Behavioral effects of triadimefon in zebrafish are associated with alterations of the dopaminergic and serotonergic pathways

Paredes-Zúñiga, Susana; Trost, Nils; Paz, Javiera F. De la; Alcayaga, Julio; Allende, Miguel L.

doi:10.1016/j.pnpbp.2018.12.012

Cited by 28 publications

(18 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Triadimefon (TDF, [4-chlorophenoxy]-3, 3-dimethyl-1-[1H-1, 2, 4-triazol-1-yl] butan-2one); (Paredes-Zuniga, Trost, De la Paz, Alcayaga, & Allende, 2019), is an efficient triazole fungicide (Reeves, Thiruchelvam, Richfield, & Cory-Slechta, 2004) that is used in the prevention and control of rust and powdery mildew in wheat, vegetables, fruit trees, and tobacco (Crowell, Henderson, Kenneke, & Fisher, 2011;Jie & Mei, 2015). In plants and fungi, TDF can be converted into triadimenol (TDN)(Z.…”

Section: Introductionmentioning

confidence: 99%

A colloidal gold immunochromatography test strip based on a monoclonal antibody for the rapid detection of triadimefon and triadimenol in foods

Lü

Song

et al. 2020

Food and Agricultural Immunology

View full text Add to dashboard Cite

In this study, we produced a specific monoclonal antibody (mAb) against triadimefon (TDF) and triadimenol (TDN). The half-maximal inhibitory concentration for TDF and TDN was 5.25 and 9.98 ng/ mL, respectively, with a linear detection range (IC 20-IC 80) of 1.09-25.35 and 2.29-43.61 ng/mL, respectively. Subsequently, we developed a colloidal gold immunochromatography test strip for the analysis of TDF and TDN in tomato. The results obtained from the colloidal gold immunochromatography test strip were in accordance with those obtained from the indirect competitive enzyme-linked immunosorbent assay. The colloidal gold immunochromatography test strip is efficient and suitable for onsite detection of TDF and TDN.

show abstract

Section: Introductionmentioning

confidence: 99%

A colloidal gold immunochromatography test strip based on a monoclonal antibody for the rapid detection of triadimefon and triadimenol in foods

Lü

Song

et al. 2020

Food and Agricultural Immunology

View full text Add to dashboard Cite

show abstract

“…Neurotoxic syndrome in rats, is characterized by increasing motor activity [82,83] can be related to aggressiveness when adult zebra sh were exposed to 5 mg/L triadimefon. This result suggests that triadimefon could also cause neurotoxicity in aquatic ecosystems [18]. The least concentration altered neither locomotor activity nor concentrations of dopamine, but caused changes in expressions of two genes, tyrosine hydroxylase 1 (th1) and dopamine transporter (dat).…”

Section: Neurotoxicity Hepatotoxicity and Cardiovascular Toxicitymentioning

confidence: 94%

“…Triadimefon also reduced extracellular serotonin and had an anxiolytic-like effect, accompanied by lesser production of cortisol. Greater concentrations of triadimefon resulted in a dose-dependent reduction in locomotion, which was reversed or enhanced by SCH-23390 (D1) or Haloperidol (D2) dopamine receptor antagonists, respectively [18].…”

Section: Neurotoxicity Hepatotoxicity and Cardiovascular Toxicitymentioning

confidence: 99%

“…Regardless, its potential toxic potencies cannot be ignored. Results of several studies have demonstrated that triadimefon affected development [12,14,15], reproduction [16,17] of organisms and caused neurotoxicity [18], hepatotoxicity [19], cardiovascular toxicity [20] and oxidative stress [11,13]. In addition, triadimefon resulted in malformations of branchial arches in developing amphibians [21] and zebra sh (Danio rerio) or adversely affected development of embryos of mammals [22].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Triadimefon in Aquatic Environments: Occurrence, Fate, Toxicity and Risk

Hou

Jin

Liu

et al. 2021

Preprint

View full text Add to dashboard Cite

Background：As a triazole fungicide, triadimefon is widely used around the world. The ubiquitous occurrence of triadimefon in aquatic environments and potential adverse effects on aquatic organisms have resulted in global concerns. In this review, the current state of knowledge on occurrence, environmental behavior, and toxic effects are presented and used to conduct an assessment of risks posed by current concentrations of triadimefon in aquatic environments. Results: The key findings from this review are that: (1) triadimefon occurred widely in surface waters, with high rates of detection; (2) abiotic degradation of triadimefon was affected by many factors. Stereo-selectivity was found during biotic degradation and metabolism of triadimefon. Different enantiomers can cause various adverse effects, which complicates the assessment and requires enantiomers-specific considerations; (3) triadimefon exposure can affect organisms by causing multiple toxic effects on the thyroid, reproduction system, liver, nervous system as well as carcinogenicity and teratogenicity, and it can also act synergistically with other pesticides. Long-term, low-dose effects were considered to be the main characteristics of toxic effects of triadimefon; (4) results of the risk assessment based on probabilistic relationships represented by Joint Probability Curves (JPCs) indicated that risk of triadimefon was classified as low risk.Conclusion: The concentration data of triadimefon in surface water is relatively less, more work needed to do to detect it. Reproductive toxicity was observed which indicated that triadimefon might result in adverse effects on the population level or even on the ecosystem level. Risk assessments for pesticides that cause long-term and low-dose effects on aquatic organisms such as triadimefon need to consider higher ecology level risk.

show abstract

“…Triadimefon (TDF,2, butan-2one); (Paredes-Zuniga, Trost, De la Paz, Alcayaga, & Allende, 2019), is an efficient triazole fungicide (Reeves, Thiruchelvam, Richfield, & Cory-Slechta, 2004) that is used in the prevention and control of rust and powdery mildew in wheat, vegetables, fruit trees, and tobacco (Crowell, Henderson, Kenneke, & Fisher, 2011;Jie & Mei, 2015). In plants and fungi, TDF can be converted into triadimenol (TDN) (Kong, Li, Chen, Bao, Fan, & Francis 2016), which possesses comparatively higher fungicidal activity.…”

Section: Introductionmentioning

confidence: 99%

A colloidal gold immunochromatography test strip based on a monoclonal antibody for the rapid detection of triadimefon and triadimenol in foods

Lü

Song

et al. 2020

Food and Agricultural Immunology

View full text Add to dashboard Cite

In this study, we produced a specific monoclonal antibody (mAb) against triadimefon (TDF) and triadimenol (TDN). The half-maximal inhibitory concentration for TDF and TDN was 5.25 and 9.98 ng/ mL, respectively, with a linear detection range (IC 20 -IC 80 ) of 1.09-25.35 ng/mL and 2.29-43.61 ng/mL, respectively. Subsequently, we developed a colloidal gold immunochromatography test strip for the analysis of TDF and TDN in tomato. The results obtained from the colloidal gold immunochromatography test strip were in accordance with those obtained from the indirect competitive enzyme-linked immunosorbent assay. The colloidal gold immunochromatography test strip is efficient and suitable for onsite detection of TDF and TDN.

show abstract

Behavioral effects of triadimefon in zebrafish are associated with alterations of the dopaminergic and serotonergic pathways

Cited by 28 publications

References 36 publications

A colloidal gold immunochromatography test strip based on a monoclonal antibody for the rapid detection of triadimefon and triadimenol in foods

A colloidal gold immunochromatography test strip based on a monoclonal antibody for the rapid detection of triadimefon and triadimenol in foods

Triadimefon in Aquatic Environments: Occurrence, Fate, Toxicity and Risk

A colloidal gold immunochromatography test strip based on a monoclonal antibody for the rapid detection of triadimefon and triadimenol in foods

Contact Info

Product

Resources

About