administered a high dose of fentanyl (0.3 mg/kg/d) exhibited decreased anxiety‐like behavior as assessed by the open field and elevated plus maze tests. On the other hand, interruption of fentanyl administration led to increased anxiety‐like behavior as observed in the light and dark transition test. The hot plate test revealed that chronic administration of fentanyl reduced pain sensitivity. High‐dose chronic fentanyl administration reduced the locomotor stimulatory effects of cocaine. The results, however, failed to reach the threshold for study‐wide statistical significance. Conclusion Chronic fentanyl administration induces some behavioral changes in mice. Although further studies are needed to clarify the underlying mechanisms of the behavioral effects of chronic fentanyl administration, our findings suggest that fentanyl is safe under properly controlled conditions.

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Behavioral effects of long‐term oral administration of aluminum ammonium sulfate in male and female C57BL/6J mice

Abstract: Background: Aluminum (Al) is considered to be a neurotoxic metal, and excessive

Cited by 9 publications

References 79 publications

Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress

Natural Compounds Rosmarinic Acid and Carvacrol Counteract Aluminium-Induced Oxidative Stress

Age‐related behavioral changes from young to old age in male mice of a C57BL/6J strain maintained under a genetic stability program

Effects of chronic fentanyl administration on behavioral characteristics of mice

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