Behavioral Studies of Hearing Development

Werner, Lynne A.; Gray, Lincoln

doi:10.1007/978-1-4612-2186-9_2

Cited by 33 publications

(31 citation statements)

References 394 publications

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“…Innervation of the receptor hair cells by the spiral ganglion is near completion by the time that the neurons were removed for tissue culture (Sher, 1971;Rubel, 1978;Pujol et al, 1998). However, despite that newborn mice are responsive to sound within the first 2 weeks postnatally, they do not achieve adult sensitivity until 2 months after birth (Werner and Gray, 1998). Moreover, it has been shown that maturation progresses at different rates along the length of the cochlea, with the basal region attaining adult characteristics earlier than the apex (Rubel, 1978;Romand, 1983).…”

Section: Discussionmentioning

confidence: 98%

Firing features and potassium channel content of murine spiral ganglion neurons vary with cochlear location

Adamson

Reid

Mo³

et al. 2002

J of Comparative Neurology

167

210

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Neurons from varied regions of the central nervous system can show widely divergent responses to electrical stimuli that are determined by cell-specific differences in ion channel composition. The well-ordered and highly characterized peripheral auditory system allows one to explore the significance of this diversity during the final stages of postnatal development. We examined the electrophysiological features of murine spiral ganglion neurons in vitro at a time when recordings could be made from the cell bodies before myelination. These cells carry information about sound stimuli from hair cell receptors in the basilar membrane and are arranged tonotopically. Spiral ganglion neuron responses to depolarizing current injection were assessed with whole-cell current clamp recordings from cells that were isolated separately from the apical and basal thirds of the mouse cochlea. These cells displayed systematic variation in their firing. Apex neurons (low frequency coding) showed longer latency, slowly adapting responses, whereas base neurons (high frequency coding) showed short latency, rapidly adapting responses to the same stimuli. This physiological diversity was mirrored by regional differences in ion channel content assessed immunohistochemically. Apex neurons had a preponderance of Kv4.2 subunits, whereas base neurons possessed greater levels of K(Ca), Kv1.1, and Kv3.1 subunits. Taken together, these results indicate that the distribution of a set of voltage-gated potassium channels may relate specifically to a particular range of coding frequencies. These studies also suggest that intrinsic properties of spiral ganglion neurons can contribute to the characteristic responses of the peripheral auditory system. Their potential role in development and adult function is discussed.

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Section: Discussionmentioning

confidence: 98%

Firing features and potassium channel content of murine spiral ganglion neurons vary with cochlear location

Adamson

Reid

Mo³

et al. 2002

J of Comparative Neurology

167

210

View full text Add to dashboard Cite

show abstract

“…Further and closer examination of localization between pore-forming and ancillary subunits will provide insights to the functional outcome of their interactions. Although newborn mice are responsive to sound within the first 2 weeks after birth, they do not yet achieve full auditory maturity until adulthood at 2 months old (48). Maturation of the tonotopic map in the cochlea is not uniform; it progresses at different rates along the cochlear axis, starting with the basal and then the apical region (49).…”

Section: Discussionmentioning

confidence: 99%

Functional Significance of K+ Channel β-Subunit KCNE3 in Auditory Neurons

Wang

Kim

Lee

et al. 2014

Journal of Biological Chemistry

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“…Perceptual deficits of the size observed in adults could have a large effect on the acquisition of complex skills in childhood, when the central nervous system is immature. Although some auditory functions, such as filter bandwidth, mature in the 1st year of life, others, such as frequency discrimination, do not develop fully until the early school years (see Werner & Gray, 1998). Massaro and Burke (1991) reported another example of delayed maturation.…”

Section: Notesmentioning

confidence: 99%

Auditory frequency discrimination in adult developmental dyslexics

Rosner

Hansen

Calvin

et al. 2002

Perception & Psychophysics

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Developmental dyslexics reportedly discriminate auditory frequency poorly. A recent study found no such deficit. Unlike its predecessors, however, it employed multiple exposures per trial to the standard stimulus. To investigate whether this affects frequency discrimination in dyslexics, a traditional twointerval same-different paradigm (2I_1A_X) and a variant with six A-stimuli per trial (2I_6A_X) were used here. Frequency varied around 500 Hz; interstimulus interval (ISI) ranged between 0 and 1,000 msec. Under 2I_1A_X, dyslexics always had larger just noticeable differences (JNDs) than did controls. Dyslexic and control JNDs were equal at shorter ISIs under 2I_6A_X, but dyslexics became worse than controls at longer ISIs. Signal detection analysis suggests that both sensory variance and trace variance are larger in dyslexics than in controls.

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Behavioral Studies of Hearing Development

Cited by 33 publications

References 394 publications

Firing features and potassium channel content of murine spiral ganglion neurons vary with cochlear location

Firing features and potassium channel content of murine spiral ganglion neurons vary with cochlear location

Functional Significance of K+ Channel β-Subunit KCNE3 in Auditory Neurons

Auditory frequency discrimination in adult developmental dyslexics

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